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Gene · 2555

GABRA2: gamma-aminobutyric acid type A receptor subunit alpha2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRA2: gamma-aminobutyric acid type A receptor subunit alpha2. Genes, record 2555. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2555

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Gene

Symbol
GABRA2
HGNC
Name
gamma-aminobutyric acid type A receptor subunit alpha2
HGNC
NCBI Gene ID
2555
NCBI Gene
HGNC ID
HGNC:4076
HGNC
Ensembl
ENSG00000151834
NCBI Gene
Aliases
DEE78, EIEE78
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P47869Gamma-aminobutyric acid receptor subunit alpha-24518Ensembl, GeneID, HGNC

Source UniProt

Patents85

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447226P47869Espacenet
JP 2026004568 A2026-01-1447227P47869Espacenet
JP 2026004568 A2026-01-1447231P47869Espacenet
JP 2026004568 A2026-01-1447232P47869Espacenet
EP 4650780 A22025-11-197304P47869Espacenet
EP 4641201 A22025-10-297257P47869Espacenet
JP 2025147176 A2025-10-065675P47869Espacenet
JP 2025147176 A2025-10-065676P47869Espacenet
JP 2025147176 A2025-10-065678P47869Espacenet
JP 2025147176 A2025-10-065680P47869Espacenet

1 to 10 of 85

See all 85 patents

Drugs80

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
AZD6280CHEMBL1783256GABA receptor alpha-2 subunit positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
AZD7325CHEMBL1783282GABA receptor alpha-2 subunit positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BROMAZEPAMCHEMBL277062GABA receptor alpha-2 subunit positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 80

See all 80 drugs

Trials1,181

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,409

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRA2 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).692025
ZIAAA000301Integrative genetics of behavior with high throughput technologies142025
P50AA012870Center for the Translational Neuroscience of Alcoholism92025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors82025
P60AA007611Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol82025
T32AA007477Multidisciplinary Alcoholism Research Training Program72025
R28AA012725Brain Tissue Resource Center for Alcohol Research62025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology42025
R01AA012404Gene Expression in the Human Alcoholic Brain42025
T32AA007459Alcohol Intervention Treatment Outcome Research Training42025

1 to 10 of 1,409Source NIH's project files

See all 1,409 nih grants

Papers1,001

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Cross-Matrix Peripheral Transcriptional Signature in Suicide Attempt: NR3C2 Downregulation in Blood and Buccal Swab Samples.Int J Mol Sci202642653190PubTator, text miningPubMed
Epigenetic Regulation of Modulatory Neurotransmitter System Integrity in the Aging Brain: A Scoping Review Across the Lifespan.Life (Basel)202642514192PubTator, text miningPubMed
Exploratory Analysis of Genetic Variants in BDNF, GABA Receptors, and Dopaminergic Pathways with Alcohol Use Disorder in a Spanish Cohort.Int J Mol Sci202642353097PubTator, text miningPubMed
Integration of network toxicology, WGCNA, and explainable machine learning to decipher the toxic molecular basis underlying DEGDB plasticizer-induced clear cell renal cell carcinoma (ccRCC) progression.
Comput Biol Chem202642224996PubTator, text miningPubMed
Neuroimmunological Mechanisms of Xiao-Yao-San Against Chronic Stress-Induced Colorectal Cancer: A Bioinformatics and Single-Cell Sequencing Study.Cancer Manag Res202641798904PubTator, text miningPubMed
Targeting molecular pathways in neuropathic cancer pain: from mechanisms to novel therapeutics.iScience202641782818PubTator, text miningPubMed
The potential of event-related beta oscillations as biomarkers for neuromodulatory treatment efficacy.Front Psychol202641756488PubTator, text miningPubMed
Integrated Transcriptomic and Histological Analysis of TP53/CTNNB1 Mutations and Microvascular Invasion in Hepatocellular Carcinoma.Genes (Basel)202641751574PubTator, text miningPubMed
Genomic insights into substance use and disinhibitory disorders.medRxiv202641728329PubTator, text miningPubMed
Case Report: A female case of X-linked intellectual disability syndrome type 34 caused by a NONO frameshift variant and literature review.Front Pediatr202641727761PubTator, text miningPubMed

1 to 10 of 1,001

See all 1,001 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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