Gene · 2555
GABRA2: gamma-aminobutyric acid type A receptor subunit alpha2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABRA2: gamma-aminobutyric acid type A receptor subunit alpha2. Genes, record 2555. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2555
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | 451 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents85
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47226 | P47869 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47227 | P47869 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47231 | P47869 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47232 | P47869 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7304 | P47869 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7257 | P47869 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5675 | P47869 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5676 | P47869 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5678 | P47869 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5680 | P47869 | Espacenet |
1 to 10 of 85
See all 85 patentsDrugs80
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABP-700 | CHEMBL4297255 | GABA-A receptor; anion channel agonist | AGONIST | ChEMBL |
| ACAMPROSATE | CHEMBL1201293 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ADIPIPLON | CHEMBL2103791 | GABA-A receptor; anion channel partial agonist | PARTIAL AGONIST | ChEMBL |
| ALPRAZOLAM | CHEMBL661 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| AZD6280 | CHEMBL1783256 | GABA receptor alpha-2 subunit positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| AZD7325 | CHEMBL1783282 | GABA receptor alpha-2 subunit positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BREXANOLONE | CHEMBL207538 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BROMAZEPAM | CHEMBL277062 | GABA receptor alpha-2 subunit positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL | CHEMBL449 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 80
See all 80 drugsTrials1,181
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07602400 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07602400 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07584902 | CIPEPOFOL | ClinicalTrials.gov | ||
| NCT07584902 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07569198 | MIDAZOLAM | PHASE2 | ClinicalTrials.gov | |
| NCT07568938 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07560878 | LORAZEPAM | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07532733 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07513870 | SEVOFLURANE | ClinicalTrials.gov |
1 to 10 of 1,181
See all 1,181 trialsNIH grants1,409
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABRA2 papers | Newest fiscal year |
|---|---|---|---|
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 69 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 14 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 9 | 2025 |
| P50AA022537 | Cross-species investigation of gene networks for ethanol-related behaviors | 8 | 2025 |
| P60AA007611 | Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol | 8 | 2025 |
| T32AA007477 | Multidisciplinary Alcoholism Research Training Program | 7 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 6 | 2025 |
| P60AA006420 | CNS Effects of Alcohol: Cellular Neurobiology | 4 | 2025 |
| R01AA012404 | Gene Expression in the Human Alcoholic Brain | 4 | 2025 |
| T32AA007459 | Alcohol Intervention Treatment Outcome Research Training | 4 | 2025 |
1 to 10 of 1,409Source NIH's project files
See all 1,409 nih grantsPapers1,001
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A Cross-Matrix Peripheral Transcriptional Signature in Suicide Attempt: NR3C2 Downregulation in Blood and Buccal Swab Samples. | Int J Mol Sci | 2026 | 42653190 | PubTator, text mining | PubMed |
| Epigenetic Regulation of Modulatory Neurotransmitter System Integrity in the Aging Brain: A Scoping Review Across the Lifespan. | Life (Basel) | 2026 | 42514192 | PubTator, text mining | PubMed |
| Exploratory Analysis of Genetic Variants in BDNF, GABA Receptors, and Dopaminergic Pathways with Alcohol Use Disorder in a Spanish Cohort. | Int J Mol Sci | 2026 | 42353097 | PubTator, text mining | PubMed |
Integration of network toxicology, WGCNA, and explainable machine learning to decipher the toxic molecular basis underlying DEGDB plasticizer-induced clear cell renal cell carcinoma (ccRCC) progression. | Comput Biol Chem | 2026 | 42224996 | PubTator, text mining | PubMed |
| Neuroimmunological Mechanisms of Xiao-Yao-San Against Chronic Stress-Induced Colorectal Cancer: A Bioinformatics and Single-Cell Sequencing Study. | Cancer Manag Res | 2026 | 41798904 | PubTator, text mining | PubMed |
| Targeting molecular pathways in neuropathic cancer pain: from mechanisms to novel therapeutics. | iScience | 2026 | 41782818 | PubTator, text mining | PubMed |
| The potential of event-related beta oscillations as biomarkers for neuromodulatory treatment efficacy. | Front Psychol | 2026 | 41756488 | PubTator, text mining | PubMed |
| Integrated Transcriptomic and Histological Analysis of TP53/CTNNB1 Mutations and Microvascular Invasion in Hepatocellular Carcinoma. | Genes (Basel) | 2026 | 41751574 | PubTator, text mining | PubMed |
| Genomic insights into substance use and disinhibitory disorders. | medRxiv | 2026 | 41728329 | PubTator, text mining | PubMed |
| Case Report: A female case of X-linked intellectual disability syndrome type 34 caused by a NONO frameshift variant and literature review. | Front Pediatr | 2026 | 41727761 | PubTator, text mining | PubMed |
1 to 10 of 1,001
See all 1,001 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2555
GET https://conductscience.org/api/genes/v1/2555/patents?page=2