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Gene · 2556

GABRA3: gamma-aminobutyric acid type A receptor subunit alpha3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRA3: gamma-aminobutyric acid type A receptor subunit alpha3. Genes, record 2556. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2556

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Gene

Symbol
GABRA3
HGNC
Name
gamma-aminobutyric acid type A receptor subunit alpha3
HGNC
NCBI Gene ID
2556
NCBI Gene
HGNC ID
HGNC:4077
HGNC
Ensembl
ENSG00000011677
NCBI Gene
Aliases
EPILX2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P34903Gamma-aminobutyric acid receptor subunit alpha-34921Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447235P34903Espacenet
JP 2026004568 A2026-01-1447236P34903Espacenet
JP 2026004568 A2026-01-1447238P34903Espacenet
EP 4650780 A22025-11-198759P34903Espacenet
EP 4641201 A22025-10-298954P34903Espacenet
JP 2025529142 A2025-09-041654P34903Espacenet
US 12371689 B22025-07-291654P34903Espacenet
JP 2025517969 A2025-06-128954P34903Espacenet
JP 2025517970 A2025-06-128759P34903Espacenet
EP 4551941 A22025-05-143P34903Espacenet

1 to 10 of 35

See all 35 patents

Drugs79

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
AZD6280CHEMBL1783256GABA receptor alpha-3 subunit positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
AZD7325CHEMBL1783282GABA receptor alpha-3 subunit positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITAL SODIUMCHEMBL1200982GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 79

See all 79 drugs

Trials1,181

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants501

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRA3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant32025
P30CA010815Consolidated Basic Cancer Research Program32025
ZIAAA000301Integrative genetics of behavior with high throughput technologies32025
P50AA010761Alcohol Research Center - Treatment and Implications22025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology22025
R01AA012404Gene Expression in the Human Alcoholic Brain22025
R28AA012725Brain Tissue Resource Center for Alcohol Research22025
U01AA0209262/11 Spatially Resolved, Single Cell, Neuroimmune Transcriptomes in Alcohol Dependence22025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).22025
UL1TR001863Yale Clinical and Translational Science Award22025

1 to 10 of 501Source NIH's project files

See all 501 nih grants

Papers612

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain.Nat Commun202641917044PubTator, text miningPubMed
MuTriM: A multiscale deep learning model integrating longitudinal radiomics and pathomic features for predicting recurrence and adjuvant radiation benefit in breast cancer.Eur J Cancer202641850009PubTator, text miningPubMed
Evolution of Engineered ADAR-Based RNA Editing Systems.Int J Mol Sci202641751993PubTator, text miningPubMed
Integrated Transcriptomic and Histological Analysis of TP53/CTNNB1 Mutations and Microvascular Invasion in Hepatocellular Carcinoma.Genes (Basel)202641751574PubTator, text miningPubMed
Integrated Clinical Genetic Analysis Reveals Transcriptional Neurotransmitter Receptor Dysregulation in Meningiomas Causing Seizure.Neurosurgery202641677355PubTator, text miningPubMed
Mechanism of action of piperine in the treatment of retinal ischemic injury based on bioinformatics and network pharmacology.Eur J Pharmacol202641651335PubTator, text miningPubMed
Multi-omics and transcriptomic profiling of anesthetic response reveals RNA regulatory networks in postoperative nausea and vomiting.SLAS Technol202641544998PubTator, text miningPubMed
The association between exposure to phthalates and cardiovascular disease: A comprehensive study utilizing NHANES data from 2005 to 2018 and network toxicology.Chem Biol Interact202540653100PubTator, text miningPubMed
Long-term treatment with benzodiazepines and related Z-drugs exacerbates breast cancer: clinical evidence and molecular mechanisms.Cell Mol Biol Lett202540583063PubTator, text miningPubMed
Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review.Front Public Health202540376058PubTator, text miningPubMed

1 to 10 of 612

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2556

GET https://conductscience.org/api/genes/v1/2556/patents?page=2