Gene · 2557
GABRA4: gamma-aminobutyric acid type A receptor subunit alpha4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABRA4: gamma-aminobutyric acid type A receptor subunit alpha4. Genes, record 2557. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2557
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | 554 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47239 | P48169 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2340 | P48169 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1901 | P48169 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1655 | P48169 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1655 | P48169 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1901 | P48169 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2340 | P48169 | Espacenet |
| EP 4551941 A2 | 2025-05-14 | 4 | P48169 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 28751 | P48169 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 28751 | P48169 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs78
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABP-700 | CHEMBL4297255 | GABA-A receptor; anion channel agonist | AGONIST | ChEMBL |
| ACAMPROSATE | CHEMBL1201293 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ADIPIPLON | CHEMBL2103791 | GABA-A receptor; anion channel partial agonist | PARTIAL AGONIST | ChEMBL |
| ALPRAZOLAM | CHEMBL661 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BREXANOLONE | CHEMBL207538 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL | CHEMBL449 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL SODIUM | CHEMBL1200982 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTALBITAL | CHEMBL454 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 78
See all 78 drugsTrials1,198
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07602400 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07602400 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07584902 | CIPEPOFOL | ClinicalTrials.gov | ||
| NCT07584902 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07569198 | MIDAZOLAM | PHASE2 | ClinicalTrials.gov | |
| NCT07568938 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07560878 | LORAZEPAM | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07532733 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07513870 | SEVOFLURANE | ClinicalTrials.gov |
1 to 10 of 1,198
See all 1,198 trialsNIH grants638
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABRA4 papers | Newest fiscal year |
|---|---|---|---|
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 9 | 2025 |
| P60AA011605 | Molecular and Circuit Pathogenesis of Alcohol Use Disorders | 4 | 2025 |
| K01AA030083 | Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches | 3 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 3 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 3 | 2025 |
| DP1DA054394 | Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction | 2 | 2025 |
| I01BX004820 | Genetic Vulnerability for Sustained Multi-Substance Use in MVP | 2 | 2025 |
| K01DA051759 | Identifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics data | 2 | 2025 |
| P60AA010760 | Behavioral Genomics of Alcohol Neuroadaptation | 2 | 2025 |
| R01DA054869 | 7/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact | 2 | 2025 |
1 to 10 of 638Source NIH's project files
See all 638 nih grantsPapers447
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A GABRA4 Variant of the GABA(A) Receptor Located in the Extracellular Domain Potentially Contributes to Developmental Delay and Epilepsy. | Am J Med Genet A | 2026 | 42469594 | PubTator, text mining | PubMed |
| The human GABA A receptor α4 subunit variant Ile114Asn linked to epilepsy impairs membrane expression with β3 and δ subunits. | MicroPubl Biol | 2026 | 42359281 | PubTator, text mining | PubMed |
| Peripheral GABAergic markers in late-life depression: Links to clinical outcomes. | Brain Res | 2026 | 42086139 | PubTator, text mining | PubMed |
| The human GABAA receptor α4 subunit variant Ile114Asn linked to epilepsy impairs membrane expression with β3 and δ subunits. | bioRxiv | 2026 | 42079155 | PubTator, text mining | PubMed |
| Distinct molecular pathways leading to dosage-dependent temozolomide resistance in GBM stem cells. | Cancer Cell Int | 2026 | 41736030 | PubTator, text mining | PubMed |
| A two-sample Mendelian randomization analysis of the impact of GABA receptor subtypes on human height. | Medicine (Baltimore) | 2025 | 41398882 | PubTator, text mining | PubMed |
| Estimation of genome-wide coupling in rattlesnake hybrids provides insight into the process of speciation and its progress. | Nat Commun | 2025 | 41271722 | PubTator, text mining | PubMed |
| Gamma-aminobutyric acid A receptor alpha 4 in the nucleus accumbens mediates cue-induced heroin-seeking behavior in male rats via miR-7b. | Neuroreport | 2025 | 41269988 | PubTator, text mining | PubMed |
| Disrupted synaptic gene expression in Fabry disease: Findings from RNA sequencing. | Neurobiol Dis | 2025 | 40233852 | PubTator, text mining | PubMed |
| Action potential-dependent α4-containing GABAA receptors contribute to epileptogenicity in focal cortical dysplasia. | Epilepsy Res | 2025 | 39919537 | PubTator, text mining | PubMed |
1 to 10 of 447
See all 447 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2557
GET https://conductscience.org/api/genes/v1/2557/patents?page=2