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Gene · 2557

GABRA4: gamma-aminobutyric acid type A receptor subunit alpha4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRA4: gamma-aminobutyric acid type A receptor subunit alpha4. Genes, record 2557. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2557

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Gene

Symbol
GABRA4
HGNC
Name
gamma-aminobutyric acid type A receptor subunit alpha4
HGNC
NCBI Gene ID
2557
NCBI Gene
HGNC ID
HGNC:4078
HGNC
Ensembl
ENSG00000109158
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48169Gamma-aminobutyric acid receptor subunit alpha-45545Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447239P48169Espacenet
EP 4650780 A22025-11-192340P48169Espacenet
EP 4641201 A22025-10-291901P48169Espacenet
JP 2025529142 A2025-09-041655P48169Espacenet
US 12371689 B22025-07-291655P48169Espacenet
JP 2025517969 A2025-06-121901P48169Espacenet
JP 2025517970 A2025-06-122340P48169Espacenet
EP 4551941 A22025-05-144P48169Espacenet
JP 2025032204 A2025-03-1128751P48169Espacenet
EP 4461818 A22024-11-1328751P48169Espacenet

1 to 10 of 31

See all 31 patents

Drugs78

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITAL SODIUMCHEMBL1200982GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTALBITALCHEMBL454GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CENOBAMATECHEMBL3989949GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 78

See all 78 drugs

Trials1,198

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants638

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRA4 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).92025
P60AA011605Molecular and Circuit Pathogenesis of Alcohol Use Disorders42025
K01AA030083Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches32025
P50AA012870Center for the Translational Neuroscience of Alcoholism32025
ZIAAA000301Integrative genetics of behavior with high throughput technologies32025
DP1DA054394Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction22025
I01BX004820Genetic Vulnerability for Sustained Multi-Substance Use in MVP22025
K01DA051759Identifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics data22025
P60AA010760Behavioral Genomics of Alcohol Neuroadaptation22025
R01DA0548697/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact22025

1 to 10 of 638Source NIH's project files

See all 638 nih grants

Papers447

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A GABRA4 Variant of the GABA(A) Receptor Located in the Extracellular Domain Potentially Contributes to Developmental Delay and Epilepsy.Am J Med Genet A202642469594PubTator, text miningPubMed
The human GABA A receptor α4 subunit variant Ile114Asn linked to epilepsy impairs membrane expression with β3 and δ subunits.MicroPubl Biol202642359281PubTator, text miningPubMed
Peripheral GABAergic markers in late-life depression: Links to clinical outcomes.Brain Res202642086139PubTator, text miningPubMed
The human GABAA receptor α4 subunit variant Ile114Asn linked to epilepsy impairs membrane expression with β3 and δ subunits.bioRxiv202642079155PubTator, text miningPubMed
Distinct molecular pathways leading to dosage-dependent temozolomide resistance in GBM stem cells.Cancer Cell Int202641736030PubTator, text miningPubMed
A two-sample Mendelian randomization analysis of the impact of GABA receptor subtypes on human height.Medicine (Baltimore)202541398882PubTator, text miningPubMed
Estimation of genome-wide coupling in rattlesnake hybrids provides insight into the process of speciation and its progress.Nat Commun202541271722PubTator, text miningPubMed
Gamma-aminobutyric acid A receptor alpha 4 in the nucleus accumbens mediates cue-induced heroin-seeking behavior in male rats via miR-7b.Neuroreport202541269988PubTator, text miningPubMed
Disrupted synaptic gene expression in Fabry disease: Findings from RNA sequencing.Neurobiol Dis202540233852PubTator, text miningPubMed
Action potential-dependent α4-containing GABAA receptors contribute to epileptogenicity in focal cortical dysplasia.Epilepsy Res202539919537PubTator, text miningPubMed

1 to 10 of 447

See all 447 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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