Gene · 2558
GABRA5: gamma-aminobutyric acid type A receptor subunit alpha5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABRA5: gamma-aminobutyric acid type A receptor subunit alpha5. Genes, record 2558. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2558
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | 462 | 23 | Ensembl, GeneID, HGNC |
Source UniProt
Patents64
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47240 | P31644 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47241 | P31644 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47242 | P31644 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6186 | P31644 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5948 | P31644 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5690 | P31644 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5691 | P31644 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5692 | P31644 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1656 | P31644 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6440 | P31644 | Espacenet |
1 to 10 of 64
See all 64 patentsDrugs77
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABP-700 | CHEMBL4297255 | GABA-A receptor; anion channel agonist | AGONIST | ChEMBL |
| ACAMPROSATE | CHEMBL1201293 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ADIPIPLON | CHEMBL2103791 | GABA-A receptor; anion channel partial agonist | PARTIAL AGONIST | ChEMBL |
| ALPRAZOLAM | CHEMBL661 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BREXANOLONE | CHEMBL207538 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL | CHEMBL449 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL SODIUM | CHEMBL1200982 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTALBITAL | CHEMBL454 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 77
See all 77 drugsTrials1,176
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07602400 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07602400 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07584902 | CIPEPOFOL | ClinicalTrials.gov | ||
| NCT07584902 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07569198 | MIDAZOLAM | PHASE2 | ClinicalTrials.gov | |
| NCT07568938 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07560878 | LORAZEPAM | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07532733 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07513870 | SEVOFLURANE | ClinicalTrials.gov |
1 to 10 of 1,176
See all 1,176 trialsNIH grants672
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABRA5 papers | Newest fiscal year |
|---|---|---|---|
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 3 | 2025 |
| K12CA090354 | Training Program in Nervous System Tumors | 2 | 2025 |
| P30CA138292 | Winship Cancer Institute Cancer Center Support Grant | 2 | 2025 |
| U19AG063911 | ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2) | 2 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 2 | 2025 |
| F30MH138058 | Sleep as a Mechanism of Premenstrual Exacerbation of Depression and Suicidality | 1 | 2025 |
| I01CX001301 | Effects of ADT on motivation and emotion function in prostate cancer patients: longitudinal imaging and prediction | 1 | 2025 |
| K12GM093857 | Virginia Commonwealth University IRACDA | 1 | 2025 |
| K24AG053435 | Neuropathological changes underlying clinical heterogeneity in Alzheimer disease | 1 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 1 | 2025 |
1 to 10 of 672Source NIH's project files
See all 672 nih grantsPapers684
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrated transcriptomic and metabolomic analysis of the hypothalamic-pituitary-testicular axis in rooster lines with contrasting hatchability. | Poult Sci | 2026 | 42736190 | PubTator, text mining | PubMed |
| Sleep disruption and neuropsychiatric features in Angelman syndrome: insights into underlying neurobiology. | Sleep Med | 2026 | 42607587 | PubTator, text mining | PubMed |
| Identification of key candidate genes for body weight traits in male Dongfeng sika deer based on genome-wide association analysis. | Sci Rep | 2026 | 42277116 | PubTator, text mining | PubMed |
| Association Analysis of GABRA5, SOX13, and AGL Gene Polymorphisms with Growth Traits in Dongfeng Sika Deer. | Biology (Basel) | 2026 | 42274532 | PubTator, text mining | PubMed |
| Peripheral GABAergic markers in late-life depression: Links to clinical outcomes. | Brain Res | 2026 | 42086139 | PubTator, text mining | PubMed |
| Neonatal social communication and single genes predict the variability of post-pubertal social behavior in a mouse model of paternal 15q11-13 duplication. | Res Sq | 2026 | 41756422 | PubTator, text mining | PubMed |
| Genomics of Complex Neurodevelopmental Disorders with Variable Epilepsy Phenotypes: A Clinical Review of Dup15q Syndrome. | Genes (Basel) | 2026 | 41751547 | PubTator, text mining | PubMed |
| COVID-19 immunopathological features for the prediction and prevention of future emerging respiratory viral infections. | Comput Struct Biotechnol J | 2026 | 41551039 | PubTator, text mining | PubMed |
| Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach. | BMC Med | 2026 | 41484767 | PubTator, text mining | PubMed |
| Uncovering common genetic risk factors in migraine and epilepsy through whole exome sequencing. | Epileptic Disord | 2026 | 41386636 | PubTator, text mining | PubMed |
1 to 10 of 684
See all 684 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2558
GET https://conductscience.org/api/genes/v1/2558/patents?page=2