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Gene · 2558

GABRA5: gamma-aminobutyric acid type A receptor subunit alpha5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRA5: gamma-aminobutyric acid type A receptor subunit alpha5. Genes, record 2558. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2558

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Gene

Symbol
GABRA5
HGNC
Name
gamma-aminobutyric acid type A receptor subunit alpha5
HGNC
NCBI Gene ID
2558
NCBI Gene
HGNC ID
HGNC:4079
HGNC
Ensembl
ENSG00000186297
NCBI Gene
Aliases
DEE79, EIEE79
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P31644Gamma-aminobutyric acid receptor subunit alpha-546223Ensembl, GeneID, HGNC

Source UniProt

Patents64

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447240P31644Espacenet
JP 2026004568 A2026-01-1447241P31644Espacenet
JP 2026004568 A2026-01-1447242P31644Espacenet
EP 4650780 A22025-11-196186P31644Espacenet
EP 4641201 A22025-10-295948P31644Espacenet
JP 2025147176 A2025-10-065690P31644Espacenet
JP 2025147176 A2025-10-065691P31644Espacenet
JP 2025147176 A2025-10-065692P31644Espacenet
JP 2025529142 A2025-09-041656P31644Espacenet
JP 2025529142 A2025-09-046440P31644Espacenet

1 to 10 of 64

See all 64 patents

Drugs77

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITAL SODIUMCHEMBL1200982GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTALBITALCHEMBL454GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CENOBAMATECHEMBL3989949GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 77

See all 77 drugs

Trials1,176

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants672

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRA5 papersNewest fiscal year
R28AA012725Brain Tissue Resource Center for Alcohol Research32025
K12CA090354Training Program in Nervous System Tumors22025
P30CA138292Winship Cancer Institute Cancer Center Support Grant22025
U19AG063911ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2)22025
ZIAAA000301Integrative genetics of behavior with high throughput technologies22025
F30MH138058Sleep as a Mechanism of Premenstrual Exacerbation of Depression and Suicidality12025
I01CX001301Effects of ADT on motivation and emotion function in prostate cancer patients: longitudinal imaging and prediction12025
K12GM093857Virginia Commonwealth University IRACDA12025
K24AG053435Neuropathological changes underlying clinical heterogeneity in Alzheimer disease12025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions12025

1 to 10 of 672Source NIH's project files

See all 672 nih grants

Papers684

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated transcriptomic and metabolomic analysis of the hypothalamic-pituitary-testicular axis in rooster lines with contrasting hatchability.Poult Sci202642736190PubTator, text miningPubMed
Sleep disruption and neuropsychiatric features in Angelman syndrome: insights into underlying neurobiology.Sleep Med202642607587PubTator, text miningPubMed
Identification of key candidate genes for body weight traits in male Dongfeng sika deer based on genome-wide association analysis.Sci Rep202642277116PubTator, text miningPubMed
Association Analysis of GABRA5, SOX13, and AGL Gene Polymorphisms with Growth Traits in Dongfeng Sika Deer.Biology (Basel)202642274532PubTator, text miningPubMed
Peripheral GABAergic markers in late-life depression: Links to clinical outcomes.Brain Res202642086139PubTator, text miningPubMed
Neonatal social communication and single genes predict the variability of post-pubertal social behavior in a mouse model of paternal 15q11-13 duplication.Res Sq202641756422PubTator, text miningPubMed
Genomics of Complex Neurodevelopmental Disorders with Variable Epilepsy Phenotypes: A Clinical Review of Dup15q Syndrome.Genes (Basel)202641751547PubTator, text miningPubMed
COVID-19 immunopathological features for the prediction and prevention of future emerging respiratory viral infections.Comput Struct Biotechnol J202641551039PubTator, text miningPubMed
Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach.BMC Med202641484767PubTator, text miningPubMed
Uncovering common genetic risk factors in migraine and epilepsy through whole exome sequencing.Epileptic Disord202641386636PubTator, text miningPubMed

1 to 10 of 684

See all 684 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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