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Gene · 2559

GABRA6: gamma-aminobutyric acid type A receptor subunit alpha6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRA6: gamma-aminobutyric acid type A receptor subunit alpha6. Genes, record 2559. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2559

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Gene

Symbol
GABRA6
HGNC
Name
gamma-aminobutyric acid type A receptor subunit alpha6
HGNC
NCBI Gene ID
2559
NCBI Gene
HGNC ID
HGNC:4080
HGNC
Ensembl
ENSG00000145863
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16445Gamma-aminobutyric acid receptor subunit alpha-64530Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447247Q16445Espacenet
EP 4650780 A22025-11-192913Q16445Espacenet
EP 4641201 A22025-10-292475Q16445Espacenet
JP 2025529142 A2025-09-041657Q16445Espacenet
US 12371689 B22025-07-291657Q16445Espacenet
JP 2025517969 A2025-06-122475Q16445Espacenet
JP 2025517970 A2025-06-122913Q16445Espacenet
EP 4551941 A22025-05-146Q16445Espacenet
JP 2025032204 A2025-03-1128755Q16445Espacenet
EP 4461818 A22024-11-1328755Q16445Espacenet

1 to 10 of 22

See all 22 patents

Drugs77

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITAL SODIUMCHEMBL1200982GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTALBITALCHEMBL454GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CENOBAMATECHEMBL3989949GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 77

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Trials1,176

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants568

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRA6 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).62025
ZIAAA000301Integrative genetics of behavior with high throughput technologies62025
R01AA012404Gene Expression in the Human Alcoholic Brain42025
P30CA016672Cancer Center Support Grant32025
R28AA012725Brain Tissue Resource Center for Alcohol Research32025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant22025
P30CA047904Cancer Center Support Grant22025
P30DA018310Neurometabolomics and Neuroproteomics Center on Cell-Cell Signaling22025
P50AA012870Center for the Translational Neuroscience of Alcoholism22025
U01AA0209262/11 Spatially Resolved, Single Cell, Neuroimmune Transcriptomes in Alcohol Dependence22025

1 to 10 of 568Source NIH's project files

See all 568 nih grants

Papers471

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exploratory Analysis of Genetic Variants in BDNF, GABA Receptors, and Dopaminergic Pathways with Alcohol Use Disorder in a Spanish Cohort.Int J Mol Sci202642353097PubTator, text miningPubMed
Molecular Characterization of Biphasic Follicular Dendritic Cell Sarcoma.Appl Immunohistochem Mol Morphol202641943444PubTator, text miningPubMed
Prenatal diagnosis and molecular cytogenetic characterization of a 1.244-Mb 5q34 deletion encompassing GABRB2, GABRA6, GABRA1 and GABRG2 in a fetus with an aberrant chromosome 5 or add(5)(q33.1) at amniocentesis.
Taiwan J Obstet Gynecol202641617324PubTator, text miningPubMed
Unravelling the role of cerebellar α6GABAA receptors in anti-tremor pharmacotherapies.Biomed Pharmacother202541130093PubTator, text miningPubMed
Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy.Acta Neuropathol Commun202540993824PubTator, text miningPubMed
Corrigendum to "Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol" [Psychoneuroendocrinology (2025) 107358].Psychoneuroendocrinology202539955882PubTator, text miningPubMed
Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample.Risk Manag Healthc Policy202539882063PubTator, text miningPubMed
Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol.Psychoneuroendocrinology202539864119PubTator, text miningPubMed
Single-Nucleus RNA Sequencing Reveals That Gabra6+ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave-Induced TBI.Adv Sci (Weinh)202539665190PubTator, text miningPubMed
Synaptic Structure and Transcriptomic Profiling of Reward and Sensory Brain Areas in Male Mice of Fentanyl Addiction.Subst Abuse Rehabil202439659661PubTator, text miningPubMed

1 to 10 of 471

See all 471 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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