Gene · 2559
GABRA6: gamma-aminobutyric acid type A receptor subunit alpha6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABRA6: gamma-aminobutyric acid type A receptor subunit alpha6. Genes, record 2559. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2559
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | 453 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47247 | Q16445 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2913 | Q16445 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2475 | Q16445 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1657 | Q16445 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1657 | Q16445 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2475 | Q16445 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2913 | Q16445 | Espacenet |
| EP 4551941 A2 | 2025-05-14 | 6 | Q16445 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 28755 | Q16445 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 28755 | Q16445 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs77
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABP-700 | CHEMBL4297255 | GABA-A receptor; anion channel agonist | AGONIST | ChEMBL |
| ACAMPROSATE | CHEMBL1201293 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ADIPIPLON | CHEMBL2103791 | GABA-A receptor; anion channel partial agonist | PARTIAL AGONIST | ChEMBL |
| ALPRAZOLAM | CHEMBL661 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BREXANOLONE | CHEMBL207538 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL | CHEMBL449 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL SODIUM | CHEMBL1200982 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTALBITAL | CHEMBL454 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 77
See all 77 drugsTrials1,176
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07602400 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07602400 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07584902 | CIPEPOFOL | ClinicalTrials.gov | ||
| NCT07584902 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07569198 | MIDAZOLAM | PHASE2 | ClinicalTrials.gov | |
| NCT07568938 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07560878 | LORAZEPAM | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07532733 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07513870 | SEVOFLURANE | ClinicalTrials.gov |
1 to 10 of 1,176
See all 1,176 trialsNIH grants568
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABRA6 papers | Newest fiscal year |
|---|---|---|---|
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 6 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 6 | 2025 |
| R01AA012404 | Gene Expression in the Human Alcoholic Brain | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 3 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 2 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 2 | 2025 |
| P30DA018310 | Neurometabolomics and Neuroproteomics Center on Cell-Cell Signaling | 2 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 2 | 2025 |
| U01AA020926 | 2/11 Spatially Resolved, Single Cell, Neuroimmune Transcriptomes in Alcohol Dependence | 2 | 2025 |
1 to 10 of 568Source NIH's project files
See all 568 nih grantsPapers471
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Exploratory Analysis of Genetic Variants in BDNF, GABA Receptors, and Dopaminergic Pathways with Alcohol Use Disorder in a Spanish Cohort. | Int J Mol Sci | 2026 | 42353097 | PubTator, text mining | PubMed |
| Molecular Characterization of Biphasic Follicular Dendritic Cell Sarcoma. | Appl Immunohistochem Mol Morphol | 2026 | 41943444 | PubTator, text mining | PubMed |
Prenatal diagnosis and molecular cytogenetic characterization of a 1.244-Mb 5q34 deletion encompassing GABRB2, GABRA6, GABRA1 and GABRG2 in a fetus with an aberrant chromosome 5 or add(5)(q33.1) at amniocentesis. | Taiwan J Obstet Gynecol | 2026 | 41617324 | PubTator, text mining | PubMed |
| Unravelling the role of cerebellar α6GABAA receptors in anti-tremor pharmacotherapies. | Biomed Pharmacother | 2025 | 41130093 | PubTator, text mining | PubMed |
| Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy. | Acta Neuropathol Commun | 2025 | 40993824 | PubTator, text mining | PubMed |
| Corrigendum to "Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol" [Psychoneuroendocrinology (2025) 107358]. | Psychoneuroendocrinology | 2025 | 39955882 | PubTator, text mining | PubMed |
| Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample. | Risk Manag Healthc Policy | 2025 | 39882063 | PubTator, text mining | PubMed |
| Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol. | Psychoneuroendocrinology | 2025 | 39864119 | PubTator, text mining | PubMed |
| Single-Nucleus RNA Sequencing Reveals That Gabra6+ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave-Induced TBI. | Adv Sci (Weinh) | 2025 | 39665190 | PubTator, text mining | PubMed |
| Synaptic Structure and Transcriptomic Profiling of Reward and Sensory Brain Areas in Male Mice of Fentanyl Addiction. | Subst Abuse Rehabil | 2024 | 39659661 | PubTator, text mining | PubMed |
1 to 10 of 471
See all 471 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2559
GET https://conductscience.org/api/genes/v1/2559/patents?page=2