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Gene · 2560

GABRB1: gamma-aminobutyric acid type A receptor subunit beta1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRB1: gamma-aminobutyric acid type A receptor subunit beta1. Genes, record 2560. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2560

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Gene

Symbol
GABRB1
HGNC
Name
gamma-aminobutyric acid type A receptor subunit beta1
HGNC
NCBI Gene ID
2560
NCBI Gene
HGNC ID
HGNC:4081
HGNC
Ensembl
ENSG00000163288
NCBI Gene
Aliases
DEE45, EIEE45
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18505Gamma-aminobutyric acid receptor subunit beta-14743Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447249P18505Espacenet
EP 4650780 A22025-11-193618P18505Espacenet
EP 4641201 A22025-10-293213P18505Espacenet
JP 2025529142 A2025-09-041658P18505Espacenet
US 12371689 B22025-07-291658P18505Espacenet
JP 2025517969 A2025-06-123213P18505Espacenet
JP 2025517970 A2025-06-123618P18505Espacenet
EP 4551941 A22025-05-147P18505Espacenet
JP 2025032204 A2025-03-1128761P18505Espacenet
EP 4461818 A22024-11-1328761P18505Espacenet

1 to 10 of 22

See all 22 patents

Drugs80

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITAL SODIUMCHEMBL1200982GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTALBITALCHEMBL454GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CENOBAMATECHEMBL3989949GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 80

See all 80 drugs

Trials1,242

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants707

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRB1 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).102025
ZIAAA000301Integrative genetics of behavior with high throughput technologies42025
P50AA012870Center for the Translational Neuroscience of Alcoholism32025
R01AA012404Gene Expression in the Human Alcoholic Brain32025
P30CA138292Winship Cancer Institute Cancer Center Support Grant22025
P30ES023515Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS)22025
R01EB006841Multivariate methods for identifying multitask/multimodal brain imaging biomarkers22025
R28AA012725Brain Tissue Resource Center for Alcohol Research22025
UL1TR001863Yale Clinical and Translational Science Award22025
I01CX001301Effects of ADT on motivation and emotion function in prostate cancer patients: longitudinal imaging and prediction12025

1 to 10 of 707Source NIH's project files

See all 707 nih grants

Papers524

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic landscape of patients with atypical absence status epilepticus: A systematic review.Epilepsia Open202642112912PubTator, text miningPubMed
A functional MeCP2-LBX1 axis regulates neuronal gene expression in neuronal cells.Biochem Biophys Res Commun202642054896PubTator, text miningPubMed
Functional β1-selectivity of novel pyrazoloquinolinones at GABAA receptors revealed by electrophysiology, mutagenesis and docking.Eur J Pharmacol202642009093PubTator, text miningPubMed
Learning heritable multimodal brain representation via contrastive learning.bioRxiv202641756892PubTator, text miningPubMed
Distinct molecular pathways leading to dosage-dependent temozolomide resistance in GBM stem cells.Cancer Cell Int202641736030PubTator, text miningPubMed
Causal Implication of CD52-Driven Immune Dysregulation in Sarcopenic Obesity: Integrating Mendelian Randomization and Multiomics Profiling.Clin Interv Aging202641726179PubTator, text miningPubMed
Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation.Sci Adv202641706855PubTator, text miningPubMed
Screening natural raw materials and product development for improving insomnia based on network pharmacology and data mining.Medicine (Baltimore)202641578474PubTator, text miningPubMed
Epigenetic Landscapes of Methamphetamine Addiction: Unravelling the Diagnostic Potential of Gene Methylation.Addict Biol202541368944PubTator, text miningPubMed
Estimation of genome-wide coupling in rattlesnake hybrids provides insight into the process of speciation and its progress.Nat Commun202541271722PubTator, text miningPubMed

1 to 10 of 524

See all 524 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2560

GET https://conductscience.org/api/genes/v1/2560/patents?page=2