Gene · 2560
GABRB1: gamma-aminobutyric acid type A receptor subunit beta1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABRB1: gamma-aminobutyric acid type A receptor subunit beta1. Genes, record 2560. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2560
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | 474 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47249 | P18505 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3618 | P18505 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3213 | P18505 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1658 | P18505 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1658 | P18505 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3213 | P18505 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3618 | P18505 | Espacenet |
| EP 4551941 A2 | 2025-05-14 | 7 | P18505 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 28761 | P18505 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 28761 | P18505 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs80
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABP-700 | CHEMBL4297255 | GABA-A receptor; anion channel agonist | AGONIST | ChEMBL |
| ACAMPROSATE | CHEMBL1201293 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ADIPIPLON | CHEMBL2103791 | GABA-A receptor; anion channel partial agonist | PARTIAL AGONIST | ChEMBL |
| ALPRAZOLAM | CHEMBL661 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BREXANOLONE | CHEMBL207538 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL | CHEMBL449 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL SODIUM | CHEMBL1200982 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTALBITAL | CHEMBL454 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 80
See all 80 drugsTrials1,242
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07602400 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07602400 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07584902 | CIPEPOFOL | ClinicalTrials.gov | ||
| NCT07584902 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07569198 | MIDAZOLAM | PHASE2 | ClinicalTrials.gov | |
| NCT07568938 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07560878 | LORAZEPAM | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07532733 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07513870 | SEVOFLURANE | ClinicalTrials.gov |
1 to 10 of 1,242
See all 1,242 trialsNIH grants707
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABRB1 papers | Newest fiscal year |
|---|---|---|---|
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 10 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 4 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 3 | 2025 |
| R01AA012404 | Gene Expression in the Human Alcoholic Brain | 3 | 2025 |
| P30CA138292 | Winship Cancer Institute Cancer Center Support Grant | 2 | 2025 |
| P30ES023515 | Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS) | 2 | 2025 |
| R01EB006841 | Multivariate methods for identifying multitask/multimodal brain imaging biomarkers | 2 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 2 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 2 | 2025 |
| I01CX001301 | Effects of ADT on motivation and emotion function in prostate cancer patients: longitudinal imaging and prediction | 1 | 2025 |
1 to 10 of 707Source NIH's project files
See all 707 nih grantsPapers524
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Genetic landscape of patients with atypical absence status epilepticus: A systematic review. | Epilepsia Open | 2026 | 42112912 | PubTator, text mining | PubMed |
| A functional MeCP2-LBX1 axis regulates neuronal gene expression in neuronal cells. | Biochem Biophys Res Commun | 2026 | 42054896 | PubTator, text mining | PubMed |
| Functional β1-selectivity of novel pyrazoloquinolinones at GABAA receptors revealed by electrophysiology, mutagenesis and docking. | Eur J Pharmacol | 2026 | 42009093 | PubTator, text mining | PubMed |
| Learning heritable multimodal brain representation via contrastive learning. | bioRxiv | 2026 | 41756892 | PubTator, text mining | PubMed |
| Distinct molecular pathways leading to dosage-dependent temozolomide resistance in GBM stem cells. | Cancer Cell Int | 2026 | 41736030 | PubTator, text mining | PubMed |
| Causal Implication of CD52-Driven Immune Dysregulation in Sarcopenic Obesity: Integrating Mendelian Randomization and Multiomics Profiling. | Clin Interv Aging | 2026 | 41726179 | PubTator, text mining | PubMed |
| Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation. | Sci Adv | 2026 | 41706855 | PubTator, text mining | PubMed |
| Screening natural raw materials and product development for improving insomnia based on network pharmacology and data mining. | Medicine (Baltimore) | 2026 | 41578474 | PubTator, text mining | PubMed |
| Epigenetic Landscapes of Methamphetamine Addiction: Unravelling the Diagnostic Potential of Gene Methylation. | Addict Biol | 2025 | 41368944 | PubTator, text mining | PubMed |
| Estimation of genome-wide coupling in rattlesnake hybrids provides insight into the process of speciation and its progress. | Nat Commun | 2025 | 41271722 | PubTator, text mining | PubMed |
1 to 10 of 524
See all 524 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2560
GET https://conductscience.org/api/genes/v1/2560/patents?page=2