Gene · 2561
GABRB2: gamma-aminobutyric acid type A receptor subunit beta2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABRB2: gamma-aminobutyric acid type A receptor subunit beta2. Genes, record 2561. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2561
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | 512 | 31 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47251 | P47870 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47253 | P47870 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2915 | P47870 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2477 | P47870 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1659 | P47870 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1659 | P47870 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2477 | P47870 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2915 | P47870 | Espacenet |
| EP 4551941 A2 | 2025-05-14 | 8 | P47870 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 33924 | P47870 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs77
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABP-700 | CHEMBL4297255 | GABA-A receptor; anion channel agonist | AGONIST | ChEMBL |
| ACAMPROSATE | CHEMBL1201293 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ADIPIPLON | CHEMBL2103791 | GABA-A receptor; anion channel partial agonist | PARTIAL AGONIST | ChEMBL |
| ALPRAZOLAM | CHEMBL661 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BREXANOLONE | CHEMBL207538 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL | CHEMBL449 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL SODIUM | CHEMBL1200982 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTALBITAL | CHEMBL454 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 77
See all 77 drugsTrials1,176
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07602400 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07602400 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07584902 | CIPEPOFOL | ClinicalTrials.gov | ||
| NCT07584902 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07569198 | MIDAZOLAM | PHASE2 | ClinicalTrials.gov | |
| NCT07568938 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07560878 | LORAZEPAM | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07532733 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07513870 | SEVOFLURANE | ClinicalTrials.gov |
1 to 10 of 1,176
See all 1,176 trialsNIH grants794
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABRB2 papers | Newest fiscal year |
|---|---|---|---|
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 6 | 2025 |
| R01NS105789 | Understanding GABAA receptor protein folding and misfolding | 4 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 3 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 3 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 2 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 2 | 2025 |
| P60AA006420 | CNS Effects of Alcohol: Cellular Neurobiology | 2 | 2025 |
| R01AA012404 | Gene Expression in the Human Alcoholic Brain | 2 | 2025 |
| R01EB006841 | Multivariate methods for identifying multitask/multimodal brain imaging biomarkers | 2 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 2 | 2025 |
1 to 10 of 794Source NIH's project files
See all 794 nih grantsPapers693
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Dose-related propofol resistance in COVID-19 patients: Altered drug plasma levels, mechanistic insights from neuronal-derived extracellular vesicles and miRNA analysis. | Br J Clin Pharmacol | 2026 | 42755063 | PubTator, text mining | PubMed |
| Integrated bioinformatics analysis of chromosomal deletion regions in glioblastoma identifies key genes linked to GABA(A) receptor signaling. | J Biomol Struct Dyn | 2026 | 42752294 | PubTator, text mining | PubMed |
| Exploring sex differences in endocannabinoid system biomarkers and their relationship with antidepressant treatment outcomes in major depressive disorder: a CAN-BIND 1 secondary analysis. | Eur Arch Psychiatry Clin Neurosci | 2026 | 42640306 | PubTator, text mining | PubMed |
| Accurate prediction of gain- and loss-of-function missense variants in GABAA receptors. | EBioMedicine | 2026 | 42546502 | PubTator, text mining | PubMed |
| Exploring the Molecular Mechanisms of Autism Induced by Early Childhood Exposure to Bisphenol A Based on Network Toxicology and Molecular Docking. | Int J Mol Sci | 2026 | 42511660 | PubTator, text mining | PubMed |
| Autism Spectrum Disorder-Associated Genes Enrich in Discrete Cortical, Limbic and Cerebellar Brain Regions. | Eur J Neurosci | 2026 | 42499009 | PubTator, text mining | PubMed |
| Integrated bulk and single-cell RNA sequencing reveals a prognostic neuro-mimicry signature in papillary thyroid carcinoma. | Discov Oncol | 2026 | 42329337 | PubTator, text mining | PubMed |
| A seven-gene diagnostic and prognostic signature for papillary thyroid carcinoma. | Discov Oncol | 2026 | 42323761 | PubTator, text mining | PubMed |
Deciphering the molecular network of Trichostatin A in regulating Alzheimer's disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation. | PLoS One | 2026 | 42008415 | PubTator, text mining | PubMed |
| Learning heritable multimodal brain representation via contrastive learning. | bioRxiv | 2026 | 41756892 | PubTator, text mining | PubMed |
1 to 10 of 693
See all 693 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2561
GET https://conductscience.org/api/genes/v1/2561/patents?page=2