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Gene · 2561

GABRB2: gamma-aminobutyric acid type A receptor subunit beta2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRB2: gamma-aminobutyric acid type A receptor subunit beta2. Genes, record 2561. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2561

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Gene

Symbol
GABRB2
HGNC
Name
gamma-aminobutyric acid type A receptor subunit beta2
HGNC
NCBI Gene ID
2561
NCBI Gene
HGNC ID
HGNC:4082
HGNC
Ensembl
ENSG00000145864
NCBI Gene
Aliases
DEE92, ICEE2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P47870Gamma-aminobutyric acid receptor subunit beta-251231Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447251P47870Espacenet
JP 2026004568 A2026-01-1447253P47870Espacenet
EP 4650780 A22025-11-192915P47870Espacenet
EP 4641201 A22025-10-292477P47870Espacenet
JP 2025529142 A2025-09-041659P47870Espacenet
US 12371689 B22025-07-291659P47870Espacenet
JP 2025517969 A2025-06-122477P47870Espacenet
JP 2025517970 A2025-06-122915P47870Espacenet
EP 4551941 A22025-05-148P47870Espacenet
US 11446398 B22022-09-2033924P47870Espacenet

1 to 10 of 26

See all 26 patents

Drugs77

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITAL SODIUMCHEMBL1200982GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTALBITALCHEMBL454GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CENOBAMATECHEMBL3989949GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 77

See all 77 drugs

Trials1,176

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants794

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRB2 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).62025
R01NS105789Understanding GABAA receptor protein folding and misfolding42025
P50AA012870Center for the Translational Neuroscience of Alcoholism32025
ZIAAA000301Integrative genetics of behavior with high throughput technologies32025
P30DK020572Michigan Diabetes Research Center (MDRC)22025
P30DK063491Diabetes Research Center (DRC)22025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology22025
R01AA012404Gene Expression in the Human Alcoholic Brain22025
R01EB006841Multivariate methods for identifying multitask/multimodal brain imaging biomarkers22025
R28AA012725Brain Tissue Resource Center for Alcohol Research22025

1 to 10 of 794Source NIH's project files

See all 794 nih grants

Papers693

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dose-related propofol resistance in COVID-19 patients: Altered drug plasma levels, mechanistic insights from neuronal-derived extracellular vesicles and miRNA analysis.Br J Clin Pharmacol202642755063PubTator, text miningPubMed
Integrated bioinformatics analysis of chromosomal deletion regions in glioblastoma identifies key genes linked to GABA(A) receptor signaling.J Biomol Struct Dyn202642752294PubTator, text miningPubMed
Exploring sex differences in endocannabinoid system biomarkers and their relationship with antidepressant treatment outcomes in major depressive disorder: a CAN-BIND 1 secondary analysis.Eur Arch Psychiatry Clin Neurosci202642640306PubTator, text miningPubMed
Accurate prediction of gain- and loss-of-function missense variants in GABAA receptors.EBioMedicine202642546502PubTator, text miningPubMed
Exploring the Molecular Mechanisms of Autism Induced by Early Childhood Exposure to Bisphenol A Based on Network Toxicology and Molecular Docking.Int J Mol Sci202642511660PubTator, text miningPubMed
Autism Spectrum Disorder-Associated Genes Enrich in Discrete Cortical, Limbic and Cerebellar Brain Regions.Eur J Neurosci202642499009PubTator, text miningPubMed
Integrated bulk and single-cell RNA sequencing reveals a prognostic neuro-mimicry signature in papillary thyroid carcinoma.Discov Oncol202642329337PubTator, text miningPubMed
A seven-gene diagnostic and prognostic signature for papillary thyroid carcinoma.Discov Oncol202642323761PubTator, text miningPubMed
Deciphering the molecular network of Trichostatin A in regulating Alzheimer's disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation.
PLoS One202642008415PubTator, text miningPubMed
Learning heritable multimodal brain representation via contrastive learning.bioRxiv202641756892PubTator, text miningPubMed

1 to 10 of 693

See all 693 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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