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Gene · 2562

GABRB3: gamma-aminobutyric acid type A receptor subunit beta3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRB3: gamma-aminobutyric acid type A receptor subunit beta3. Genes, record 2562. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2562

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Gene

Symbol
GABRB3
HGNC
Name
gamma-aminobutyric acid type A receptor subunit beta3
HGNC
NCBI Gene ID
2562
NCBI Gene
HGNC ID
HGNC:4083
HGNC
Ensembl
ENSG00000166206
NCBI Gene
Aliases
DEE43, ECA5, EIEE43
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P28472Gamma-aminobutyric acid receptor subunit beta-347397Ensembl, GeneID, HGNC

Source UniProt

Patents47

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082870 A2026-05-198P28472Espacenet
JP 2026004568 A2026-01-1447258P28472Espacenet
EP 4650780 A22025-11-194574P28472Espacenet
EP 4641201 A22025-10-294131P28472Espacenet
JP 2025529142 A2025-09-041660P28472Espacenet
US 12371689 B22025-07-291660P28472Espacenet
JP 2025517969 A2025-06-124131P28472Espacenet
JP 2025517970 A2025-06-124574P28472Espacenet
JP 2025508427 A2025-03-268P28472Espacenet
JP 2025508429 A2025-03-268P28472Espacenet

1 to 10 of 47

See all 47 patents

Drugs79

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITAL SODIUMCHEMBL1200982GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTALBITALCHEMBL454GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CENOBAMATECHEMBL3989949GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 79

See all 79 drugs

Trials1,199

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,541

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRB3 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).52025
P60AA007611Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol42025
R01ES014901Molecular and Cellular Basis of PCB Developmental Neurotoxicity42025
T32GM007748Training Grant in Genetics42025
ZIAAA000301Integrative genetics of behavior with high throughput technologies42025
P50AA012870Center for the Translational Neuroscience of Alcoholism32025
R01MH110438Novel Developmental Pathways Underlying Psychiatric Disorders32025
T32ES007059Advanced Training in Environmental Health Sciences32025
U19AG023122Longevity Consortium32025
P30AG066511Goizueta Alzheimer's Disease Research Center22025

1 to 10 of 1,541Source NIH's project files

See all 1,541 nih grants

Papers1,509

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical Utility of Trio Exome Sequencing in Rwandan Children With Autism Spectrum Disorder.Mol Genet Genomic Med202642742375PubTator, text miningPubMed
Sleep disruption and neuropsychiatric features in Angelman syndrome: insights into underlying neurobiology.Sleep Med202642607587PubTator, text miningPubMed
Accurate prediction of gain- and loss-of-function missense variants in GABAA receptors.EBioMedicine202642546502PubTator, text miningPubMed
Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis.Cell Death Dis202642034645PubTator, text miningPubMed
GABRB3 Gene Polymorphisms Influences the Analgesic Response to Acupuncture Treatment in Patients With Chronic Knee Pain: A Randomized Controlled Neuroimaging Transcriptomics Study.FASEB J202641999225PubTator, text miningPubMed
Genetic Influences on Disease-Modifying Therapy Response in Multiple Sclerosis: Current Insights and Future Directions.Balkan Med J202641918263PubTator, text miningPubMed
In-depth Genetic and Molecular Characterization of Unilateral Coexisting Adrenal Cortical Adenoma and Carcinoma in the Context of MEN1 Syndrome.Endocr Pathol202641806143PubTator, text miningPubMed
Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex.bioRxiv202641757081PubTator, text miningPubMed
Learning heritable multimodal brain representation via contrastive learning.bioRxiv202641756892PubTator, text miningPubMed
Neonatal social communication and single genes predict the variability of post-pubertal social behavior in a mouse model of paternal 15q11-13 duplication.Res Sq202641756422PubTator, text miningPubMed

1 to 10 of 1,509

See all 1,509 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2562

GET https://conductscience.org/api/genes/v1/2562/patents?page=2