Gene · 2563
GABRD: gamma-aminobutyric acid type A receptor subunit delta
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABRD: gamma-aminobutyric acid type A receptor subunit delta. Genes, record 2563. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2563
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14764 | Gamma-aminobutyric acid receptor subunit delta | 452 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47262 | O14764 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10060 | O14764 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10340 | O14764 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1661 | O14764 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6441 | O14764 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1661 | O14764 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6441 | O14764 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10340 | O14764 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10060 | O14764 | Espacenet |
| EP 4551941 A2 | 2025-05-14 | 10 | O14764 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs77
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABP-700 | CHEMBL4297255 | GABA-A receptor; anion channel agonist | AGONIST | ChEMBL |
| ACAMPROSATE | CHEMBL1201293 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ADIPIPLON | CHEMBL2103791 | GABA-A receptor; anion channel partial agonist | PARTIAL AGONIST | ChEMBL |
| ALPRAZOLAM | CHEMBL661 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BREXANOLONE | CHEMBL207538 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL | CHEMBL449 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL SODIUM | CHEMBL1200982 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTALBITAL | CHEMBL454 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 77
See all 77 drugsTrials1,186
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07602400 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07602400 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07584902 | CIPEPOFOL | ClinicalTrials.gov | ||
| NCT07584902 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07569198 | MIDAZOLAM | PHASE2 | ClinicalTrials.gov | |
| NCT07568938 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07560878 | LORAZEPAM | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07532733 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07513870 | SEVOFLURANE | ClinicalTrials.gov |
1 to 10 of 1,186
See all 1,186 trialsNIH grants507
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABRD papers | Newest fiscal year |
|---|---|---|---|
| P50AA022538 | Center for Alcohol Research in Epigenetics | 4 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 3 | 2025 |
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 3 | 2025 |
| R01AA012404 | Gene Expression in the Human Alcoholic Brain | 2 | 2025 |
| R01CA241137 | A microengineered colon cancer-chip designed to investigate tumor-stromal interactions driving cancer progression | 2 | 2025 |
| R01NS102937 | CRH Dysregulation of Brainstem Autonomic Circuits Increases SUDEP Risk | 2 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 2 | 2025 |
| U01AA020926 | 2/11 Spatially Resolved, Single Cell, Neuroimmune Transcriptomes in Alcohol Dependence | 2 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 2 | 2025 |
| ZIAES043012 | Genetics and Environment in Adult Respiratory, Allergic and Cardiac disease | 2 | 2025 |
1 to 10 of 507Source NIH's project files
See all 507 nih grantsPapers533
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| GABRD promotes hepatocellular carcinoma progression via the IL-10RA/JAK2-STAT3 signaling axis. | Cell Death Dis | 2026 | 42259775 | PubTator, text mining | PubMed |
Establishing the role of the neurotransmitter receptor-related gene GABRD in the diagnosis, prognosis and immune infiltrates of colorectal cancer by bioinformatics analysis and experimental validation. | Transl Cancer Res | 2026 | 42180912 | PubTator, text mining | PubMed |
| Epigenetic regulators polyphenols in neurodegenerative diseases: a promising intervention strategy. | Ann Med | 2026 | 41918250 | PubTator, text mining | PubMed |
| GABRD as an Emerging Oncogene: Exploring Functions and Therapeutic Implications Across Cancers. | Life (Basel) | 2026 | 41900986 | PubTator, text mining | PubMed |
| Changes in Blood DNA CpG Methylation Levels in Response to Methadone Maintenance Treatment: Epigenome-Wide Longitudinal Study. | Epigenomes | 2026 | 41892367 | PubTator, text mining | PubMed |
| Potential Biological Processes Related to Brain SLC13A5 Across the Lifespan: Weighted Gene Co-Expression Network Analysis from Large Human Transcriptomic Data. | Brain Sci | 2026 | 41750164 | PubTator, text mining | PubMed |
| Comprehensive Clinical, Diagnostic, and In Silico Assessment of a Novel 1p36.33p36.32 Copy Number Variant. | J Cell Mol Med | 2026 | 41738692 | PubTator, text mining | PubMed |
| Genetic-Epigenetic Interplay in Epilepsy: Pathways, Biomarkers, and Epigenome-Targeted Therapies. | Epigenomes | 2026 | 41718408 | PubTator, text mining | PubMed |
| First Detection of 1p36 Deletion by Whole-Exome Sequencing in a Tunisian Patient. | Birth Defects Res | 2026 | 41556146 | PubTator, text mining | PubMed |
| Peripheral cyclical expression of GABA-A receptor subunit genes and menstrual cycle affective change: a dimensional, transdiagnostic study. | Transl Psychiatry | 2025 | 41422264 | PubTator, text mining | PubMed |
1 to 10 of 533
See all 533 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2563
GET https://conductscience.org/api/genes/v1/2563/patents?page=2