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Gene · 2563

GABRD: gamma-aminobutyric acid type A receptor subunit delta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRD: gamma-aminobutyric acid type A receptor subunit delta. Genes, record 2563. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2563

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Gene

Symbol
GABRD
HGNC
Name
gamma-aminobutyric acid type A receptor subunit delta
HGNC
NCBI Gene ID
2563
NCBI Gene
HGNC ID
HGNC:4084
HGNC
Ensembl
ENSG00000187730
NCBI Gene
Aliases
EIG10, EJM7, GABAARdelta, GEFSP5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14764Gamma-aminobutyric acid receptor subunit delta4527Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447262O14764Espacenet
EP 4650780 A22025-11-1910060O14764Espacenet
EP 4641201 A22025-10-2910340O14764Espacenet
JP 2025529142 A2025-09-041661O14764Espacenet
JP 2025529142 A2025-09-046441O14764Espacenet
US 12371689 B22025-07-291661O14764Espacenet
US 12371689 B22025-07-296441O14764Espacenet
JP 2025517969 A2025-06-1210340O14764Espacenet
JP 2025517970 A2025-06-1210060O14764Espacenet
EP 4551941 A22025-05-1410O14764Espacenet

1 to 10 of 28

See all 28 patents

Drugs77

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITAL SODIUMCHEMBL1200982GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTALBITALCHEMBL454GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CENOBAMATECHEMBL3989949GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 77

See all 77 drugs

Trials1,186

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants507

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRD papersNewest fiscal year
P50AA022538Center for Alcohol Research in Epigenetics42025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).32025
R01AA012404Gene Expression in the Human Alcoholic Brain22025
R01CA241137A microengineered colon cancer-chip designed to investigate tumor-stromal interactions driving cancer progression22025
R01NS102937CRH Dysregulation of Brainstem Autonomic Circuits Increases SUDEP Risk22025
R28AA012725Brain Tissue Resource Center for Alcohol Research22025
U01AA0209262/11 Spatially Resolved, Single Cell, Neuroimmune Transcriptomes in Alcohol Dependence22025
ZIAAA000301Integrative genetics of behavior with high throughput technologies22025
ZIAES043012Genetics and Environment in Adult Respiratory, Allergic and Cardiac disease22025

1 to 10 of 507Source NIH's project files

See all 507 nih grants

Papers533

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
GABRD promotes hepatocellular carcinoma progression via the IL-10RA/JAK2-STAT3 signaling axis.Cell Death Dis202642259775PubTator, text miningPubMed
Establishing the role of the neurotransmitter receptor-related gene GABRD in the diagnosis, prognosis and immune infiltrates of colorectal cancer by bioinformatics analysis and experimental validation.
Transl Cancer Res202642180912PubTator, text miningPubMed
Epigenetic regulators polyphenols in neurodegenerative diseases: a promising intervention strategy.Ann Med202641918250PubTator, text miningPubMed
GABRD as an Emerging Oncogene: Exploring Functions and Therapeutic Implications Across Cancers.Life (Basel)202641900986PubTator, text miningPubMed
Changes in Blood DNA CpG Methylation Levels in Response to Methadone Maintenance Treatment: Epigenome-Wide Longitudinal Study.Epigenomes202641892367PubTator, text miningPubMed
Potential Biological Processes Related to Brain SLC13A5 Across the Lifespan: Weighted Gene Co-Expression Network Analysis from Large Human Transcriptomic Data.Brain Sci202641750164PubTator, text miningPubMed
Comprehensive Clinical, Diagnostic, and In Silico Assessment of a Novel 1p36.33p36.32 Copy Number Variant.J Cell Mol Med202641738692PubTator, text miningPubMed
Genetic-Epigenetic Interplay in Epilepsy: Pathways, Biomarkers, and Epigenome-Targeted Therapies.Epigenomes202641718408PubTator, text miningPubMed
First Detection of 1p36 Deletion by Whole-Exome Sequencing in a Tunisian Patient.Birth Defects Res202641556146PubTator, text miningPubMed
Peripheral cyclical expression of GABA-A receptor subunit genes and menstrual cycle affective change: a dimensional, transdiagnostic study.Transl Psychiatry202541422264PubTator, text miningPubMed

1 to 10 of 533

See all 533 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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