Gene · 2564
GABRE: gamma-aminobutyric acid type A receptor subunit epsilon
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABRE: gamma-aminobutyric acid type A receptor subunit epsilon. Genes, record 2564. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2564
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | 506 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47263 | P78334 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8763 | P78334 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8956 | P78334 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1662 | P78334 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1662 | P78334 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8956 | P78334 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8763 | P78334 | Espacenet |
| EP 4551941 A2 | 2025-05-14 | 11 | P78334 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 33941 | P78334 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3178 | P78334 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs76
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABP-700 | CHEMBL4297255 | GABA-A receptor; anion channel agonist | AGONIST | ChEMBL |
| ACAMPROSATE | CHEMBL1201293 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ADIPIPLON | CHEMBL2103791 | GABA-A receptor; anion channel partial agonist | PARTIAL AGONIST | ChEMBL |
| ALPRAZOLAM | CHEMBL661 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BREXANOLONE | CHEMBL207538 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL | CHEMBL449 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL SODIUM | CHEMBL1200982 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTALBITAL | CHEMBL454 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 76
See all 76 drugsTrials1,164
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07602400 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07602400 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07584902 | CIPEPOFOL | ClinicalTrials.gov | ||
| NCT07584902 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07569198 | MIDAZOLAM | PHASE2 | ClinicalTrials.gov | |
| NCT07568938 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07560878 | LORAZEPAM | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07532733 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07513870 | SEVOFLURANE | ClinicalTrials.gov |
1 to 10 of 1,164
See all 1,164 trialsNIH grants315
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABRE papers | Newest fiscal year |
|---|---|---|---|
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 3 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 2 | 2025 |
| P50CA136393 | Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer | 2 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 2 | 2025 |
| DP1DA054344 | X chromosome inactivation in sex disparities to substance use disorder | 1 | 2025 |
| K24AG053435 | Neuropathological changes underlying clinical heterogeneity in Alzheimer disease | 1 | 2025 |
| KL2TR001862 | Institutional Career Development Core | 1 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 1 | 2025 |
| P01CA163227 | Androgen Receptor Action in Castration Resistant Prostate Cancer | 1 | 2025 |
| P01DA047233 | Transcriptional Mechanisms of Drug Addiction | 1 | 2025 |
1 to 10 of 315Source NIH's project files
See all 315 nih grantsPapers352
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Sodium Overload-Related Molecular Subtypes and a Four-Gene Prognostic Signature Predict Survival, Immune Landscape, and Therapeutic Response in Acute Myeloid Leukemia. | Mol Carcinog | 2026 | 42541488 | PubTator, text mining | PubMed |
| Identification of a prognostic signature based on expression of post-translational modification-related genes in acute myeloid leukemia. | Jpn J Clin Oncol | 2026 | 42490412 | PubTator, text mining | PubMed |
| Platelet-Related Gene Signature Predicts Prognosis, Immune Landscape, and Drug Sensitivity in Acute Myeloid Leukemia. | Biofactors | 2026 | 42340073 | PubTator, text mining | PubMed |
| Selective inhibition of ALDH1A3 impedes breast cancer growth and metastasis by blocking ALDH1A3-driven transcriptional programs. | iScience | 2026 | 41797928 | PubTator, text mining | PubMed |
| Context-dependent features of transcriptomic landscapes in pregnant mother-neonate dyads of preeclampsia. | Clin Exp Pediatr | 2026 | 41713209 | PubTator, text mining | PubMed |
| Integrating Network Analysis and Machine Learning Identifies Key Autism Spectrum Disorder Genes Linked to Immune Dysregulation and Therapeutic Targets. | Genes (Basel) | 2025 | 41010054 | PubTator, text mining | PubMed |
| Identification of a 13-Gene Immune Signature in Liver Fibrosis Reveals GABRE as a Novel Candidate Biomarker. | Int J Mol Sci | 2025 | 40943308 | PubTator, text mining | PubMed |
| Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics. | Nat Commun | 2025 | 40835596 | PubTator, text mining | PubMed |
| Towards a precision approach to anesthetic/analgesic immunomodulation in cancer. | Front Anesthesiol | 2024 | 40909996 | PubTator, text mining | PubMed |
| Cognitive dysfunction in schizophrenia patients caused by down-regulation of γ-aminobutyric acid receptor subunits. | World J Psychiatry | 2024 | 38984326 | PubTator, text mining | PubMed |
1 to 10 of 352
See all 352 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2564
GET https://conductscience.org/api/genes/v1/2564/patents?page=2