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Gene · 2564

GABRE: gamma-aminobutyric acid type A receptor subunit epsilon

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRE: gamma-aminobutyric acid type A receptor subunit epsilon. Genes, record 2564. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2564

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Gene

Symbol
GABRE
HGNC
Name
gamma-aminobutyric acid type A receptor subunit epsilon
HGNC
NCBI Gene ID
2564
NCBI Gene
HGNC ID
HGNC:4085
HGNC
Ensembl
ENSG00000102287
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P78334Gamma-aminobutyric acid receptor subunit epsilon5060Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447263P78334Espacenet
EP 4650780 A22025-11-198763P78334Espacenet
EP 4641201 A22025-10-298956P78334Espacenet
JP 2025529142 A2025-09-041662P78334Espacenet
US 12371689 B22025-07-291662P78334Espacenet
JP 2025517969 A2025-06-128956P78334Espacenet
JP 2025517970 A2025-06-128763P78334Espacenet
EP 4551941 A22025-05-1411P78334Espacenet
US 11446398 B22022-09-2033941P78334Espacenet
US 11400116 B22022-08-023178P78334Espacenet

1 to 10 of 23

See all 23 patents

Drugs76

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITAL SODIUMCHEMBL1200982GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTALBITALCHEMBL454GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CENOBAMATECHEMBL3989949GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 76

See all 76 drugs

Trials1,164

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants315

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRE papersNewest fiscal year
ZIAAA000301Integrative genetics of behavior with high throughput technologies32025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant22025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer22025
UL1TR001863Yale Clinical and Translational Science Award22025
DP1DA054344X chromosome inactivation in sex disparities to substance use disorder12025
K24AG053435Neuropathological changes underlying clinical heterogeneity in Alzheimer disease12025
KL2TR001862Institutional Career Development Core12025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions12025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer12025
P01DA047233Transcriptional Mechanisms of Drug Addiction12025

1 to 10 of 315Source NIH's project files

See all 315 nih grants

Papers352

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Sodium Overload-Related Molecular Subtypes and a Four-Gene Prognostic Signature Predict Survival, Immune Landscape, and Therapeutic Response in Acute Myeloid Leukemia.Mol Carcinog202642541488PubTator, text miningPubMed
Identification of a prognostic signature based on expression of post-translational modification-related genes in acute myeloid leukemia.Jpn J Clin Oncol202642490412PubTator, text miningPubMed
Platelet-Related Gene Signature Predicts Prognosis, Immune Landscape, and Drug Sensitivity in Acute Myeloid Leukemia.Biofactors202642340073PubTator, text miningPubMed
Selective inhibition of ALDH1A3 impedes breast cancer growth and metastasis by blocking ALDH1A3-driven transcriptional programs.iScience202641797928PubTator, text miningPubMed
Context-dependent features of transcriptomic landscapes in pregnant mother-neonate dyads of preeclampsia.Clin Exp Pediatr202641713209PubTator, text miningPubMed
Integrating Network Analysis and Machine Learning Identifies Key Autism Spectrum Disorder Genes Linked to Immune Dysregulation and Therapeutic Targets.Genes (Basel)202541010054PubTator, text miningPubMed
Identification of a 13-Gene Immune Signature in Liver Fibrosis Reveals GABRE as a Novel Candidate Biomarker.Int J Mol Sci202540943308PubTator, text miningPubMed
Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics.Nat Commun202540835596PubTator, text miningPubMed
Towards a precision approach to anesthetic/analgesic immunomodulation in cancer.Front Anesthesiol202440909996PubTator, text miningPubMed
Cognitive dysfunction in schizophrenia patients caused by down-regulation of γ-aminobutyric acid receptor subunits.World J Psychiatry202438984326PubTator, text miningPubMed

1 to 10 of 352

See all 352 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2564

GET https://conductscience.org/api/genes/v1/2564/patents?page=2