Gene · 2565
GABRG1: gamma-aminobutyric acid type A receptor subunit gamma1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABRG1: gamma-aminobutyric acid type A receptor subunit gamma1. Genes, record 2565. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2565
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | 465 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47265 | Q8N1C3 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3616 | Q8N1C3 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3212 | Q8N1C3 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1663 | Q8N1C3 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1663 | Q8N1C3 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3212 | Q8N1C3 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3616 | Q8N1C3 | Espacenet |
| EP 4551941 A2 | 2025-05-14 | 12 | Q8N1C3 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 33944 | Q8N1C3 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 6354 | Q8N1C3 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs76
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABP-700 | CHEMBL4297255 | GABA-A receptor; anion channel agonist | AGONIST | ChEMBL |
| ACAMPROSATE | CHEMBL1201293 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ADIPIPLON | CHEMBL2103791 | GABA-A receptor; anion channel partial agonist | PARTIAL AGONIST | ChEMBL |
| ALPRAZOLAM | CHEMBL661 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BREXANOLONE | CHEMBL207538 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL | CHEMBL449 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL SODIUM | CHEMBL1200982 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTALBITAL | CHEMBL454 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 76
See all 76 drugsTrials1,164
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07602400 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07602400 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07584902 | CIPEPOFOL | ClinicalTrials.gov | ||
| NCT07584902 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07569198 | MIDAZOLAM | PHASE2 | ClinicalTrials.gov | |
| NCT07568938 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07560878 | LORAZEPAM | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07532733 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07513870 | SEVOFLURANE | ClinicalTrials.gov |
1 to 10 of 1,164
See all 1,164 trialsNIH grants658
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABRG1 papers | Newest fiscal year |
|---|---|---|---|
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 20 | 2025 |
| P60AA007611 | Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol | 5 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 5 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 5 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 3 | 2025 |
| P60AA006420 | CNS Effects of Alcohol: Cellular Neurobiology | 3 | 2025 |
| P30ES019776 | HERCULES: Exposome Research Center | 2 | 2025 |
| P60AA010760 | Behavioral Genomics of Alcohol Neuroadaptation | 2 | 2025 |
| R01AA012404 | Gene Expression in the Human Alcoholic Brain | 2 | 2025 |
| R25MH077823 | Research Education for Future Physician-Scientists in Child Psychiatry | 2 | 2025 |
1 to 10 of 658Source NIH's project files
See all 658 nih grantsPapers347
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrated bulk and single-cell RNA sequencing reveals a prognostic neuro-mimicry signature in papillary thyroid carcinoma. | Discov Oncol | 2026 | 42329337 | PubTator, text mining | PubMed |
| Loss of SALL1 Promotes Hepatocellular Carcinoma Growth and Is Associated with Poor Clinical Outcome. | Cancers (Basel) | 2026 | 42122151 | PubTator, text mining | PubMed |
| Multi-omics and electrophysiological examination of GABAA receptors in the dorsolateral prefrontal cortex of humans with alcohol use disorder. | Mol Psychiatry | 2026 | 41965895 | PubTator, text mining | PubMed |
| Integrated Clinical Genetic Analysis Reveals Transcriptional Neurotransmitter Receptor Dysregulation in Meningiomas Causing Seizure. | Neurosurgery | 2026 | 41677355 | PubTator, text mining | PubMed |
| Neuro-related gene signatures predict prognosis in diffuse large B-Cell lymphoma and uncover TRPV2-mediated tumor microenvironment regulation. | Ann Hematol | 2026 | 41549103 | PubTator, text mining | PubMed |
| Decoding the pituitary response to photoperiod in geese: Central role in regulating reproduction. | Theriogenology | 2026 | 41420901 | PubTator, text mining | PubMed |
| NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors. | Elife | 2025 | 40875449 | PubTator, text mining | PubMed |
| Differential Expression of GABA Receptor-Related Genes in Alzheimer's Disease and the Positive Regulatory Role of Aerobic Exercise-From Genetic Screening to D-gal-induced AD-like Pathology Model. | Neuromolecular Med | 2024 | 39752101 | PubTator, text mining | PubMed |
| Huanglian Jiedu decoction alleviates ischemia-induced cerebral injury in rats by mitigating NET formation and activiting GABAergic synapses. | J Cell Mol Med | 2024 | 39099086 | PubTator, text mining | PubMed |
| Gene Expression of GABAA Receptor Subunits and Association with Patient Survival in Glioma. | Brain Sci | 2024 | 38539663 | PubTator, text mining | PubMed |
1 to 10 of 347
See all 347 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2565
GET https://conductscience.org/api/genes/v1/2565/patents?page=2