Gene · 2566
GABRG2: gamma-aminobutyric acid type A receptor subunit gamma2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABRG2: gamma-aminobutyric acid type A receptor subunit gamma2. Genes, record 2566. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2566
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | 475 | 77 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47267 | P18507 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 24411 | P18507 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 24411 | P18507 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 28777 | P18507 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 28777 | P18507 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 28777 | P18507 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 33945 | P18507 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 6843 | P18507 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 136916 | P18507 | Espacenet |
| JP 2020508652 A | 2020-03-26 | 28777 | P18507 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs79
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABP-700 | CHEMBL4297255 | GABA-A receptor; anion channel agonist | AGONIST | ChEMBL |
| ACAMPROSATE | CHEMBL1201293 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | GABA-A receptor; anion channel positive modulator | POSITIVE MODULATOR | ChEMBL |
| ADIPIPLON | CHEMBL2103791 | GABA-A receptor; anion channel partial agonist | PARTIAL AGONIST | ChEMBL |
| ALPRAZOLAM | CHEMBL661 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BREXANOLONE | CHEMBL207538 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL | CHEMBL449 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTABARBITAL SODIUM | CHEMBL1200982 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| BUTALBITAL | CHEMBL454 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 79
See all 79 drugsTrials1,230
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07602400 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07602400 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07584902 | CIPEPOFOL | ClinicalTrials.gov | ||
| NCT07584902 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07569198 | MIDAZOLAM | PHASE2 | ClinicalTrials.gov | |
| NCT07568938 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07560878 | LORAZEPAM | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07532733 | PROPOFOL | ClinicalTrials.gov | ||
| NCT07513870 | SEVOFLURANE | ClinicalTrials.gov |
1 to 10 of 1,230
See all 1,230 trialsNIH grants1,121
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABRG2 papers | Newest fiscal year |
|---|---|---|---|
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 8 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 6 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 5 | 2025 |
| P30EY008126 | Core Grant in Vision Research | 4 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 4 | 2025 |
| P50HD103537 | Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt | 4 | 2025 |
| R01AA012404 | Gene Expression in the Human Alcoholic Brain | 4 | 2025 |
| R01NS105789 | Understanding GABAA receptor protein folding and misfolding | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,121Source NIH's project files
See all 1,121 nih grantsPapers1,344
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Accurate prediction of gain- and loss-of-function missense variants in GABAA receptors. | EBioMedicine | 2026 | 42546502 | PubTator, text mining | PubMed |
| Exon-level GABRG2 deletion in familial generalized epilepsy with febrile seizures plus: A clinical vignette. | Epileptic Disord | 2026 | 42473914 | PubTator, text mining | PubMed |
| Integrated bulk and single-cell RNA sequencing reveals a prognostic neuro-mimicry signature in papillary thyroid carcinoma. | Discov Oncol | 2026 | 42329337 | PubTator, text mining | PubMed |
| Phenotype and genotype of people with epilepsy and GABAA receptor gene variants: Genetic and clinical characterization of six children in China. | Epilepsy Res | 2026 | 42250373 | PubTator, text mining | PubMed |
| Gene burden meta-analysis of 748 879 individuals identifies LGI1-ADAM23 protein complex association with epilepsy. | Epilepsia | 2026 | 42216960 | PubTator, text mining | PubMed |
| Integrated network toxicology and computational profiling of acetyl tributyl citrate-related mechanisms in Alzheimer's disease. | J Alzheimers Dis | 2026 | 41823681 | PubTator, text mining | PubMed |
| Retraction Note: Insight into molecular and mutational scrutiny of epilepsy associated gene Gabrg2 leading to novel computer-aided drug designing. | Sci Rep | 2026 | 41796192 | PubTator, text mining | PubMed |
| A SCN1A missense variant (c.4522T>A, p.(Tyr1508Asn) associated with genetic epilepsy with febrile seizures plus: clinical phenotype and genetic analysis of a Chinese pedigree. | Front Genet | 2026 | 41788412 | PubTator, text mining | PubMed |
| Comparative cross-methodological analysis of the IDH-wildtype glioblastoma tumor microenvironment. | J Cancer Res Clin Oncol | 2026 | 41762316 | PubTator, text mining | PubMed |
| Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex. | bioRxiv | 2026 | 41757081 | PubTator, text mining | PubMed |
1 to 10 of 1,344
See all 1,344 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2566
GET https://conductscience.org/api/genes/v1/2566/patents?page=2