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Gene · 2566

GABRG2: gamma-aminobutyric acid type A receptor subunit gamma2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABRG2: gamma-aminobutyric acid type A receptor subunit gamma2. Genes, record 2566. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2566

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Gene

Symbol
GABRG2
HGNC
Name
gamma-aminobutyric acid type A receptor subunit gamma2
HGNC
NCBI Gene ID
2566
NCBI Gene
HGNC ID
HGNC:4087
HGNC
Ensembl
ENSG00000113327
NCBI Gene
Aliases
CAE2, DEE74, ECA2, EIEE74, FEB8, GEFSP3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18507Gamma-aminobutyric acid receptor subunit gamma-247577Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447267P18507Espacenet
EP 4641201 A22025-10-2924411P18507Espacenet
JP 2025517969 A2025-06-1224411P18507Espacenet
JP 2025032204 A2025-03-1128777P18507Espacenet
EP 4461818 A22024-11-1328777P18507Espacenet
JP 2023058610 A2023-04-2528777P18507Espacenet
US 11446398 B22022-09-2033945P18507Espacenet
US 11400116 B22022-08-026843P18507Espacenet
JP 2022524081 A2022-04-27136916P18507Espacenet
JP 2020508652 A2020-03-2628777P18507Espacenet

1 to 10 of 22

See all 22 patents

Drugs79

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABP-700CHEMBL4297255GABA-A receptor; anion channel agonistAGONISTChEMBL
ACAMPROSATECHEMBL1201293GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724GABA-A receptor; anion channel positive modulatorPOSITIVE MODULATORChEMBL
ADIPIPLONCHEMBL2103791GABA-A receptor; anion channel partial agonistPARTIAL AGONISTChEMBL
ALPRAZOLAMCHEMBL661GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BREXANOLONECHEMBL207538GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITALCHEMBL449GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTABARBITAL SODIUMCHEMBL1200982GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
BUTALBITALCHEMBL454GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CENOBAMATECHEMBL3989949GABA-A receptor; anion channel positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 79

See all 79 drugs

Trials1,230

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,121

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABRG2 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).82025
ZIAAA000301Integrative genetics of behavior with high throughput technologies62025
R28AA012725Brain Tissue Resource Center for Alcohol Research52025
P30EY008126Core Grant in Vision Research42025
P50AA012870Center for the Translational Neuroscience of Alcoholism42025
P50HD103537Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt42025
R01AA012404Gene Expression in the Human Alcoholic Brain42025
R01NS105789Understanding GABAA receptor protein folding and misfolding42025
P30CA008748Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025

1 to 10 of 1,121Source NIH's project files

See all 1,121 nih grants

Papers1,344

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Accurate prediction of gain- and loss-of-function missense variants in GABAA receptors.EBioMedicine202642546502PubTator, text miningPubMed
Exon-level GABRG2 deletion in familial generalized epilepsy with febrile seizures plus: A clinical vignette.Epileptic Disord202642473914PubTator, text miningPubMed
Integrated bulk and single-cell RNA sequencing reveals a prognostic neuro-mimicry signature in papillary thyroid carcinoma.Discov Oncol202642329337PubTator, text miningPubMed
Phenotype and genotype of people with epilepsy and GABAA receptor gene variants: Genetic and clinical characterization of six children in China.Epilepsy Res202642250373PubTator, text miningPubMed
Gene burden meta-analysis of 748 879 individuals identifies LGI1-ADAM23 protein complex association with epilepsy.Epilepsia202642216960PubTator, text miningPubMed
Integrated network toxicology and computational profiling of acetyl tributyl citrate-related mechanisms in Alzheimer's disease.J Alzheimers Dis202641823681PubTator, text miningPubMed
Retraction Note: Insight into molecular and mutational scrutiny of epilepsy associated gene Gabrg2 leading to novel computer-aided drug designing.Sci Rep202641796192PubTator, text miningPubMed
A SCN1A missense variant (c.4522T>A, p.(Tyr1508Asn) associated with genetic epilepsy with febrile seizures plus: clinical phenotype and genetic analysis of a Chinese pedigree.Front Genet202641788412PubTator, text miningPubMed
Comparative cross-methodological analysis of the IDH-wildtype glioblastoma tumor microenvironment.J Cancer Res Clin Oncol202641762316PubTator, text miningPubMed
Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex.bioRxiv202641757081PubTator, text miningPubMed

1 to 10 of 1,344

See all 1,344 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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