Gene · 2581
GALC: galactosylceramidase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GALC: galactosylceramidase. Genes, record 2581. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2581
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P54803 | Galactocerebrosidase | 685 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents87
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 269 | P54803 | Espacenet |
| US 12570963 B2 | 2026-03-10 | 33 | P54803 | Espacenet |
| EP 4695389 A2 | 2026-02-18 | 1 | P54803 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47205 | P54803 | Espacenet |
| US 12516298 B2 | 2026-01-06 | 33 | P54803 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1870 | P54803 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4516 | P54803 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5737 | P54803 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1670 | P54803 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6448 | P54803 | Espacenet |
1 to 10 of 87
See all 87 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,225
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GALC papers | Newest fiscal year |
|---|---|---|---|
| R01DK067859 | Development of Assays for Newborn Screening and for Post-Screening Evaluation of Disease Severity | 18 | 2025 |
| P01CA097132 | Sphingolipids in Cancer Biology and Therapy | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| R01NS112327 | Selective galactosylceramidase ablation to study the pathogenesis of Krabbe leukodystrophy | 5 | 2025 |
| P51OD011104 | Tulane National Primate Research Center | 4 | 2025 |
| R01MH098742 | Oligodendrocyte damage and dysfunction in HIV associated neurocognitive disorder | 4 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 3 | 2025 |
| P30AG066509 | University of Washington Alzheimer's Disease Research Center | 3 | 2025 |
| P30DK020579 | Diabetes Research Center | 3 | 2025 |
| P30EY005722 | Center Core Grant for Vision Research | 3 | 2025 |
1 to 10 of 1,225Source NIH's project files
See all 1,225 nih grantsPapers1,700
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Dysregulation of Sphingolipid Metabolism in Non-Obstructive Azoospermia: Insights from Bioinformatics and a Busulfan-Induced Mouse Model. | Reprod Sci | 2026 | 42722974 | PubTator, text mining | PubMed |
| Pedigree Case Report of adult-onset phenotypically heterogeneous Krabbe disease. | Front Genet | 2026 | 42703459 | PubTator, text mining | PubMed |
| Homozygosity for a Clinically Significant GALC Haplotype Associated with Late-Infantile Krabbe Disease Detected on Newborn Screening: Implications for Clinical Management and Genetic Counseling. | Int J Neonatal Screen | 2026 | 42647246 | PubTator, text mining | PubMed |
| Globoid cell leukodystrophy (Krabbe disease). | Ideggyogy Sz | 2026 | 42554324 | PubTator, text mining | PubMed |
| Neonatal genetic sequencing as a first-tier option: a real-world clinical implementation study in Northern China. | Ann Med | 2026 | 42422968 | PubTator, text mining | PubMed |
| Sex-biased Genetic Risk Loci and Causal Brain Proteins in Parkinson's Disease. | medRxiv | 2026 | 42396329 | PubTator, text mining | PubMed |
| Pediatric hereditary optic neuropathies in the United Arab Emirates. | Ophthalmic Genet | 2026 | 42299460 | PubTator, text mining | PubMed |
| First reported case of Turner syndrome with Krabbe disease in a child: a case report. | Transl Pediatr | 2026 | 42292618 | PubTator, text mining | PubMed |
| Validating a Human Cell Model of Null Galactosylceramidase (GALC) Enzyme Activity That Recapitulates Krabbe Disease. | J Inherit Metab Dis | 2026 | 42271546 | PubTator, text mining | PubMed |
| Molecular Dynamics Simulations of 4 GALC Variants Causing Krabbe Disease. | Comput Struct Biotechnol J | 2026 | 42169729 | PubTator, text mining | PubMed |
1 to 10 of 1,700
See all 1,700 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2581
GET https://conductscience.org/api/genes/v1/2581/patents?page=2