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Gene · 25828

TXN2: thioredoxin 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TXN2: thioredoxin 2. Genes, record 25828. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/25828

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Gene

Symbol
TXN2
HGNC
Name
thioredoxin 2
HGNC
NCBI Gene ID
25828
NCBI Gene
HGNC ID
HGNC:17772
HGNC
Ensembl
ENSG00000100348
NCBI Gene
Aliases
COXPD29, MT-TRX, MTRX, TRX2, TXN
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99757Thioredoxin, mitochondrial1663Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19315Q99757Espacenet
EP 4641202 A22025-10-294314Q99757Espacenet
JP 2025517970 A2025-06-12315Q99757Espacenet
KR 1020250017231 A2025-02-044314Q99757Espacenet
US 11446398 B22022-09-2088353Q99757Espacenet
US 11446398 B22022-09-2088354Q99757Espacenet
JP 2022524081 A2022-04-27191324Q99757Espacenet
JP 2022524081 A2022-04-27191325Q99757Espacenet
WO 2020043864 A12020-03-052593Q99757Espacenet
JP 2017121240 A2017-07-1354890Q99757Espacenet

1 to 10 of 20

See all 20 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants919

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTXN2 papersNewest fiscal year
P30ES019776HERCULES: Exposome Research Center62025
P30CA012197Cancer Center Support Grant52025
P30EY004068Core Grant for Vision Research52025
T32ES012870Graduate and Postdoctoral Training in Environmental Health Science and Toxicology52025
P30DK058404Molecular and Cellular Basis for Digestive Diseases42025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer32025
R01HL091469Cysteine oxidation in the heart32025
P30AG013319San Antonio Nathan Shock Center of Excellence in the Biology of Aging22025
P30AG021332Wake Forest Claude D. Pepper OAIC - Renewal22025
P30AG024827Pittsburgh Older Americans Independence Center22025

1 to 10 of 919Source NIH's project files

See all 919 nih grants

Papers1,287

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of Endonuclease G binding protein using a method which specifically isolates binding partners within subcellular compartments.Mol Cell Proteomics202642815854PubTator, text miningPubMed
Muscularis EGR1 Deficiency Impairs M2 Macrophage Polarization and Disrupts Gastric Motility in Diabetic Gastroparesis.Neurogastroenterol Motil202642745198PubTator, text miningPubMed
Long-read sequencing reveals widespread novel splicing and neojunction-derived neoantigens in nasopharyngeal carcinoma.Genome Res202642680560PubTator, text miningPubMed
Sodium selenite attenuates sepsis-induced cardiac inflammation and oxidative injury by regulating TXN2/TXNIP/NLRP3 signaling and ferroptosis.Front Pharmacol202642460027PubTator, text miningPubMed
Regulation of the endoplasmic reticulum stress sensor ATF6α through multiple oxidoreductases in the ER.iScience202642305590PubTator, text miningPubMed
The integrated analysis of PRDX3 in lung cancer: biomarker potential and therapeutic target prospects.Respir Res202642092925PubTator, text miningPubMed
CITED2: a novel hub gene downregulated in Hashimoto's thyroiditis and associated with M1 macrophages via bioinformatics analysis and clinical validation.Front Immunol202641822519PubTator, text miningPubMed
Low salivary thioredoxin-1 levels in periodontitis.World J Clin Cases202641810051PubTator, text miningPubMed
ALDH1L2 induces resistance to chemotherapy in small cell lung cancer by inhibiting ferroptosis.Redox Biol202641764940PubTator, text miningPubMed
FGF-FGFR Signaling in Parkinson's Disease: Mechanistic Links to Ferroptosis and Neuroprotection.Brain Sci202641750151PubTator, text miningPubMed

1 to 10 of 1,287

See all 1,287 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/25828

GET https://conductscience.org/api/genes/v1/25828/patents