Gene · 25828
TXN2: thioredoxin 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TXN2: thioredoxin 2. Genes, record 25828. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/25828
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99757 | Thioredoxin, mitochondrial | 166 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents20
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 315 | Q99757 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4314 | Q99757 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 315 | Q99757 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4314 | Q99757 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 88353 | Q99757 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 88354 | Q99757 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 191324 | Q99757 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 191325 | Q99757 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 2593 | Q99757 | Espacenet |
| JP 2017121240 A | 2017-07-13 | 54890 | Q99757 | Espacenet |
1 to 10 of 20
See all 20 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants919
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TXN2 papers | Newest fiscal year |
|---|---|---|---|
| P30ES019776 | HERCULES: Exposome Research Center | 6 | 2025 |
| P30CA012197 | Cancer Center Support Grant | 5 | 2025 |
| P30EY004068 | Core Grant for Vision Research | 5 | 2025 |
| T32ES012870 | Graduate and Postdoctoral Training in Environmental Health Science and Toxicology | 5 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 4 | 2025 |
| P01CA116087 | H. pylori-induced Inflammation and Gastric Cancer | 3 | 2025 |
| R01HL091469 | Cysteine oxidation in the heart | 3 | 2025 |
| P30AG013319 | San Antonio Nathan Shock Center of Excellence in the Biology of Aging | 2 | 2025 |
| P30AG021332 | Wake Forest Claude D. Pepper OAIC - Renewal | 2 | 2025 |
| P30AG024827 | Pittsburgh Older Americans Independence Center | 2 | 2025 |
1 to 10 of 919Source NIH's project files
See all 919 nih grantsPapers1,287
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of Endonuclease G binding protein using a method which specifically isolates binding partners within subcellular compartments. | Mol Cell Proteomics | 2026 | 42815854 | PubTator, text mining | PubMed |
| Muscularis EGR1 Deficiency Impairs M2 Macrophage Polarization and Disrupts Gastric Motility in Diabetic Gastroparesis. | Neurogastroenterol Motil | 2026 | 42745198 | PubTator, text mining | PubMed |
| Long-read sequencing reveals widespread novel splicing and neojunction-derived neoantigens in nasopharyngeal carcinoma. | Genome Res | 2026 | 42680560 | PubTator, text mining | PubMed |
| Sodium selenite attenuates sepsis-induced cardiac inflammation and oxidative injury by regulating TXN2/TXNIP/NLRP3 signaling and ferroptosis. | Front Pharmacol | 2026 | 42460027 | PubTator, text mining | PubMed |
| Regulation of the endoplasmic reticulum stress sensor ATF6α through multiple oxidoreductases in the ER. | iScience | 2026 | 42305590 | PubTator, text mining | PubMed |
| The integrated analysis of PRDX3 in lung cancer: biomarker potential and therapeutic target prospects. | Respir Res | 2026 | 42092925 | PubTator, text mining | PubMed |
| CITED2: a novel hub gene downregulated in Hashimoto's thyroiditis and associated with M1 macrophages via bioinformatics analysis and clinical validation. | Front Immunol | 2026 | 41822519 | PubTator, text mining | PubMed |
| Low salivary thioredoxin-1 levels in periodontitis. | World J Clin Cases | 2026 | 41810051 | PubTator, text mining | PubMed |
| ALDH1L2 induces resistance to chemotherapy in small cell lung cancer by inhibiting ferroptosis. | Redox Biol | 2026 | 41764940 | PubTator, text mining | PubMed |
| FGF-FGFR Signaling in Parkinson's Disease: Mechanistic Links to Ferroptosis and Neuroprotection. | Brain Sci | 2026 | 41750151 | PubTator, text mining | PubMed |
1 to 10 of 1,287
See all 1,287 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/25828
GET https://conductscience.org/api/genes/v1/25828/patents