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Gene · 25833

POU2F3: POU class 2 homeobox 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POU2F3: POU class 2 homeobox 3. Genes, record 25833. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/25833

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Gene

Symbol
POU2F3
HGNC
Name
POU class 2 homeobox 3
HGNC
NCBI Gene ID
25833
NCBI Gene
HGNC ID
HGNC:19864
HGNC
Ensembl
ENSG00000137709
NCBI Gene
Aliases
Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UKI9POU domain, class 2, transcription factor 34363Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458837Q9UKI9Espacenet
EP 4641201 A22025-10-2919724Q9UKI9Espacenet
JP 2025147176 A2025-10-0615505Q9UKI9Espacenet
JP 2025517969 A2025-06-1219724Q9UKI9Espacenet
JP 2025028160 A2025-02-2815505Q9UKI9Espacenet
KR 1020250010750 A2025-01-2115505Q9UKI9Espacenet
JP 2024109657 A2024-08-1415344Q9UKI9Espacenet
US 11446398 B22022-09-2065986Q9UKI9Espacenet
JP 2022524081 A2022-04-27168957Q9UKI9Espacenet
JP 2021536249 A2021-12-2715698Q9UKI9Espacenet

1 to 10 of 15

See all 15 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,084

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOU2F3 papersNewest fiscal year
U24CA213274Coordinating center for the NCI small cell lung cancer research consortium342025
P30CA008748Cancer Center Support Grant282025
R35CA263816Novel therapeutic development for small cell lung cancer122025
P30CA016672Cancer Center Support Grant112025
R01CA207295DNA damaging therapy and immune response in small cell lung cancer subtypes92025
R01AI109023Defining P. falciparum resistance to artemisinin-based combination therapies82025
R01AI124678Elucidating the molecular basis of piperaquine resistance in Plasmodium falciparum82025
R37AI050234Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug Resistance72025
P30CA068485Cancer Center Support Grant62025
ZIABC011793Exploiting DNA Replicative Stress for Novel Small Cell Lung Cancer Therapies52025

1 to 10 of 1,084Source NIH's project files

See all 1,084 nih grants

Papers1,618

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Plasma nucleosome profiling reports on tumor burden and molecular subtypes in small cell lung cancer.J Clin Invest202642820295PubTator, text miningPubMed
Adjunctive diagnostic utility of POU2F3 in predominantly pulmonary high-grade neuroendocrine carcinomas with limited or discordant conventional marker expression: a case-control study.Front Med (Lausanne)202642774020PubTator, text miningPubMed
Case Report: Neuroendocrine-low POU2F3-positive small cell lung cancer presenting as a diagnostically unstable thoracic malignancy.Front Oncol202642760987PubTator, text miningPubMed
Immunohistochemical stratification of bladder small cell carcinoma reveals two major phenotypes with distinct therapeutic biomarker profiles.Histopathology202642747234PubTator, text miningPubMed
OX40 (TNFRSF4) Tracks Immune Infiltration in Small Cell Lung Cancer and Shows a Cohort-Specific, Non-Replicated Association with the POU2F3/SCLC-P Subtype: A Multi-Source In Silico Analysis.Int J Mol Sci202642737720PubTator, text miningPubMed
Molecular Subtyping of Biliary Tract Neuroendocrine Carcinomas: Clinicopathological Features and Prognostic Implications.Am J Surg Pathol202642733321PubTator, text miningPubMed
[Expert Consensus on Immunotherapy for Extensive-stage Small Cell Lung Cancer Based on Molecular Subtyping].Zhongguo Fei Ai Za Zhi202642705850PubTator, text miningPubMed
Tuft cells contribute to the pathogenesis of human primary and experimental murine Sjögren's disease.J Dent Sci202642688877PubTator, text miningPubMed
Quantitative Immunohistochemical Landscapes and Chemoimmunotherapy Outcomes of ASCL1, NEUROD1, POU2F3, and YAP1 in Pure Small-Cell Lung Cancer: A Pilot Study.J Clin Med202642652818PubTator, text miningPubMed
Proteomic landscape of pan-tissue neuroendocrine carcinomas defines subtype-specific functional architectures, biomarkers and therapeutic targets.Gut202642648907PubTator, text miningPubMed

1 to 10 of 1,618

See all 1,618 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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