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Gene · 2588

GALNS: galactosamine (N-acetyl)-6-sulfatase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GALNS: galactosamine (N-acetyl)-6-sulfatase. Genes, record 2588. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2588

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Gene

Symbol
GALNS
HGNC
Name
galactosamine (N-acetyl)-6-sulfatase
HGNC
NCBI Gene ID
2588
NCBI Gene
HGNC ID
HGNC:4122
HGNC
Ensembl
ENSG00000141012
NCBI Gene
Aliases
GALNAC6S, GAS, GalN6S, MPS4A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P34059N-acetylgalactosamine-6-sulfatase5222Ensembl, GeneID, HGNC

Source UniProt

Patents89

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21270P34059Espacenet
EP 4650780 A22025-11-192674P34059Espacenet
JP 2025169942 A2025-11-14992P34059Espacenet
JP 2025147176 A2025-10-065748P34059Espacenet
JP 2025529142 A2025-09-046449P34059Espacenet
US 12371689 B22025-07-296449P34059Espacenet
JP 2025517970 A2025-06-122674P34059Espacenet
JP 2025028160 A2025-02-285748P34059Espacenet
KR 1020250010750 A2025-01-215748P34059Espacenet
US 12201095 B22025-01-212P34059Espacenet

1 to 10 of 89

See all 89 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,525

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGALNS papersNewest fiscal year
R01DK067859Development of Assays for Newborn Screening and for Post-Screening Evaluation of Disease Severity142025
R01HD102545Non-invasive functional assessment and pathogenesis of Morquio A92025
R01MH054137Structure and Function of Dopamine Receptors92025
P30CA016672Cancer Center Support Grant62025
P40OD010440Caenorhabditis Genetics Center62025
R01DA036596Regulation of Neuronal GPCR Signaling62025
R01GM122798Biasing CXCR3 Signaling to Modulate the Inflammatory Response62025
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors62025
R01HL056687Mechanisms of Maladaptation in Heart Failure62025
P30CA030199Cancer Center Support Grant (CCSG)52025

1 to 10 of 2,525Source NIH's project files

See all 2,525 nih grants

Papers3,532

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Molecular basis of mucopolysaccharidosis IVA in a large cohort: genotype-phenotype correlations and reporting of 12 novel GALNS variants.Hum Mol Genet202642822866PubTator, text miningPubMed
GALNS gene variants and clinical severity in pediatric mucopolysaccharidosis type IV: A retrospective cohort study from Duhok, Iraq.Cell Mol Biol (Noisy-le-grand)202642758108PubTator, text miningPubMed
The RAMP3 proximity interactor MYO6 determines spatiotemporal signaling of the GPCR CLR in lymphatic endothelial cells.Sci Signal202642743267PubTator, text miningPubMed
Potential role of 5-HT7 receptor antagonists in the treatment of depression: Pharmacological and bioengineering perspectives.Prog Neuropsychopharmacol Biol Psychiatry202642700946PubTator, text miningPubMed
Morquio syndrome masquerading as juvenile idiopathic Arthritis: A case report.Radiol Case Rep202642597981PubTator, text miningPubMed
In vivo genome-wide CRISPR screens of human T cells in solid tumours.Nature202642587162PubTator, text miningPubMed
Pharmacological and Transcriptomic Exploration of β2-Adrenergic Receptor-Gα15 Signaling in THP-1-Derived Macrophages.bioRxiv202642327218PubTator, text miningPubMed
Correction to "Computational Prediction of Deleterious SNPs in the GALNS Gene Implicated in Morquio A Syndrome (MPS IVA)".ACS Omega202642255592PubTator, text miningPubMed
Characterization of Lysosomal Hydrolases and Transporters and Their Age-Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs.Clin Pharmacol Ther202642198901PubTator, text miningPubMed
Longitudinal Multi-Omics Profiling of Aqueous Humor Implicates GALNS Depletion as a Pro-Fibrotic Mediator of Anti-VEGF Therapy in PDR.Invest Ophthalmol Vis Sci202642149029PubTator, text miningPubMed

1 to 10 of 3,532

See all 3,532 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2588

GET https://conductscience.org/api/genes/v1/2588/patents?page=2