Gene · 25913
POT1: protection of telomeres 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. POT1: protection of telomeres 1. Genes, record 25913. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/25913
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NUX5 | Protection of telomeres protein 1 | 634 | 14 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 7458 | Q9NUX5 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1109 | Q9NUX5 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7429 | Q9NUX5 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1109 | Q9NUX5 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7429 | Q9NUX5 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7458 | Q9NUX5 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7842 | Q9NUX5 | Espacenet |
| US 11504404 B2 | 2022-11-22 | 210 | Q9NUX5 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 67980 | Q9NUX5 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 170951 | Q9NUX5 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,830
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | POT1 papers | Newest fiscal year |
|---|---|---|---|
| R01AG016642 | Mechanism of the telomeric proliferation limit | 24 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 19 | 2025 |
| R01CA207342 | Roles of Telomeric Oxidative DNA Lesions in Telomere Length Regulation | 13 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 12 | 2025 |
| R35CA210036 | Genome instability in cancer: telomeres and DNA repair | 11 | 2025 |
| ZIACP010190 | Genetic Epidemiology of Telomere Maintenance and Cancer Etiology | 11 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 10 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 10 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
1 to 10 of 1,830Source NIH's project files
See all 1,830 nih grantsPapers2,597
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Beyond End Protection: Shelterin, POT1 Dysfunction, and Telomere Replication Stress in Cancer. | Biomolecules | 2026 | 42793176 | PubTator, text mining | PubMed |
| Paired Whole-Genome Sequencing of Scalp Angiosarcoma and Matched Lung Metastasis Reveals Common Clonal Origin and Lung-Specific Evolution. | Diagnostics (Basel) | 2026 | 42739253 | PubTator, text mining | PubMed |
| Demographics and factors influencing mortality among cardiac angiosarcoma patients and genomic studies correlation for future personalized management. | Proc (Bayl Univ Med Cent) | 2026 | 42659620 | PubTator, text mining | PubMed |
| Germline POT1 variants are associated with long telomeres and an unexpected broad spectrum of malignancies. | Genet Med Open | 2026 | 42656847 | PubTator, text mining | PubMed |
| Patient-partnered multiomics reveals the molecular architecture of angiosarcoma. | Nat Commun | 2026 | 42642422 | PubTator, text mining | PubMed |
| Familial melanoma: genetic, clinical, and dermoscopic insights and follow-up. | Front Med (Lausanne) | 2026 | 42577103 | PubTator, text mining | PubMed |
| Primary pulmonary presentation extranodal NK/T-cell lymphoma, small cell variant, illustrating the value of flow EBER in situ hybridisation assay. | J Hematop | 2026 | 42567998 | PubTator, text mining | PubMed |
| Novel blood lncRNA biomarkers associated with clinical severity and specific cognitive dimensions in Alzheimer's disease. | J Alzheimers Dis | 2026 | 42523149 | PubTator, text mining | PubMed |
| Telomere stability pathway genes as predictors of susceptibility and prognosis in urothelial bladder cancer: review and bioinformatics analyses. | J Toxicol Environ Health B Crit Rev | 2026 | 42521654 | PubTator, text mining | PubMed |
| Multiple Primary Melanomas and Metastatic Neuroendocrine Tumor in a POT1 Pathogenic Variant Carrier. | Int J Dermatol | 2026 | 42509648 | PubTator, text mining | PubMed |
1 to 10 of 2,597
See all 2,597 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/25913
GET https://conductscience.org/api/genes/v1/25913/patents?page=2