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Gene · 25937

WWTR1: WW domain containing transcription regulator 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. WWTR1: WW domain containing transcription regulator 1. Genes, record 25937. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/25937

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Gene

Symbol
WWTR1
HGNC
Name
WW domain containing transcription regulator 1
HGNC
NCBI Gene ID
25937
NCBI Gene
HGNC ID
HGNC:24042
HGNC
Ensembl
ENSG00000018408
NCBI Gene
Aliases
DKFZp586I1419, TAZ
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9GZV5WW domain-containing transcription regulator protein 140011Ensembl, GeneID, HGNC

Source UniProt

Patents80

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12653785 B22026-06-161Q9GZV5Espacenet
EP 4724572 A12026-04-153Q9GZV5Espacenet
EP 4650780 A22025-11-197806Q9GZV5Espacenet
JP 2025517970 A2025-06-127806Q9GZV5Espacenet
EP 4424837 A22024-09-0413Q9GZV5Espacenet
US 11976302 B22024-05-0713Q9GZV5Espacenet
US 11672795 B22023-06-131Q9GZV5Espacenet
US 11564998 B22023-01-316020Q9GZV5Espacenet
US 11564998 B22023-01-318229Q9GZV5Espacenet
US 11564998 B22023-01-318235Q9GZV5Espacenet

1 to 10 of 80

See all 80 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,305

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleWWTR1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant362025
P30CA016672Cancer Center Support Grant222025
P50CA217694SPORE in Soft Tissue Sarcoma122025
P30CA016056Roswell Park Cancer Center Support Grant82025
R01HL092961Epithelial-Mesenchymal Interactions in Fibrosis Resolution82025
P30CA086862Cancer Center Support Grant62025
P30DK026743UCSF Liver Center62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
T32HL007035Biology of the Lung: A Multidisciplinary Program52025
K08EY031755Investigating mechanosensation in the glaucomatous optic nerve head42025

1 to 10 of 1,305Source NIH's project files

See all 1,305 nih grants

Papers2,228

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity.Curr Issues Mol Biol202642793248PubTator, text miningPubMed
Hippo-YAP/TAZ signaling in gastric cancer: orchestrating epithelial-stromal heterogeneity, plasticity, and therapy resistance.Cancer Heterog Plast202642770147PubTator, text miningPubMed
Ciliary Ift20 and Wwtr1 Coordinate Transforming Growth Factor-β Receptor II Signaling to Maintain Bone-Fat Balance in Skeletal Homeostasis.MedComm (2020)202642769548PubTator, text miningPubMed
Integrative transcriptomic, spatial and functional-genomic analysis identifies a UFMylation-related vascular-stromal program and prioritizes WWTR1 in glioblastoma.Funct Integr Genomics202642747617PubTator, text miningPubMed
From Stone to Sponge: Hippo/YAP Mechanotransduction Empowers Cell Fates and Functions in Bone and Liver.Cold Spring Harb Perspect Biol202642697695PubTator, text miningPubMed
Safety Lessons for YAP/TAZ-TEAD Inhibition: From Mechanism to Translation.Cold Spring Harb Perspect Biol202642697694PubTator, text miningPubMed
Aberrant SOX9 expression mediated by protumour macrophages predicts poorer clinical outcomes in hepatoblastoma.J Pathol202642657494PubTator, text miningPubMed
Co-localization of TAZ and H2A.Z up-regulates IL-6 expression in alveolar epithelial cells to polarize M2 cells to alleviate hypoxia-induced lung injury.Genes Dis202642620447PubTator, text miningPubMed
The phosphoproteome of ovarian carcinoma delineates signaling signatures and potentially druggable targets across histotype stages.NPJ Precis Oncol202642601376PubTator, text miningPubMed
Potential Ferroptosis-Related Genes and Immune Infiltration in Form-Deprivation Myopia: An Integrative Bioinformatics and in vitro Validation Study.Int J Gen Med202642577931PubTator, text miningPubMed

1 to 10 of 2,228

See all 2,228 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/25937

GET https://conductscience.org/api/genes/v1/25937/patents?page=2