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Gene · 2596

GAP43: growth associated protein 43

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GAP43: growth associated protein 43. Genes, record 2596. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2596

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Gene

Symbol
GAP43
HGNC
Name
growth associated protein 43
HGNC
NCBI Gene ID
2596
NCBI Gene
HGNC ID
HGNC:4140
HGNC
Ensembl
ENSG00000172020
NCBI Gene
Aliases
B-50, GAP-43, PP46
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17677Neuromodulin2380Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12636345 B22026-05-2646P17677Espacenet
JP 2026004568 A2026-01-1448311P17677Espacenet
JP 2025032204 A2025-03-1128878P17677Espacenet
EP 4461818 A22024-11-1328878P17677Espacenet
US 12090170 B22024-09-1746P17677Espacenet
JP 2023058610 A2023-04-2528878P17677Espacenet
US 11446398 B22022-09-2036433P17677Espacenet
JP 2022524081 A2022-04-27139404P17677Espacenet
US 10941186 B22021-03-0943P17677Espacenet
EP 3773633 A12021-02-1746P17677Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,354

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGAP43 papersNewest fiscal year
P30CA008748Cancer Center Support Grant82025
U19AG024904Alzheimer's Disease Neuroimaging Initiative (ADNI4)62025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
ZIAAG000975ALZHEIMERS RESEARCH PROJECT / CLINICAL PROJECT: Mechanistic and clinical studies in Alzheimer's disease and related disorders52025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA014051Cancer Center Support (Core) Grant32025
P30CA054174Mays Cancer Center at UT Health SA32025
P30EY026877Stanford Vision Research Core32025
R01AG083874Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in blood32025
R01AI125244Neurotropic herpesvirus envelopment and microtubule-mediated transport32025

1 to 10 of 2,354Source NIH's project files

See all 2,354 nih grants

Papers3,821

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Schwann Cell Expression Pattern in Human Melanomas: In Silico and Immunohistochemical Analyses.Int J Mol Sci202642794688PubTator, text miningPubMed
[Laryngeal squamous cell carcinoma-derived exosomes promote neuronal axonal growth by remodeling the neural microenvironment].Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi202642706064PubTator, text miningPubMed
Non-invasive radiogenomic assessment of growth-associated protein 43 in lung adenocarcinoma brain metastases.Eur J Radiol202642648196PubTator, text miningPubMed
Decreased cerebrospinal fluid NDRG2 is associated with non-Alzheimer's disease derived mild cognitive impairment.J Alzheimers Dis202642593291PubTator, text miningPubMed
Painful neuromas exhibit axonal phenotypic shift via nociceptive and mechanosensitive marker up-regulation.PNAS Nexus202642582843PubTator, text miningPubMed
Actin, connexin-43 and GAP-43 expression in gliomas: real-world associations with IDH status, tumor burden and survival.J Neurooncol202642570146PubTator, text miningPubMed
Elevated CSF GAP-43 is associated with reduced cerebral glucose metabolism and cognitive impairment in individuals with mild cognitive impairment.Brain Imaging Behav202642489996PubTator, text miningPubMed
Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study.Mol Biomed202642455424PubTator, text miningPubMed
Aquaporin-4 Localization in Terminal Glial Cells of Human Mechanosensory Corpuscles: An Immunohistochemical Study of Penile Tissues.J Histochem Cytochem202642394629PubTator, text miningPubMed
APOE ε4-specific associations between agitation, cerebrospinal fluid biomarkers, and cognitive decline in cognitively impaired patients.J Alzheimers Dis202642377429PubTator, text miningPubMed

1 to 10 of 3,821

See all 3,821 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2596

GET https://conductscience.org/api/genes/v1/2596/patents?page=2