Gene · 2596
GAP43: growth associated protein 43
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GAP43: growth associated protein 43. Genes, record 2596. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2596
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P17677 | Neuromodulin | 238 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents33
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12636345 B2 | 2026-05-26 | 46 | P17677 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 48311 | P17677 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 28878 | P17677 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 28878 | P17677 | Espacenet |
| US 12090170 B2 | 2024-09-17 | 46 | P17677 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 28878 | P17677 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 36433 | P17677 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 139404 | P17677 | Espacenet |
| US 10941186 B2 | 2021-03-09 | 43 | P17677 | Espacenet |
| EP 3773633 A1 | 2021-02-17 | 46 | P17677 | Espacenet |
1 to 10 of 33
See all 33 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,354
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GAP43 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| U19AG024904 | Alzheimer's Disease Neuroimaging Initiative (ADNI4) | 6 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 5 | 2025 |
| ZIAAG000975 | ALZHEIMERS RESEARCH PROJECT / CLINICAL PROJECT: Mechanistic and clinical studies in Alzheimer's disease and related disorders | 5 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 3 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 3 | 2025 |
| P30EY026877 | Stanford Vision Research Core | 3 | 2025 |
| R01AG083874 | Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in blood | 3 | 2025 |
| R01AI125244 | Neurotropic herpesvirus envelopment and microtubule-mediated transport | 3 | 2025 |
1 to 10 of 2,354Source NIH's project files
See all 2,354 nih grantsPapers3,821
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Schwann Cell Expression Pattern in Human Melanomas: In Silico and Immunohistochemical Analyses. | Int J Mol Sci | 2026 | 42794688 | PubTator, text mining | PubMed |
| [Laryngeal squamous cell carcinoma-derived exosomes promote neuronal axonal growth by remodeling the neural microenvironment]. | Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | 2026 | 42706064 | PubTator, text mining | PubMed |
| Non-invasive radiogenomic assessment of growth-associated protein 43 in lung adenocarcinoma brain metastases. | Eur J Radiol | 2026 | 42648196 | PubTator, text mining | PubMed |
| Decreased cerebrospinal fluid NDRG2 is associated with non-Alzheimer's disease derived mild cognitive impairment. | J Alzheimers Dis | 2026 | 42593291 | PubTator, text mining | PubMed |
| Painful neuromas exhibit axonal phenotypic shift via nociceptive and mechanosensitive marker up-regulation. | PNAS Nexus | 2026 | 42582843 | PubTator, text mining | PubMed |
| Actin, connexin-43 and GAP-43 expression in gliomas: real-world associations with IDH status, tumor burden and survival. | J Neurooncol | 2026 | 42570146 | PubTator, text mining | PubMed |
| Elevated CSF GAP-43 is associated with reduced cerebral glucose metabolism and cognitive impairment in individuals with mild cognitive impairment. | Brain Imaging Behav | 2026 | 42489996 | PubTator, text mining | PubMed |
| Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study. | Mol Biomed | 2026 | 42455424 | PubTator, text mining | PubMed |
| Aquaporin-4 Localization in Terminal Glial Cells of Human Mechanosensory Corpuscles: An Immunohistochemical Study of Penile Tissues. | J Histochem Cytochem | 2026 | 42394629 | PubTator, text mining | PubMed |
| APOE ε4-specific associations between agitation, cerebrospinal fluid biomarkers, and cognitive decline in cognitively impaired patients. | J Alzheimers Dis | 2026 | 42377429 | PubTator, text mining | PubMed |
1 to 10 of 3,821
See all 3,821 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2596
GET https://conductscience.org/api/genes/v1/2596/patents?page=2