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Gene · 25978

CHMP2B: charged multivesicular body protein 2B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHMP2B: charged multivesicular body protein 2B. Genes, record 25978. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/25978

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Gene

Symbol
CHMP2B
HGNC
Name
charged multivesicular body protein 2B
HGNC
NCBI Gene ID
25978
NCBI Gene
HGNC ID
HGNC:24537
HGNC
Ensembl
ENSG00000083937
NCBI Gene
Aliases
ALS17, CHMP2.5, DKFZP564O123, DMT1, FTDALS7, VPS2-2, VPS2B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UQN3Charged multivesicular body protein 2b2131Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440969Q9UQN3Espacenet
EP 4650780 A22025-11-192254Q9UQN3Espacenet
WO 2025186293 A12025-09-121Q9UQN3Espacenet
JP 2025517970 A2025-06-122254Q9UQN3Espacenet
JP 2025062601 A2025-04-1496Q9UQN3Espacenet
US 11446398 B22022-09-2014490Q9UQN3Espacenet
JP 2022524081 A2022-04-27117461Q9UQN3Espacenet
JP 2022523514 A2022-04-2596Q9UQN3Espacenet
JP 2019054813 A2019-04-11221404Q9UQN3Espacenet
JP 2017121241 A2017-07-13221404Q9UQN3Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,074

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHMP2B papersNewest fiscal year
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions302025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)92025
T32AG023481Multidisciplinary Research Fellowship in Alzheimer’s disease and Related Dementias62025
R01NS101986Understanding Frontotemporal Dementia Using Drosophila and iPSC Models52025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study42025
P20GM103423The Maine Biomedical Research Network (INBRE)42025
R01AG031867Protein aggregation in inclusion body and myofibrillar myopathies42025
R01NS088448Function of TMEM106B in Neurodegeneration42025
R37AI051174Biochemistry of HIV-1 Budding42025
ZIAAG000975ALZHEIMERS RESEARCH PROJECT / CLINICAL PROJECT: Mechanistic and clinical studies in Alzheimer's disease and related disorders42025

1 to 10 of 1,074Source NIH's project files

See all 1,074 nih grants

Papers1,597

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cumulative and Interactive Effects of Heavy Metal Mixtures Across Neurodegenerative Diseases: A Comparative Review of Alzheimer, Parkinson, Amyotrophic Lateral Sclerosis and Multiple Sclerosis.J Xenobiot202642783617PubTator, text miningPubMed
Ferroptosis-neuroinflammation interplay: mechanistic pathways and therapeutic opportunities in central nervous system disorders.Front Aging Neurosci202642755568PubTator, text miningPubMed
A novel CHMP2B variant of uncertain significance in a patient with apathy, hyperorality, and mild language impairment.Acta Neurol Belg202642384158PubTator, text miningPubMed
The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.Dev Cell202642349418PubTator, text miningPubMed
5mC and 6mA DNA Methylation in the Fungal Kingdom: From Genome Defense to Epigenetic Regulation.Epigenomes202642346032PubTator, text miningPubMed
Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies.Brain Pathol202642338253PubTator, text miningPubMed
CHMP2B p.Ala30Ser Variant in Biomarker-Confirmed Early-Onset Alzheimer Disease: A Potential Endolysosomal Disease Modifier.Alzheimer Dis Assoc Disord202642246690PubTator, text miningPubMed
Astrocytic Ferroptosis: An Integrative Hub Linking Metabolic Dyshomeostasis, Glial Crosstalk, and Neurodegeneration in Alzheimer's Disease.Aging Dis202642234965PubTator, text miningPubMed
Molecular Mechanisms of Manganese Oxide Nanoparticles Toxicity in Brain and Other Tissues: An Overview.Front Biosci (Landmark Ed)202642216548PubTator, text miningPubMed
Lycopene alleviates zearalenone-induced endometrial ferroptosis in early pregnant sows by activating the Nrf2/GPX4 pathway.Ecotoxicol Environ Saf202642208377PubTator, text miningPubMed

1 to 10 of 1,597

See all 1,597 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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