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Gene · 25996

REXO2: RNA exonuclease 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. REXO2: RNA exonuclease 2. Genes, record 25996. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/25996

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Gene

Symbol
REXO2
HGNC
Name
RNA exonuclease 2
HGNC
NCBI Gene ID
25996
NCBI Gene
HGNC ID
HGNC:17851
HGNC
Ensembl
ENSG00000076043
NCBI Gene
Aliases
CGI-114, DKFZP566E144, REX2, RFN, SFN
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y3B8Oligoribonuclease, mitochondrial23710Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461602Q9Y3B8Espacenet
EP 4650780 A22025-11-192534Q9Y3B8Espacenet
JP 2025517970 A2025-06-122534Q9Y3B8Espacenet
US 12084509 B22024-09-1010Q9Y3B8Espacenet
US 11446398 B22022-09-2075520Q9Y3B8Espacenet
US 11446398 B22022-09-2075530Q9Y3B8Espacenet
JP 2022524081 A2022-04-27178491Q9Y3B8Espacenet
JP 2022524081 A2022-04-27178501Q9Y3B8Espacenet
US 11078247 B22021-08-039509Q9Y3B8Espacenet
JP 2021018154 A2021-02-15845Q9Y3B8Espacenet

1 to 10 of 15

See all 15 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants886

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleREXO2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P01CA100730Retrovirus Models of Cancer62025
P30CA046934University of Colorado Cancer Center Support Grant52025
P30CA047904Cancer Center Support Grant42025
P30CA008748Cancer Center Support Grant32025
P30CA016058Cancer Center Support Grant32025
P30CA030199Cancer Center Support Grant (CCSG)32025
P30CA034196Cancer Center Support (CORE) Grant32025
P30CA014236Cancer Center Support Grant (CCSG)22025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant22025

1 to 10 of 886Source NIH's project files

See all 886 nih grants

Papers1,535

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cytologic Sub-Categorization of Bethesda Category IV Nodules Has Significant Clinicopathologic Outcomes.Cytopathology202642827277PubTator, text miningPubMed
AI-powered histopathology classifiers identify transcriptomic biomarkers associated with cell cycle regulation and increased mitotic activity in poorly differentiated neuroendocrine carcinoma.Hum Genomics202642800881PubTator, text miningPubMed
Associations of long-term PM2.5 exposure and genetic susceptibility with prevalent metabolic syndrome and subsequent cardiovascular disease risk: A UK Biobank cohort study.Ecotoxicol Environ Saf202642743706PubTator, text miningPubMed
Exploratory Multi-Platform Bioinformatic Analysis of MEAK7 and Its Molecular, Survival, and Immune Associations in Pancreatic Ductal Adenocarcinoma.Int J Mol Sci202642737511PubTator, text miningPubMed
Cognitive heterogeneity in major depressive disorder: Neuroimaging, transcriptomic, and neurotransmitter profiles.Psychiatry Clin Neurosci202642704208PubTator, text miningPubMed
Loss of epitranscriptomic mitochondrial RNA surveillance drives epithelial type I interferon and inflammation in autoimmunity.Proc Natl Acad Sci U S A202642636376PubTator, text miningPubMed
Des-Gamma-Carboxy Prothrombin Is Associated With Tumor Aggressiveness and Recurrence in Resected Early-Stage Hepatocellular Carcinoma: A Clinicopathological and Molecular Analysis.Hepatol Res202642592951PubTator, text miningPubMed
Stress-specific 14-3-3-client modules in digestive cancers: an evidence-graded review of adaptive survival and therapy resistance.Cancer Biol Ther202642507757PubTator, text miningPubMed
Study on the mechanism of TP53 degradation by SFN ubiquitination affecting locally advanced TC progression.Front Chem202642444845PubTator, text miningPubMed
Hydrogen sulfide modulates gene networks in hypoxia/reoxygenation-stressed trophoblasts: insights from transcriptome profiling.Front Bioinform202642382641PubTator, text miningPubMed

1 to 10 of 1,535

See all 1,535 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/25996

GET https://conductscience.org/api/genes/v1/25996/patents