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Gene · 26119

LDLRAP1: low density lipoprotein receptor adaptor protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LDLRAP1: low density lipoprotein receptor adaptor protein 1. Genes, record 26119. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/26119

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Gene

Symbol
LDLRAP1
HGNC
Name
low density lipoprotein receptor adaptor protein 1
HGNC
NCBI Gene ID
26119
NCBI Gene
HGNC ID
HGNC:18640
HGNC
Ensembl
ENSG00000157978
NCBI Gene
Aliases
ARH, ARH1, ARH2, DKFZp586D0624, FHCB1, FHCB2, FHCL4, MGC34705
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q5SW96Low density lipoprotein receptor adapter protein 13081Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21413Q5SW96Espacenet
JP 2026004568 A2026-01-1451912Q5SW96Espacenet
EP 4650780 A22025-11-199451Q5SW96Espacenet
EP 4641202 A22025-10-295617Q5SW96Espacenet
JP 2025517970 A2025-06-129451Q5SW96Espacenet
KR 1020250017231 A2025-02-045617Q5SW96Espacenet
US 11884978 B22024-01-30572Q5SW96Espacenet
JP 2023521663 A2023-05-25412Q5SW96Espacenet
US 11446398 B22022-09-2047191Q5SW96Espacenet
JP 2022524081 A2022-04-27150162Q5SW96Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants788

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLDLRAP1 papersNewest fiscal year
ZIAHL000659ADP-ribosylation Cycles92025
ZIAHD008814Mammalian iron-sulfur cluster biogenesis52025
P30CA008748Cancer Center Support Grant42025
T32DK007120Diabetes and Related Metabolic Diseases32025
P30CA016672Cancer Center Support Grant22025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center22025
P30CA086862Cancer Center Support Grant22025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)22025
P30DK020572Michigan Diabetes Research Center (MDRC)22025
P30DK020595Diabetes Research and Training Center22025

1 to 10 of 788Source NIH's project files

See all 788 nih grants

Papers1,449

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
In vitro analysis of the effects of intronic variants c.940+3_940+6del, c.941-3C>G, and c.2389+5G>A in the LDLR gene on pre-mRNA splicing using a minigene assay.Vavilovskii Zhurnal Genet Selektsii202642824094PubTator, text miningPubMed
Association of ABO Blood Groups with HPV Genotypes and Cervical Lesions in HPV-Positive Women.Int J Womens Health202642733863PubTator, text miningPubMed
Autosomal Recessive Hypercholesterolemia Due to a Novel Homozygous LDLRAP1 Frameshift Mutation.JACC Case Rep202642730734PubTator, text miningPubMed
Genetic Spectrum of Familial Hypercholesterolemia in Russian North-West Registry: Focus on Correlation Between Clinical and Genetic Diagnosis.J Cardiovasc Dev Dis202642645855PubTator, text miningPubMed
How the genetic diagnosis of familial hypercholesterolemia can be guided by clinical features. Preliminary evidences from an Italian single-center experience.Acta Diabetol202642570019PubTator, text miningPubMed
Evinacumab Treatment of Homozygous Familial Hypercholesterolemia Patients in a Real-World Setting: An Overview After the First Year of Therapy.AACE Endocrinol Diabetes202642491512PubTator, text miningPubMed
Genetic yield of next-generation sequencing for detecting monogenic familial hypercholesterolemia in uzbek patients with coronary artery disease.PLoS One202642424361PubTator, text miningPubMed
Lipid Metabolic Reprogramming and Epigenetic Co-Dysregulation Across the Central Chondrosarcoma Grade Spectrum: A Multi-Cohort RNA-seq Study.Int J Mol Sci202642353027PubTator, text miningPubMed
Management of autosomal recessive hypercholesterolemia in a patient with an LDLRAP1 mutation.J Clin Lipidol202642336686PubTator, text miningPubMed
mTORC1-signaling switches megalin function from endocytosis to cell cycle progression.Cell Mol Life Sci202642174246PubTator, text miningPubMed

1 to 10 of 1,449

See all 1,449 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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