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Gene · 26121

PRPF31: pre-mRNA processing factor 31

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRPF31: pre-mRNA processing factor 31. Genes, record 26121. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/26121

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Gene

Symbol
PRPF31
HGNC
Name
pre-mRNA processing factor 31
HGNC
NCBI Gene ID
26121
NCBI Gene
HGNC ID
HGNC:15446
HGNC
Ensembl
ENSG00000105618
NCBI Gene
Aliases
NY-BR-99, PRP31, RP11, SNRNP61, hPrp31
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8WWY3U4/U6 small nuclear ribonucleoprotein Prp3149930Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19281Q8WWY3Espacenet
JP 2026004568 A2026-01-1460400Q8WWY3Espacenet
EP 4667578 A22025-12-24148Q8WWY3Espacenet
EP 4667578 A22025-12-24149Q8WWY3Espacenet
EP 4650780 A22025-11-195535Q8WWY3Espacenet
JP 2025131621 A2025-09-09148Q8WWY3Espacenet
JP 2025131621 A2025-09-09149Q8WWY3Espacenet
JP 2025517970 A2025-06-125535Q8WWY3Espacenet
WO 2024214081 A12024-10-17281Q8WWY3Espacenet
US 11446398 B22022-09-2066451Q8WWY3Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,434

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRPF31 papersNewest fiscal year
P30CA008748Cancer Center Support Grant332025
P30EY014104P30 Core Grant for Vision Research112025
R01EY018213Defining Barriers to Gene Therapy112025
R01EY022356Molecular Basis of Human Visual System Disorders112025
R01EY012910Precision Medicine for Inherited Retinal Degenerations102025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant82025
P30CA021765Cancer Center Support Grant (CCSG)82025
R01EY018571Genetics of early onset retinal diseases82025
P30CA013696Cancer Center Support Grant72025

1 to 10 of 2,434Source NIH's project files

See all 2,434 nih grants

Papers3,060

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Protective effects of sarcopenia-related traits on spinal degenerative diseases: A large prospective cohort study.Bone202742790802PubTator, text miningPubMed
From splice defect to therapeutic opportunity: Insights from PRPF31.Mol Ther202642822454PubTator, text miningPubMed
Cell-autonomous restoration of splicing homeostasis and RP11 phenotype in patient-derived RPE and retinal organoids by PRPF31.AAV gene therapy.Nat Commun202642816512PubTator, text miningPubMed
Functional Genomic Screening Identifies lncRNA CNPY2-AS1 as a Regulator of Redox Metabolism and Antiviral Immunity.Int J Biol Sci202642807861PubTator, text miningPubMed
A novel PRPF31 variant associated with autosomal dominant retinitis pigmentosa in Japanese families.Ophthalmic Genet202642768956PubTator, text miningPubMed
Genome-wide association meta-analysis of eating behavior traits revealed one susceptibility locus for emotional eating.Mol Psychiatry202642736351PubTator, text miningPubMed
Overexpression of the Yes-associated Protein 1 Promoter-associated Long Noncoding RNA RP11-732A21.3 Enhances E-cadherin-dependent Cellular Cohesiveness during Anchorage-independent Growth in Colon Cancer.
J Physiol Investig202642725672PubTator, text miningPubMed
Mesenchymal drift in ciliopathy iPSC-derived RPE reveals a convergent pathogenic cell state.Cell Rep202642667617PubTator, text miningPubMed
Non-syndromic adult-onset rod-cone dystrophy.Retina202642627262PubTator, text miningPubMed
Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harb Perspect Biol202642575696PubTator, text miningPubMed

1 to 10 of 3,060

See all 3,060 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/26121

GET https://conductscience.org/api/genes/v1/26121/patents?page=2