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Gene · 26168

SENP3: SUMO specific peptidase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SENP3: SUMO specific peptidase 3. Genes, record 26168. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/26168

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Gene

Symbol
SENP3
HGNC
Name
SUMO specific peptidase 3
HGNC
NCBI Gene ID
26168
NCBI Gene
HGNC ID
HGNC:17862
HGNC
Ensembl
ENSG00000161956
NCBI Gene
Aliases
DKFZP586K0919, DKFZp762A152, SMT3IP1, SSP3, Ulp1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H4L4Sentrin-specific protease 35741Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465793Q9H4L4Espacenet
EP 4650780 A22025-11-194937Q9H4L4Espacenet
JP 2025517970 A2025-06-124937Q9H4L4Espacenet
US 11446398 B22022-09-2084957Q9H4L4Espacenet
US 11446398 B22022-09-2084958Q9H4L4Espacenet
JP 2022524081 A2022-04-27187928Q9H4L4Espacenet
JP 2022524081 A2022-04-27187929Q9H4L4Espacenet
US 11078247 B22021-08-0310097Q9H4L4Espacenet
JP 2019054813 A2019-04-11246228Q9H4L4Espacenet
JP 2017121241 A2017-07-13246228Q9H4L4Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,349

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSENP3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant302025
R35GM119721Diversity Supplement: Mechanistic Insights into Mammalian DNA Methylation142025
P30GM124165NE-CAT: A Resource for Advanced Macromolecular Crystallography62025
R35GM118047Structural studies of viral replication and invasion62025
P30CA016086Cancer Center Support Grant52025
P30CA033572Cancer Center Support Grant52025
R01ES007061Mechanisms of DNA Double-strand Break End Resection and Repair Pathway Choice52025
P30CA016672Cancer Center Support Grant42025
P30CA042014Cancer Center Support Grant42025
R01AI124491NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing42025

1 to 10 of 1,349Source NIH's project files

See all 1,349 nih grants

Papers1,697

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
GNL3 SUMOylation is essential for DNA double-strand break repair by homologous recombination.Nat Commun202642773178PubTator, text miningPubMed
SEPT5 confers radioresistance by suppressing GSDME-dependent pyroptosis and antitumor immunity in non-small cell lung cancer.Int Immunopharmacol202642743876PubTator, text miningPubMed
SUMOylated Reptin maintains low intracellular ROS levels by activating mitophagy to drive gemcitabine resistance in gallbladder cancer.Cell Death Dis202642716921PubTator, text miningPubMed
CHTOP regulates the NRF2/HO-1 axis to modulate chemoresistance in colorectal cancer.Redox Biol202642617575PubTator, text miningPubMed
RETRACTION: SENP3-Mediated TIP60 deSUMOylation is Required for DNA-PKcs Activity and DNA Damage Repair.MedComm (2020)202642577889PubTator, text miningPubMed
Revisiting mid-long term ecosystem services projections: Integrating the interaction effects of future climate and land use changes.Fundam Res202642272478PubTator, text miningPubMed
SENP3 Exacerbates Spinal Cord Injury by Increasing H6PD deSUMOylation to Promote Glycolysis.FASEB J202642247250PubTator, text miningPubMed
Structure of the E3 ligase CRL2ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination.Cell Rep202642224082PubTator, text miningPubMed
Correction: SENP3 promotes tumor progression and is a novel prognostic biomarker in triple-negative breast cancer.Front Oncol202642205760PubTator, text miningPubMed
SENP3 regulates DNA damage repair by downregulating RAP80 SUMOylation.Acta Biochim Biophys Sin (Shanghai)202642093510PubTator, text miningPubMed

1 to 10 of 1,697

See all 1,697 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/26168

GET https://conductscience.org/api/genes/v1/26168/patents?page=2