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Gene · 2617

GARS1: glycyl-tRNA synthetase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GARS1: glycyl-tRNA synthetase 1. Genes, record 2617. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2617

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Gene

Symbol
GARS1
HGNC
Name
glycyl-tRNA synthetase 1
HGNC
NCBI Gene ID
2617
NCBI Gene
HGNC ID
HGNC:4162
HGNC
Ensembl
ENSG00000106105
NCBI Gene
Aliases
CMT2D, DSMAV, GARS, GlyRS, HMN5, HMN5A, HMND5, SMAD1, SMAJI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41250Glycine--tRNA ligase73914Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448078P41250Espacenet
EP 4650780 A22025-11-1910671P41250Espacenet
EP 4641201 A22025-10-2911067P41250Espacenet
JP 2025147176 A2025-10-065797P41250Espacenet
JP 2025529142 A2025-09-046459P41250Espacenet
US 12371689 B22025-07-296459P41250Espacenet
JP 2025517969 A2025-06-1211067P41250Espacenet
JP 2025517970 A2025-06-1210671P41250Espacenet
JP 2025028160 A2025-02-285797P41250Espacenet
KR 1020250010750 A2025-01-215797P41250Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants996

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGARS1 papersNewest fiscal year
R35GM139627Link extracellular function of tRNA synthetase with pathological mechanism of disease62025
P30CA008748Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant52025
P30CA034196Cancer Center Support (CORE) Grant42025
R35GM146860Understanding higher-order glycine receptor assemblies in neurotransmission32025
R37NS054154The Genetics of the Neuromuscular Junction: Mechanisms and Disease Models32025
ZIAAA000407Synaptic Transmission: Modulation, Plasticity And Effects Of Drugs Of Abuse32025
ZIBHG000196Inter- and Intra-Species Comparative Sequencing32025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA010815Consolidated Basic Cancer Research Program22025

1 to 10 of 996Source NIH's project files

See all 996 nih grants

Papers1,667

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Convergent TBK1 loss of function drives gasdermin E dependent pyroptosis and motor neuron degeneration across ALS genotypes.Cell Death Differ202642768102PubTator, text miningPubMed
Case Report: Acute interstitial pneumonia as the initial presentation of Anti-EJ antisynthetase syndrome: a case of severe respiratory failure with rapid response to cyclophosphamide.Front Immunol202642656765PubTator, text miningPubMed
Synaptic vs. Non-Synaptic Glycine Receptors: Physiological Role and Implications in Alzheimer's Disease Pathology.Int J Mol Sci202642511649PubTator, text miningPubMed
Identification of potential key genes that respond to capsaicin treatment in ER-positive breast cancer: An integrated analysis.PLoS One202642234642PubTator, text miningPubMed
A non-proteolytic role of SARS-CoV-2 PLpro in modulating host glycyl-tRNA synthetase activity.J Mol Cell Biol202642133471PubTator, text miningPubMed
Locally synthesized glycyl aminoacyl-tRNA synthetase is important for local translation in neurons.Life Sci Alliance202641986236PubTator, text miningPubMed
Structural basis of human zinc-activated channel (ZAC) signaling and modulation.Cell Discov202641912481PubTator, text miningPubMed
Pharmacogenomic-Based GWAS Meta-Analyses Coupled with Genetic and Epigenetic Liability Testing Connects Facial and Emotional Recognition Systems to Spectrum Disorders, Schizophrenia, Depression, and Anxiety.
Curr Pharm Biotechnol202641830575PubTator, text miningPubMed
Weaker neuroligin 2-neurexin β1 interaction tethers membranes and recruits gephyrin at membrane junctions through clustering.Sci Adv202641824561PubTator, text miningPubMed
Glycine receptors in circulating white blood cells regulated by neuroinflammation.Front Immunol202641808824PubTator, text miningPubMed

1 to 10 of 1,667

See all 1,667 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2617

GET https://conductscience.org/api/genes/v1/2617/patents?page=2