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Gene · 2618

GART: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GART: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase. Genes, record 2618. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2618

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Gene

Symbol
GART
HGNC
Name
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
HGNC
NCBI Gene ID
2618
NCBI Gene
HGNC ID
HGNC:4163
HGNC
Ensembl
ENSG00000159131
NCBI Gene
Aliases
AIRS, GARS, GARS-AIRS-GART, GARTF, PAIS, PGFT, PRGS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22102Trifunctional purine biosynthetic protein adenosine-31,01040Ensembl, GeneID, HGNC

Source UniProt

Patents63

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026042727 A2026-02-261P22102Espacenet
JP 2026004568 A2026-01-1458025P22102Espacenet
JP 2026004568 A2026-01-1458026P22102Espacenet
JP 2026004568 A2026-01-1458027P22102Espacenet
EP 4650780 A22025-11-1910495P22102Espacenet
JP 2025517970 A2025-06-1210495P22102Espacenet
JP 2025024198 A2025-02-1914402P22102Espacenet
JP 2025024198 A2025-02-1914403P22102Espacenet
JP 2025024198 A2025-02-1914404P22102Espacenet
US 11446398 B22022-09-2063608P22102Espacenet

1 to 10 of 63

See all 63 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PELITREXOLCHEMBL2107361GAR transformylase inhibitorINHIBITORChEMBL
PEMETREXEDCHEMBL225072GAR transformylase inhibitorINHIBITORChEMBL
PEMETREXED DIPOTASSIUMCHEMBL6068329GAR transformylase inhibitorINHIBITORChEMBL
PEMETREXED DISODIUMCHEMBL2360464GAR transformylase inhibitorINHIBITORChEMBL
PEMETREXED MONOHYDRATECHEMBL5315053GAR transformylase inhibitorINHIBITORChEMBL
PEMETREXED TROMETHAMINECHEMBL3989962GAR transformylase inhibitorINHIBITORChEMBL

Trials960

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07586202PEMETREXEDPHASE2ClinicalTrials.gov
NCT07554859PEMETREXEDPHASE2ClinicalTrials.gov
NCT07551778PEMETREXEDPHASE1/PHASE2ClinicalTrials.gov
NCT07551414PEMETREXEDPHASE2ClinicalTrials.gov
NCT07538193PEMETREXEDClinicalTrials.gov
NCT07524257PEMETREXEDPHASE3ClinicalTrials.gov
NCT07514793PEMETREXEDPHASE2ClinicalTrials.gov
NCT07507188PEMETREXEDPHASE2ClinicalTrials.gov
NCT07486817PEMETREXEDPHASE2ClinicalTrials.gov
NCT07485179PEMETREXEDClinicalTrials.gov

1 to 10 of 960

See all 960 trials

NIH grants802

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGART papersNewest fiscal year
T32CA009531Training Program in the Biology of Cancer192025
P30CA022453CANCER CENTER SUPPORT GRANT132025
P30CA016672Cancer Center Support Grant102025
P30CA016056Roswell Park Cancer Center Support Grant62025
P30CA021765Cancer Center Support Grant (CCSG)62025
R01CA250469Therapeutic Targeting Mitochondrial C1 Metabolism52025
P30CA046934University of Colorado Cancer Center Support Grant42025
P30ES013508Center of Excellence in Environmental Toxicology42025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes32025
P30CA008748Cancer Center Support Grant32025

1 to 10 of 802Source NIH's project files

See all 802 nih grants

Papers1,092

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Gene Expression Dynamics and Network Analysis Reveal Key Molecular Pathways in Spermatogenic Progression from Spermatogonial Stem Cells to Round Spermatids.Int J Fertil Steril202642703821PubTator, text miningPubMed
A mathematical model of folate-mediated one-carbon metabolism in Down syndrome.NPJ Syst Biol Appl202642362570PubTator, text miningPubMed
Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma.Front Cell Dev Biol202642326014PubTator, text miningPubMed
NPF-Driven Gart Expression Fuels Gut Absorption and Modulates Feeding via a Negative Feedback Loop.Insects202642188194PubTator, text miningPubMed
Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain.Nat Commun202641917044PubTator, text miningPubMed
The oncogenic control of nucleotide synthesis.Oncogenesis202641881963PubTator, text miningPubMed
Reconfigurable intelligent surface and UAV coordination for reliable THz wireless networks.PLoS One202641871129PubTator, text miningPubMed
Superabundant microRNAs are transcribed from human rDNA spacer promoters insulated by CTCF.Sci Adv202641860999PubTator, text miningPubMed
Immunometabolism in lung cancer - The link between metabolism and immune response.iScience202641797927PubTator, text miningPubMed
Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues.Nat Commun202641792114PubTator, text miningPubMed

1 to 10 of 1,092

See all 1,092 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2618

GET https://conductscience.org/api/genes/v1/2618/patents?page=2