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PTPN22: protein tyrosine phosphatase non-receptor type 22

1 protein, 8 patents, 0 drugs, 0 trials, 4,345 NIH grants and 7,514 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPTPN22HGNC
Nameprotein tyrosine phosphatase non-receptor type 22HGNC
NCBI Gene ID26191NCBI Gene
HGNC IDHGNC:9652HGNC
EnsemblENSG00000134242NCBI Gene
AliasesLYP, LYP1, LYP2, Lyp, Lyp1, Lyp2, PEP, PTPN22.5, PTPN22.6, PTPN8NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9Y2R2Tyrosine-protein phosphatase non-receptor type 2280714Ensembl, GeneID, HGNCUniProt

Patents 8

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4426882 A12024-09-11242Q9Y2R2Espacenet
US 11278629 B22022-03-2251Q9Y2R2Espacenet
JP 2020510608 A2020-04-0951Q9Y2R2Espacenet
WO 2018083633 A12018-05-1151Q9Y2R2Espacenet
EP 2831104 A12015-02-0454Q9Y2R2Espacenet
US 6844177 A2005-01-182Q9Y2R2Espacenet
JP 2002513289 A2002-05-0845Q9Y2R2Espacenet
US 6228641 A2001-05-082Q9Y2R2Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 4345

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01CA069202Structure/Function of Protein Tyrosine Phosphatases342,025NIH's project files
P30DK017047Diabetes Research Center212,025NIH's project files
R01DK032083Multiple Autoantigens, Multiple Epitopes of Type 1 Diabetes202,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital182,025NIH's project files
R01AR063759Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state182,025NIH's project files
R01CA053840Protein Tyrosine Dephosphorylation & Signal Transduction172,025NIH's project files
R01AI024717Genetic Linkage in Lupus162,025NIH's project files
P30AR070253Joint Biology Consortium Resource-based Center132,025NIH's project files
P30CA016672Cancer Center Support Grant132,025NIH's project files
P30CA030199Cancer Center Support Grant (CCSG)132,025NIH's project files

Papers 7514

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823085PubTator, text miningPubMed
42790002PubTator, text miningPubMed
42775419PubTator, text miningPubMed
42769759PubTator, text miningPubMed
42742803PubTator, text miningPubMed
42728778PubTator, text miningPubMed
42612262PubTator, text miningPubMed
42554627PubTator, text miningPubMed
42504525PubTator, text miningPubMed
42497245PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license