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Gene · 2621

GAS6: growth arrest specific 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GAS6: growth arrest specific 6. Genes, record 2621. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2621

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Gene

Symbol
GAS6
HGNC
Name
growth arrest specific 6
HGNC
NCBI Gene ID
2621
NCBI Gene
HGNC ID
HGNC:4168
HGNC
Ensembl
ENSG00000183087
NCBI Gene
Aliases
AXLLG, AXSF, DKFZp666G247, FLJ34709
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14393Growth arrest-specific protein 66784Ensembl, GeneID, HGNC

Source UniProt

Patents85

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448293Q14393Espacenet
JP 2026000906 A2026-01-0693Q14393Espacenet
EP 4650780 A22025-11-195930Q14393Espacenet
EP 4640849 A22025-10-29862Q14393Espacenet
EP 4641201 A22025-10-295657Q14393Espacenet
JP 2025147176 A2025-10-065800Q14393Espacenet
KR 1020250136262 A2025-09-1663Q14393Espacenet
JP 2025529142 A2025-09-046461Q14393Espacenet
EP 4602062 A12025-08-207Q14393Espacenet
US 12384822 B22025-08-127Q14393Espacenet

1 to 10 of 85

See all 85 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
BATIRAXCEPTCHEMBL4594462Growth arrest-specific protein 6 inhibitorINHIBITOR

Source ChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05826015BATIRAXCEPTPHASE1ClinicalTrials.gov
NCT04983407BATIRAXCEPTPHASE1/PHASE2ClinicalTrials.gov
NCT04729608BATIRAXCEPTPHASE3ClinicalTrials.gov
NCT04300140BATIRAXCEPTPHASE1/PHASE2ClinicalTrials.gov
NCT04042623BATIRAXCEPTPHASE22022-02-10ClinicalTrials.gov
NCT04019288BATIRAXCEPTPHASE1/PHASE22025-06-11ClinicalTrials.gov
NCT04004442BATIRAXCEPTPHASE1ClinicalTrials.gov
NCT03639246BATIRAXCEPTPHASE1ClinicalTrials.gov
NCT03607955BATIRAXCEPTPHASE1ClinicalTrials.gov

NIH grants2,018

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGAS6 papersNewest fiscal year
P30CA016672Cancer Center Support Grant252025
P30CA046934University of Colorado Cancer Center Support Grant202025
P30CA008748Cancer Center Support Grant162025
P30CA014195Cancer Center Support Grant (CCSG)102025
UL1TR001863Yale Clinical and Translational Science Award92025
P30CA016086Cancer Center Support Grant82025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202872025
P30EY014801Miami Center for Vision Research72025
K12HD000849Reproductive Scientist Development Program62025
P30CA014051Cancer Center Support (Core) Grant62025

1 to 10 of 2,018Source NIH's project files

See all 2,018 nih grants

Papers3,604

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Therapy-educated fibroblast states link treatment pressure to residual disease and acquired resistance in gastric cancer.Front Immunol202642812889PubTator, text miningPubMed
Remote Ischemic Post-Conditioning Preserves the Neurovascular Unit by Brain-Derived Gas6 That Drives Monocyte-Derived Macrophage Reprogramming via Axl and Vimentin after SAH.Adv Sci (Weinh)202642801717PubTator, text miningPubMed
Aberrant expression of MERTK activates BCR via CD79a in CLL cells: alternative therapeutic strategy for relapsed/refractory CLL.Leukemia202642778661PubTator, text miningPubMed
Long non-coding RNA GAS6-AS1 and its molecular mechanisms in human cancer (Review).Biomed Rep202642769717PubTator, text miningPubMed
Single-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance.Cell Rep Med202642748914PubTator, text miningPubMed
AXL mediates influenza A virus entry and drives virus-induced inflammation.Emerg Microbes Infect202642717575PubTator, text miningPubMed
Targeting Compensatory AKT Activation Overcomes Resistance to AXL Inhibition in Acute Lymphoblastic Leukemia.Mol Cancer Ther202642704216PubTator, text miningPubMed
Rosa damascena-derived nanovesicles restore GAS6-driven efferocytic balance in LPS-induced inflammatory model.J Drug Target202642698269PubTator, text miningPubMed
Context-dependent effects of MIR100HG on tumorigenic phenotypes and p38/MAPK-AKT signaling in hepatocellular carcinoma.Funct Integr Genomics202642698010PubTator, text miningPubMed
Expression of TAM receptors and their ligands in unexplained recurrent pregnancy loss.Immunol Res202642684543PubTator, text miningPubMed

1 to 10 of 3,604

See all 3,604 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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