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Gene · 26277

TINF2: TERF1 interacting nuclear factor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TINF2: TERF1 interacting nuclear factor 2. Genes, record 26277. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/26277

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Gene

Symbol
TINF2
HGNC
Name
TERF1 interacting nuclear factor 2
HGNC
NCBI Gene ID
26277
NCBI Gene
HGNC ID
HGNC:11824
HGNC
Ensembl
ENSG00000092330
NCBI Gene
Aliases
DKCA3, DKCA5, TIN2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9BSI4TERF1-interacting nuclear factor 24513Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026027383 A2026-02-1841Q9BSI4Espacenet
EP 4650780 A22025-11-192614Q9BSI4Espacenet
JP 2025147176 A2025-10-0613255Q9BSI4Espacenet
JP 2025147176 A2025-10-0613257Q9BSI4Espacenet
JP 2025529142 A2025-09-047891Q9BSI4Espacenet
US 12371689 B22025-07-297891Q9BSI4Espacenet
JP 2025517970 A2025-06-122614Q9BSI4Espacenet
JP 2025028160 A2025-02-2813255Q9BSI4Espacenet
JP 2025028160 A2025-02-2813257Q9BSI4Espacenet
KR 1020250010750 A2025-01-2113255Q9BSI4Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,403

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTINF2 papersNewest fiscal year
ZIACP010190Genetic Epidemiology of Telomere Maintenance and Cancer Etiology302025
R01AG016642Mechanism of the telomeric proliferation limit182025
ZIACP010144Clinical Genetic Studies of Familial and Hereditary Cancer Syndromes182025
ZIAHL006089Telomere Diseases and Other Constitutional and Acquired Genetic Disorders of Hematopoiesis112025
P30CA010815Consolidated Basic Cancer Research Program92025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant72025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center62025
P30ES025128Center for Human Health and the Environment (CHHE)62025
R01HL131744Molecular Genetics of the Telomere Biology Disorders62025

1 to 10 of 1,403Source NIH's project files

See all 1,403 nih grants

Papers1,630

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Military Veteran with Pulmonary Fibrosis, Hepatic Cirrhosis, Bone Marrow Dysfunction and Shortened Telomeres Found to Have GAVE, a Potential Unsuspected Consequence of Telomere Spectrum Disorder.J Clin Med202642795846PubTator, text miningPubMed
First Experience of TCRαβ⁺ Depleted Haploidentical Hematopoietic Stem Cell Transplantation in a Child with a TINF2-Related Telomere Biology Disorder.Turk J Haematol202642755158PubTator, text miningPubMed
Genomic and computational analysis of variants in telomere regulatory genes in subjects with bone marrow failure.Eur J Hum Genet202642736390PubTator, text miningPubMed
Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant.Pediatr Blood Cancer202642657693PubTator, text miningPubMed
Meiotic telomeres of vole B chromosomes: shelterin and associated proteins provide a link to the nuclear envelope.Chromosome Res202642479255PubTator, text miningPubMed
Suspected parental gonadal/gonadosomatic mosaicism for a TINF2 mutation in two sisters with dyskeratosis congenita.Front Genet202642460152PubTator, text miningPubMed
Outcomes of Dyskeratosis Congenita: Results From the Canadian Inherited Marrow Failure Registry.J Pediatr Hematol Oncol202642267950PubTator, text miningPubMed
Telomere maintaining germline and somatic variants in thyroid cancer and melanoma.medRxiv202642245030PubTator, text miningPubMed
A Case of Long-Term Management of Oral Function in a Child with Dyskeratosis Congenita.Diagnostics (Basel)202642122061PubTator, text miningPubMed
Micronuclei: origins, assays, mechanisms, diseases and treatments.Signal Transduct Target Ther202641888103PubTator, text miningPubMed

1 to 10 of 1,630

See all 1,630 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/26277

GET https://conductscience.org/api/genes/v1/26277/patents?page=2