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GBA1: glucosylceramidase beta 1

1 protein, 281 patents, 2 drugs, 4 trials, 2,662 NIH grants and 6,722 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGBA1HGNC
Nameglucosylceramidase beta 1HGNC
NCBI Gene ID2629NCBI Gene
HGNC IDHGNC:4177HGNC
EnsemblENSG00000177628NCBI Gene
AliasesGBA, GCB, GLUCNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04062Lysosomal acid glucosylceramidase53658Ensembl, GeneID, HGNCUniProt

Patents 281

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4774397 A12026-07-1588P04062Espacenet
EP 4770680 A12026-07-0817P04062Espacenet
JP 2026077678 A2026-05-1393P04062Espacenet
JP 2026071207 A2026-04-281740P04062Espacenet
JP 2026071207 A2026-04-281742P04062Espacenet
JP 2026071207 A2026-04-281744P04062Espacenet
JP 2026071207 A2026-04-281774P04062Espacenet
JP 2026071207 A2026-04-281778P04062Espacenet
JP 2026071207 A2026-04-281782P04062Espacenet
JP 2026067851 A2026-04-21315P04062Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFEGOSTATCHEMBL206468Beta-glucocerebrosidase stabiliserSTABILISERChEMBL
AFEGOSTAT TARTRATECHEMBL2105671Beta-glucocerebrosidase stabiliserSTABILISERChEMBL

Trials 4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00875160AFEGOSTAT TARTRATEPHASE1ClinicalTrials.gov
NCT00813865AFEGOSTAT TARTRATEPHASE22018-08-15ClinicalTrials.gov
NCT00446550AFEGOSTAT TARTRATEPHASE22018-08-15ClinicalTrials.gov
NCT00433147AFEGOSTAT TARTRATEPHASE22018-08-15ClinicalTrials.gov

NIH grants 2662

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAHG200336Genetic and clinical studies of Gaucher disease and other lysosomal disorders992,025NIH's project files
ZIANS003154Genetic characterization of atypical parkinsonism332,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award282,025NIH's project files
P30DK034989Yale Liver Center162,025NIH's project files
R01NS115144Genome-Wide Prediction of Dementia in Parkinson's Disease142,025NIH's project files
P01CA097132Sphingolipids in Cancer Biology and Therapy122,025NIH's project files
R01NS092823The role of a-synuclein accumulation in lysosomal hydrolase trafficking and function112,025NIH's project files
P30AG062677Mayo Alzheimer's Disease Research Center102,025NIH's project files
P30CA008748Cancer Center Support Grant102,025NIH's project files
U01NS100620Longitudinal Imaging Biomarkers of Prodromal DLB92,025NIH's project files

Papers 6722

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825921PubTator, text miningPubMed
42821122PubTator, text miningPubMed
42818089PubTator, text miningPubMed
42817906PubTator, text miningPubMed
42804365PubTator, text miningPubMed
42803978PubTator, text miningPubMed
42801451PubTator, text miningPubMed
42801449PubTator, text miningPubMed
42774662PubTator, text miningPubMed
42774389PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license