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FGF21: fibroblast growth factor 21

1 protein, 330 patents, 0 drugs, 0 trials, 2,845 NIH grants and 6,992 papers.

Gene 6

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFGF21HGNC
Namefibroblast growth factor 21HGNC
NCBI Gene ID26291NCBI Gene
HGNC IDHGNC:3678HGNC
EnsemblENSG00000105550NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9NSA1Fibroblast growth factor 212093Ensembl, GeneID, HGNCUniProt

Patents 330

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777130 A12026-07-221Q9NSA1Espacenet
JP 2026119083 A2026-07-161Q9NSA1Espacenet
JP 2026090244 A2026-06-02246Q9NSA1Espacenet
EP 4705273 A22026-03-11559Q9NSA1Espacenet
US 12559533 B22026-02-241Q9NSA1Espacenet
WO 2026030354 A22026-02-0569Q9NSA1Espacenet
US 12534503 B22026-01-273Q9NSA1Espacenet
US 12527841 B22026-01-201Q9NSA1Espacenet
JP 2025179058 A2025-12-0914Q9NSA1Espacenet
US 12491231 B22025-12-091Q9NSA1Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2845

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK020572Michigan Diabetes Research Center (MDRC)262,025NIH's project files
P30DK072476Pennington/Louisiana NORC252,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)212,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award202,025NIH's project files
P30DK020579Diabetes Research Center192,025NIH's project files
R01DK106104Regulation of Metabolism by FGF21162,025NIH's project files
P30DK056341Washington University Nutrition Obesity Research Center152,025NIH's project files
P30DK063491Diabetes Research Center (DRC)122,025NIH's project files
P30DK120515San Diego Digestive Diseases Research Center122,025NIH's project files
UL1TR002345Washington University Institute of Clinical and Translational Sciences122,025NIH's project files

Papers 6992

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826721PubTator, text miningPubMed
42822678PubTator, text miningPubMed
42818621PubTator, text miningPubMed
42809949PubTator, text miningPubMed
42809027PubTator, text miningPubMed
42807193PubTator, text miningPubMed
42801779PubTator, text miningPubMed
42786201PubTator, text miningPubMed
42781202PubTator, text miningPubMed
42781079PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license