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Gene · 2633

GBP1: guanylate binding protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GBP1: guanylate binding protein 1. Genes, record 2633. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2633

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Gene

Symbol
GBP1
HGNC
Name
guanylate binding protein 1
HGNC
NCBI Gene ID
2633
NCBI Gene
HGNC ID
HGNC:4182
HGNC
Ensembl
ENSG00000117228
NCBI Gene
Aliases
hGBP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P32455Guanylate-binding protein 159212Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448565P32455Espacenet
EP 4650780 A22025-11-198779P32455Espacenet
EP 4641201 A22025-10-298987P32455Espacenet
EP 4641202 A22025-10-29502P32455Espacenet
JP 2025517969 A2025-06-128987P32455Espacenet
JP 2025517970 A2025-06-128779P32455Espacenet
KR 1020250017231 A2025-02-04502P32455Espacenet
JP 2023123507 A2023-09-05110P32455Espacenet
US 11446398 B22022-09-2036948P32455Espacenet
JP 2022524081 A2022-04-27139919P32455Espacenet

1 to 10 of 20

See all 20 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,419

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGBP1 papersNewest fiscal year
P30AG017265USC/UCLA Center on Biodemography and Population Health92025
R01AI139425Interferon-inducible cell-autonomous immunity to cytosolic bacterial pathogens82025
P30CA016672Cancer Center Support Grant62025
R01AI108834GBPs in inflammasome activation and host defense to infection62025
P30CA016058Cancer Center Support Grant52025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital42025
R01GM107285Mechanism and Role of Membrane Fusion by the Atlastin GTPase42025
T32HL007185Multidisciplinary Training Program in Lung Disease42025
UL1TR001863Yale Clinical and Translational Science Award42025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition42025

1 to 10 of 1,419Source NIH's project files

See all 1,419 nih grants

Papers1,970

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exploring Molecular Pathways in Metastasis of Breast Cancer Cells to the Brain: Insights from Gene Expression Analysis and Cellular Origins.J Microsc Ultrastruct202642824931PubTator, text miningPubMed
Gestational week 13 - a critical window for pre-eclampsia pathogenesis: A cell-free RNA gene expression study.Placenta202642762647PubTator, text miningPubMed
Gut Dysbiosis Promotes Myocardial Hypertrophy via GBP2b/GBP1 in Chronic Colitis.Circ Res202642677470PubTator, text miningPubMed
Interferon-stimulated gene signature predicts clinical response to low-dose IL-2 in immune-mediated inflammatory diseases.Ann Rheum Dis202642618420PubTator, text miningPubMed
Redistribution of peripheral blood immune cell subsets and remodeling of intercellular communication in rare Behçet's disease: a single-cell transcriptomics study.Front Med (Lausanne)202642614187PubTator, text miningPubMed
Network-guided transcriptomics identifies drug-linked host-response biomarkers in tuberculosis disease-state transition.Naunyn Schmiedebergs Arch Pharmacol202642576022PubTator, text miningPubMed
Melissa officinalis extract selectively suppresses STAT1 signaling in oral epithelial cells.Front Immunol202642540501PubTator, text miningPubMed
Multiparametric flow cytometry immune profiling of pulmonary and extra-pulmonary tuberculosis reveals distinct blood-based biomarker signatures.Tuberculosis (Edinb)202642501466PubTator, text miningPubMed
The Airway Transcriptome in Type 2 Cytokine Biomarker-High and -Low Severe Asthma.Allergy202642473711PubTator, text miningPubMed
Tumor microenvironment-oriented HNGCIscore identifies immunotherapy-sensitive subgroups in ICI retreatment of HER2-negative advanced gastric cancer.Front Oncol202642459296PubTator, text miningPubMed

1 to 10 of 1,970

See all 1,970 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2633

GET https://conductscience.org/api/genes/v1/2633/patents