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GCK: glucokinase

1 protein, 44 patents, 7 drugs, 57 trials, 3,487 NIH grants and 6,883 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGCKHGNC
NameglucokinaseHGNC
NCBI Gene ID2645NCBI Gene
HGNC IDHGNC:4195HGNC
EnsemblENSG00000106633NCBI Gene
AliasesFGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2, PNDM1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P35557Hexokinase-446535Ensembl, GeneID, HGNCUniProt

Patents 44

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026034616 A2026-02-2782P35557Espacenet
JP 2026004568 A2026-01-1447621P35557Espacenet
EP 4640849 A22025-10-291870P35557Espacenet
EP 4641201 A22025-10-2912539P35557Espacenet
JP 2025519096 A2025-06-241870P35557Espacenet
JP 2025517969 A2025-06-1212539P35557Espacenet
WO 2025096954 A12025-05-0882P35557Espacenet
JP 2025032204 A2025-03-1128927P35557Espacenet
US 12214018 B22025-02-044P35557Espacenet
EP 4461818 A22024-11-1328927P35557Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD-1656CHEMBL3219124Hexokinase type IV activatorACTIVATORChEMBL
DORZAGLIATINCHEMBL4297508Hexokinase type IV activatorACTIVATORChEMBL
LY-2608204CHEMBL4297399Hexokinase type IV activatorACTIVATORChEMBL
MK-0941CHEMBL4297302Hexokinase type IV activatorACTIVATORChEMBL
MK-0941 FREE BASECHEMBL3580737Hexokinase type IV activatorACTIVATORChEMBL
NERIGLIATINCHEMBL2165615Hexokinase type IV activatorACTIVATORChEMBL
PF-04991532CHEMBL2165620Hexokinase type IV activatorACTIVATORChEMBL

Trials 57

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06995651DORZAGLIATINPHASE1ClinicalTrials.gov
NCT06976658DORZAGLIATINPHASE2ClinicalTrials.gov
NCT06671340DORZAGLIATINClinicalTrials.gov
NCT06222476DORZAGLIATINClinicalTrials.gov
NCT05468229DORZAGLIATINPHASE1/PHASE2ClinicalTrials.gov
NCT05216172AZD-1656PHASE2ClinicalTrials.gov
NCT05098470DORZAGLIATINPHASE3ClinicalTrials.gov
NCT04531631DORZAGLIATINPHASE2ClinicalTrials.gov
NCT04516759AZD-1656PHASE22022-04-25ClinicalTrials.gov
NCT04217291LY-2608204PHASE2ClinicalTrials.gov

NIH grants 3487

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK020595Diabetes Research and Training Center492,025NIH's project files
P30DK063491Diabetes Research Center (DRC)352,025NIH's project files
P30DK019525University of Pennsylvania Diabetes Research Center342,025NIH's project files
P30DK020593Vanderbilt Diabetes Research Center262,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)252,025NIH's project files
P30DK017047Diabetes Research Center222,025NIH's project files
P30DK036836Diabetes Research Center212,025NIH's project files
ZIAHG000024Genetic analysis of type II diabetes212,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)202,025NIH's project files
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal202,025NIH's project files

Papers 6883

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824679PubTator, text miningPubMed
42824167PubTator, text miningPubMed
42823960PubTator, text miningPubMed
42806279PubTator, text miningPubMed
42791034PubTator, text miningPubMed
42785414PubTator, text miningPubMed
42772346PubTator, text miningPubMed
42769439PubTator, text miningPubMed
42745190PubTator, text miningPubMed
42677197PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license