Gene · 2646
GCKR: glucokinase regulator
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. GCKR: glucokinase regulator. Genes, record 2646. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2646
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14397 | Glucokinase regulatory protein | 625 | 18 | GeneID, HGNC |
Source UniProt
Patents3
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,296
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GCKR papers | Newest fiscal year |
|---|---|---|---|
| P30DK063491 | Diabetes Research Center (DRC) | 53 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 41 | 2025 |
| ZIAHG000024 | Genetic analysis of type II diabetes | 28 | 2025 |
| R01DK062370 | Identifying Genes for Type 2 Diabetes: FUSION | 21 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 20 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 16 | 2025 |
| UL1TR001881 | UCLA Clinical and Translational Science Institute | 16 | 2025 |
| R01DK093757 | Genetic epidemiology of rare and regulatory variants for metabolic traits | 14 | 2025 |
| U01DK061734 | Clinical Research on Nonalcoholic Fatty Liver Disease | 13 | 2025 |
| ZIAAG000965 | The Aging Genome Association Study "AGE-GAIN" | 12 | 2025 |
1 to 10 of 2,296Source NIH's project files
See all 2,296 nih grantsPapers2,346
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| PNPLA3 Is Associated With Hepatocellular Carcinoma, While a Five-Variant Polygenic Risk Score Shows Limited Discrimination in Korean Patients With MASLD. | J Gastroenterol Hepatol | 2026 | 42802015 | PubTator, text mining | PubMed |
| Polymorphic Variant Associated with Sex Hormone-Binding Globulin Level Is a Risk Factor for Preeclampsia. | Int J Mol Sci | 2026 | 42794813 | PubTator, text mining | PubMed |
| GeneSIS: enhancing transferability of polygenic scores with variant-level gene-by-sex interaction effects. | bioRxiv | 2026 | 42779975 | PubTator, text mining | PubMed |
| Ultra-rapid progression of MAFLD to cirrhosis and post-transplant steatosis in a patient with a polygenic risk profile. | MedScience | 2026 | 42758280 | PubTator, text mining | PubMed |
| Liver Fibrosis and IRS1 rs2972146 Are Associated With Weight Loss Response After Metabolic Bariatric Surgery. | Diabetes Obes Metab | 2026 | 42755140 | PubTator, text mining | PubMed |
| MBOAT7 rs641738 TT genotype is associated with poorer survival in MASLD-related hepatocellular carcinoma. | Front Oncol | 2026 | 42656337 | PubTator, text mining | PubMed |
| Beyond Fat: Reframing MASLD Through Genetics, Clonal Biology, and Precision Hepatology. | Pharmaceuticals (Basel) | 2026 | 42653643 | PubTator, text mining | PubMed |
| Purine-Metabolism Reprogramming Associated with Failed-Repair Proximal Tubule States in the AKI-to-CKD Transition. | Metabolites | 2026 | 42646274 | PubTator, text mining | PubMed |
| Elucidating the proteomic pathways linking childhood body mass index with type 2 diabetes: a Mendelian randomization and recall-by-genotype study. | Int J Epidemiol | 2026 | 42613030 | PubTator, text mining | PubMed |
| Exploring the role of inflammatory cytokines in obesity-mediated MASLD development and drug target identification. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42587048 | PubTator, text mining | PubMed |
1 to 10 of 2,346
See all 2,346 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2646
GET https://conductscience.org/api/genes/v1/2646/grants?page=2