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Gene · 26524

LATS2: large tumor suppressor kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LATS2: large tumor suppressor kinase 2. Genes, record 26524. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/26524

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Gene

Symbol
LATS2
HGNC
Name
large tumor suppressor kinase 2
HGNC
NCBI Gene ID
26524
NCBI Gene
HGNC ID
HGNC:6515
HGNC
Ensembl
ENSG00000150457
NCBI Gene
Aliases
KPM
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NRM7Serine/threonine-protein kinase LATS21,0881Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1910569Q9NRM7Espacenet
EP 4641201 A22025-10-2910927Q9NRM7Espacenet
JP 2025517969 A2025-06-1210927Q9NRM7Espacenet
JP 2025517970 A2025-06-1210569Q9NRM7Espacenet
US 12268704 B22025-04-084Q9NRM7Espacenet
JP 2024123008 A2024-09-106799Q9NRM7Espacenet
JP 2024123008 A2024-09-106800Q9NRM7Espacenet
JP 2023522784 A2023-05-31167Q9NRM7Espacenet
JP 2022188056 A2022-12-203Q9NRM7Espacenet
US 11458138 B22022-10-043Q9NRM7Espacenet

1 to 10 of 42

See all 42 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,439

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLATS2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant282025
P30CA008748Cancer Center Support Grant242025
P30DK026743UCSF Liver Center72025
P30CA036727Buffett Cancer Center Support Grant62025
R01HL118761Pitx2 in atrial fibrillation62025
P30CA006973Regional Oncology Research Center52025
P30DK034854Integrated Epithelial and Muscosal Biology52025
R01EY015708Control of Cell Number in Developing Retina52025
R01GM126048Regulation and function of the Hippo pathway in growth control52025
P30CA014051Cancer Center Support (Core) Grant42025

1 to 10 of 1,439Source NIH's project files

See all 1,439 nih grants

Papers2,966

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Comparing YAPWW1 and TAZWW: Similar Binding Sites but Different Stability and Conformational Dynamics.Biomolecules202642793187PubTator, text miningPubMed
LATS1/2 inactivation drives a distinct venous endothelial cell response that contributes to fibrotic remodeling of the lung.Sci Adv202642664350PubTator, text miningPubMed
Enzymatic activity-independent NANS stabilizes LATS2 to drive growth and therapeutic resistance in HR+/HER2- breast cancer.Nat Commun202642642385PubTator, text miningPubMed
Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harb Perspect Biol202642575696PubTator, text miningPubMed
Transcription factor activity profiling uncovers prognostic subtypes and a novel oncogenic role for PRDM4 in NSMP endometrial carcinoma.BMC Cancer202642471606PubTator, text miningPubMed
Ribosomal RNA transcription is regulated by sequestration of LATS2 and PHF6 to the nuclear speckles following DNA damage.J Cell Sci202642421490PubTator, text miningPubMed
A human iPSC model with LATS1/2 knockdown (MUSIi012-A-9) for investigating Hippo signaling in stem cell.Stem Cell Res202642378908PubTator, text miningPubMed
TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells.Nat Cell Biol202642277434PubTator, text miningPubMed
LATS2 expression differences in lung adenocarcinoma and lung squamous cell carcinoma analyzed using bioinformatics and experimental approaches.Oncol Lett202642272771PubTator, text miningPubMed
MITF maintains genome stability in nonmelanocyte lineages.Mol Oncol202642268265PubTator, text miningPubMed

1 to 10 of 2,966

See all 2,966 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/26524

GET https://conductscience.org/api/genes/v1/26524/patents?page=2