Gene · 26585
GREM1: gremlin 1, DAN family BMP antagonist
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GREM1: gremlin 1, DAN family BMP antagonist. Genes, record 26585. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/26585
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O60565 | Gremlin-1 | 184 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents186
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4705273 A2 | 2026-03-11 | 195 | O60565 | Espacenet |
| JP 2026034588 A | 2026-02-27 | 6 | O60565 | Espacenet |
| WO 2026027660 A1 | 2026-02-05 | 1 | O60565 | Espacenet |
| JP 2026004467 A | 2026-01-14 | 6 | O60565 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 19749 | O60565 | Espacenet |
| US 12473355 B2 | 2025-11-18 | 1 | O60565 | Espacenet |
| US 12458693 B2 | 2025-11-04 | 336 | O60565 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6185 | O60565 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6540 | O60565 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6540 | O60565 | Espacenet |
1 to 10 of 186
See all 186 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,887
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GREM1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 10 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 10 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 9 | 2025 |
| U01CA167551 | Colon Cancer Family Registry Cohort | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 7 | 2025 |
| P01CA196569 | Statistical Methods for Integrative Genomics in Cancer | 6 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 6 | 2025 |
| P30DK034987 | Center for Gastrointestinal Biology and Disease | 6 | 2025 |
1 to 10 of 1,887Source NIH's project files
See all 1,887 nih grantsPapers2,742
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The NOR-1/SPP1/OPN axis as a driver of abdominal aortic aneurysm. | Transl Res | 2026 | 42790627 | PubTator, text mining | PubMed |
| Allele-Specific MicroRNA-Binding Variants at Colorectal Cancer Risk Loci in a Hispanic/Latino Population: An Integrative GWAS, All of Us, and Epigenomic Analysis. | medRxiv | 2026 | 42780261 | PubTator, text mining | PubMed |
| Fibroblast-derived gremlin-1 Is associated with ovarian cancer-cell phenotypes in co-culture models. | Front Oncol | 2026 | 42769056 | PubTator, text mining | PubMed |
| Profibrogenic Gremlin-1 expression in prostate cancer and the clinicopathologic association. | Front Oncol | 2026 | 42698461 | PubTator, text mining | PubMed |
| Integrative transcriptomic and experimental analysis identifies GREM1 as a pro-metastatic mediator in lung adenocarcinoma. | J Transl Med | 2026 | 42693465 | PubTator, text mining | PubMed |
| Hunting gremlins: GREM1 as a new therapeutic target for multiple diseases including glaucoma. | Pharmacol Rev | 2026 | 42691971 | PubTator, text mining | PubMed |
| Molecular insights into uterine fibroids: crosstalk between SHH and Wnt pathways, DNA methylation, and miRNAs regulation. | Mol Genet Genomics | 2026 | 42667406 | PubTator, text mining | PubMed |
| Integrative systems-level analysis identifies potential gut microbial metabolite-host signaling networks in lung adenocarcinoma. | Comput Biol Chem | 2026 | 42641424 | PubTator, text mining | PubMed |
| Links of BMP4, BMPR1A, and GREM1 expression in subcutaneous and visceral adipose tissue with metabolic syndrome and their regulation by insulin and weight loss. | Pol Arch Intern Med | 2026 | 42639863 | PubTator, text mining | PubMed |
| Age-dependent functional and transcriptional differences in intestinal mesenchymal stromal cells during early postnatal development in piglets. | Front Cell Dev Biol | 2026 | 42614535 | PubTator, text mining | PubMed |
1 to 10 of 2,742
See all 2,742 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/26585
GET https://conductscience.org/api/genes/v1/26585/patents?page=2