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MSTN: myostatin

1 protein, 334 patents, 7 drugs, 20 trials, 2,419 NIH grants and 6,178 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMSTNHGNC
NamemyostatinHGNC
NCBI Gene ID2660NCBI Gene
HGNC IDHGNC:4223HGNC
EnsemblENSG00000138379NCBI Gene
AliasesGDF8, MSLHPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O14793Growth/differentiation factor 83755Ensembl, GeneID, HGNCUniProt

Patents 334

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4755449 A22026-06-101O14793Espacenet
EP 4755450 A22026-06-101O14793Espacenet
US 12630608 B22026-05-1935O14793Espacenet
JP 2026062645 A2026-04-10290O14793Espacenet
JP 2026505414 A2026-02-131O14793Espacenet
JP 2026004568 A2026-01-1454751O14793Espacenet
JP 2026001164 A2026-01-061O14793Espacenet
JP 2026500221 A2026-01-0645O14793Espacenet
EP 4661899 A22025-12-171O14793Espacenet
JP 2025179097 A2025-12-09297O14793Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APITEGROMABCHEMBL4594326Growth/differentiation factor 8 inhibitorINHIBITORChEMBL
DOMAGROZUMABCHEMBL3544991Growth/differentiation factor 8 inhibitorINHIBITORChEMBL
LANDOGROZUMABCHEMBL3545072Growth/differentiation factor 8 inhibitorINHIBITORChEMBL
PF-03446879CHEMBL2109522Growth/differentiation factor 8 inhibitorINHIBITORChEMBL
RAMATERCEPTCHEMBL2108674Growth/differentiation factor 8 inhibitorINHIBITORChEMBL
STAMULUMABCHEMBL2108051Growth/differentiation factor 8 inhibitorINHIBITORChEMBL
TREVOGRUMABCHEMBL3545374Growth/differentiation factor 8 inhibitorINHIBITORChEMBL

Trials 20

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07435129APITEGROMABPHASE2ClinicalTrials.gov
NCT07047144APITEGROMABPHASE2ClinicalTrials.gov
NCT06877689APITEGROMABClinicalTrials.gov
NCT06445075APITEGROMABPHASE2ClinicalTrials.gov
NCT06299098TREVOGRUMABPHASE2ClinicalTrials.gov
NCT05626855APITEGROMABPHASE3ClinicalTrials.gov
NCT05156320APITEGROMABPHASE3ClinicalTrials.gov
NCT03921528APITEGROMABPHASE22022-11-17ClinicalTrials.gov
NCT03710941TREVOGRUMABPHASE2ClinicalTrials.gov
NCT02943239TREVOGRUMABPHASE1ClinicalTrials.gov

NIH grants 2419

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U01DK061732Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Clinical Center-Cleveland site182,025NIH's project files
P30AG024832UTMB Claude D. Pepper Older Americans Independence Center142,025NIH's project files
P30AG028740University of Florida Older Americans Independence Center (OAIC)132,025NIH's project files
P50AA024333Alcohol and tissue injury, from mechanisms to treatments132,025NIH's project files
P30AG031679Boston OAIC: A Translational Approach to Function Promoting Therapies112,025NIH's project files
P30CA008748Cancer Center Support Grant102,025NIH's project files
P30CA082709Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant82,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)82,025NIH's project files
P30DK056341Washington University Nutrition Obesity Research Center82,025NIH's project files
P01AG036675Kynurenine accumulation drives loss of muscle and bone function with aging72,025NIH's project files

Papers 6178

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816254PubTator, text miningPubMed
42813516PubTator, text miningPubMed
42804367PubTator, text miningPubMed
42792823PubTator, text miningPubMed
42783791PubTator, text miningPubMed
42777178PubTator, text miningPubMed
42773997PubTator, text miningPubMed
42769337PubTator, text miningPubMed
42760382PubTator, text miningPubMed
42756850PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license