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GDNF: glial cell derived neurotrophic factor

1 protein, 182 patents, 0 drugs, 0 trials, 7,678 NIH grants and 14,796 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGDNFHGNC
Nameglial cell derived neurotrophic factorHGNC
NCBI Gene ID2668NCBI Gene
HGNC IDHGNC:4232HGNC
EnsemblENSG00000168621NCBI Gene
AliasesATF, ATF1, ATF2, HFB1-GDNF, HSCR3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P39905Glial cell line-derived neurotrophic factor2114Ensembl, GeneID, HGNCUniProt

Patents 182

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4795179 A12026-08-26188P39905Espacenet
EP 4782462 A22026-07-291P39905Espacenet
EP 4770680 A12026-07-0820P39905Espacenet
JP 2026517854 A2026-06-026P39905Espacenet
US 12605467 B22026-04-2134P39905Espacenet
JP 2026053560 A2026-03-254P39905Espacenet
EP 4704920 A12026-03-11139P39905Espacenet
EP 4650780 A22025-11-195093P39905Espacenet
JP 2025169942 A2025-11-141001P39905Espacenet
JP 2025147176 A2025-10-065869P39905Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 7678

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant452,025NIH's project files
P30CA016672Cancer Center Support Grant262,025NIH's project files
R01AG013730Compromised LDH activity causes motor deficits and hastens ALS progression192,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)162,025NIH's project files
R01NS034239Neuroprotective Immunity and HIV Dementia112,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award112,025NIH's project files
P01CA100730Retrovirus Models of Cancer102,025NIH's project files
P30CA086862Cancer Center Support Grant92,025NIH's project files
P30CA091842Cancer Center Support Grant92,025NIH's project files
P51OD011106Wisconsin National Primate Research Center Support92,025NIH's project files

Papers 14796

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826913PubTator, text miningPubMed
42818447PubTator, text miningPubMed
42800594PubTator, text miningPubMed
42799794PubTator, text miningPubMed
42795766PubTator, text miningPubMed
42783242PubTator, text miningPubMed
42773379PubTator, text miningPubMed
42752555PubTator, text miningPubMed
42735573PubTator, text miningPubMed
42731765PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license