ConductScience.org, home

Gene · 2674

GFRA1: GDNF family receptor alpha 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. GFRA1: GDNF family receptor alpha 1. Genes, record 2674. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2674

On this page

Gene

Symbol
GFRA1
HGNC
Name
GDNF family receptor alpha 1
HGNC
NCBI Gene ID
2674
NCBI Gene
HGNC ID
HGNC:4243
HGNC
Ensembl
ENSG00000151892
NCBI Gene
Aliases
GDNFR, GDNFR-alpha-1, GDNFRA, GFR-ALPHA-1, GFRalpha-1, RET1L, RETL1, RHDA4, TRNR1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P56159GDNF family receptor alpha-14651Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447426P56159Espacenet
EP 4650780 A22025-11-197167P56159Espacenet
EP 4641201 A22025-10-297083P56159Espacenet
JP 2025533979 A2025-10-091P56159Espacenet
JP 2025529142 A2025-09-041696P56159Espacenet
JP 2025525078 A2025-08-011P56159Espacenet
JP 2025525081 A2025-08-011P56159Espacenet
US 12371689 B22025-07-291696P56159Espacenet
WO 2025133191 A12025-06-261P56159Espacenet
JP 2025517969 A2025-06-127083P56159Espacenet

1 to 10 of 51

See all 51 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
LIATERMINCHEMBL2108380GDNF family receptor alpha-1 agonistAGONIST

Source ChEMBL

Trials2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00115427LIATERMINPHASE1ClinicalTrials.gov
NCT00111982LIATERMINPHASE1/PHASE2ClinicalTrials.gov

NIH grants1,177

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGFRA1 papersNewest fiscal year
R01AG013730Compromised LDH activity causes motor deficits and hastens ALS progression112025
P30CA008748Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
P50HD096723Genetics of Male Infertility: Accelerating the pace of discovery42025
P30AI027767UAB Center for AIDS Research (CFAR)32025
P30CA016058Cancer Center Support Grant32025
P30CA042014Cancer Center Support Grant32025
P30CA054174Mays Cancer Center at UT Health SA32025
P30CA068485Cancer Center Support Grant32025

1 to 10 of 1,177Source NIH's project files

See all 1,177 nih grants

Papers1,736

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Conformational switching and spatial heterogeneity: Decoding SERPINE1/PAI-1as a multifaceted driver of tumor progression and therapy resistance.Crit Rev Oncol Hematol202642826913PubTator, text miningPubMed
Candidate biomarkers in narcolepsy in H1N1-vaccinated cohorts: A proteomic and transcriptomic study.Sleep Med202642748496PubTator, text miningPubMed
APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease.Nat Genet202642736378PubTator, text miningPubMed
Reduced mechanical shear is associated with early cortical differentiation and GDNF-GFRA1/RET signalling in human brain organoids.Stem Cells Transl Med202642710856PubTator, text miningPubMed
A cerebrospinal fluid blood-brain barrier dysfunction score is associated with progression from mild cognitive impairment to Alzheimer's disease.Neurol Sci202642635841PubTator, text miningPubMed
AID-Mediated Protein Knockdown Reveals the Requirement of NANOS2 in Prenatal Gonocytes for Establishing Functional Spermatogonial Stem Cells.Dev Growth Differ202642543487PubTator, text miningPubMed
Dysregulation of GDNF and GFRα1 expression in multifactorial Hirschsprung disease.BMC Res Notes202642321920PubTator, text miningPubMed
A long-chain heparan sulfate capture mechanism directs paracrine GDNF-GFRα1 signalling through RET.bioRxiv202642239124PubTator, text miningPubMed
Predictive epigenetic biomarkers of successful weight-loss intervention in pre-pubertal children with obesity.Clin Epigenetics202642210364PubTator, text miningPubMed
Converging neurotrophic-immune signaling in autism spectrum disorder: integrative roles of klotho, GDNF/GFRA-1, IGF-1 and GLP-1 pathways.Metab Brain Dis202642154377PubTator, text miningPubMed

1 to 10 of 1,736

See all 1,736 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2674

GET https://conductscience.org/api/genes/v1/2674/patents?page=2