Gene · 2677
GGCX: gamma-glutamyl carboxylase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GGCX: gamma-glutamyl carboxylase. Genes, record 2677. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2677
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P38435 | Vitamin K-dependent gamma-carboxylase | 758 | 29 | Ensembl, GeneID, HGNC |
Source UniProt
Patents36
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47287 | P38435 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 867 | P38435 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 101 | P38435 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 612 | P38435 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1699 | P38435 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1699 | P38435 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 101 | P38435 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 612 | P38435 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 867 | P38435 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 34021 | P38435 | Espacenet |
1 to 10 of 36
See all 36 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| ANISINDIONE | CHEMBL712 | Vitamin K-dependent gamma-carboxylase inhibitor | INHIBITOR |
Source ChEMBL
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants544
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GGCX papers | Newest fiscal year |
|---|---|---|---|
| R01GM131008 | NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID MEMBRANES AND CELLS | 7 | 2025 |
| R01HL121718 | Structural and Functional Basis of the Vitamin K Cycle | 7 | 2025 |
| T32GM007569 | Clinical Pharmacology Training Program | 4 | 2025 |
| R01AI158500 | Defining the partner interaction network of the tetraspanin CD53 in regulating B cell trafficking | 3 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
| K24HL133373 | Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy | 2 | 2025 |
| P01AI063302 | The intersection of innate and adaptive immunity to intracellular pathogens | 2 | 2025 |
| P20GM113134 | COBRE-DIABETES | 2 | 2025 |
| P30AG066444 | Alzheimer's Disease Research Center | 2 | 2025 |
| P30ES007033 | University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment | 2 | 2025 |
1 to 10 of 544Source NIH's project files
See all 544 nih grantsPapers892
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Post-translational control of MAVS signaling: linking mitochondrial antiviral immunity to metabolic and cellular stress contexts. | Front Physiol | 2026 | 42719470 | PubTator, text mining | PubMed |
| Comparison of predicted C-peptide structures of human and venom insulin G1: A putative γ-glutamyl carboxylase recognition motif in venom insulin. | Toxicon | 2026 | 42705356 | PubTator, text mining | PubMed |
| γ-glutamyl carboxylase inhibition by Anisindione. | Structure | 2026 | 42660115 | PubTator, text mining | PubMed |
| Molecular-Genetic Basis of Pulmonary Arterial Hypertension (PAH). | Curr Issues Mol Biol | 2026 | 42353577 | PubTator, text mining | PubMed |
| Structural basis for the carboxylation and epoxidation of human gamma-glutamyl carboxylase. | Nat Commun | 2026 | 41888148 | PubTator, text mining | PubMed |
| Expanding the genetic burden of low-evidence genes in pulmonary arterial hypertension. | Eur J Hum Genet | 2026 | 41882294 | PubTator, text mining | PubMed |
| Bioengineered baculovirus-derived extracellular vesicles loaded with of γ-carboxylated Gla-rich protein: Dual modulation of inflammation and vascular calcification. | Biomater Adv | 2026 | 41861711 | PubTator, text mining | PubMed |
| Microbial biofortification of fermented foods: a review of probiotic-mediated nutrient enhancement. | Front Nutr | 2026 | 41769659 | PubTator, text mining | PubMed |
| An Overview of Anticoagulant Drugs Pharmacology, Therapeutic Approaches, Limitations and Perspectives. | Pharmaceutics | 2026 | 41754906 | PubTator, text mining | PubMed |
| Vitamin K Prophylaxis in Newborns: A Narrative Review of the Molecular Basis, Clinical Evidence, and Comparative Effectiveness of Intramuscular Versus Oral Administration and Parental Hesitation. | Int J Mol Sci | 2026 | 41751806 | PubTator, text mining | PubMed |
1 to 10 of 892
See all 892 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2677
GET https://conductscience.org/api/genes/v1/2677/patents?page=2