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Gene · 2677

GGCX: gamma-glutamyl carboxylase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GGCX: gamma-glutamyl carboxylase. Genes, record 2677. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2677

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Gene

Symbol
GGCX
HGNC
Name
gamma-glutamyl carboxylase
HGNC
NCBI Gene ID
2677
NCBI Gene
HGNC ID
HGNC:4247
HGNC
Ensembl
ENSG00000115486
NCBI Gene
Aliases
VKCFD1, VKGC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P38435Vitamin K-dependent gamma-carboxylase75829Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447287P38435Espacenet
EP 4650780 A22025-11-19867P38435Espacenet
EP 4640849 A22025-10-29101P38435Espacenet
EP 4641201 A22025-10-29612P38435Espacenet
JP 2025529142 A2025-09-041699P38435Espacenet
US 12371689 B22025-07-291699P38435Espacenet
JP 2025519096 A2025-06-24101P38435Espacenet
JP 2025517969 A2025-06-12612P38435Espacenet
JP 2025517970 A2025-06-12867P38435Espacenet
US 11446398 B22022-09-2034021P38435Espacenet

1 to 10 of 36

See all 36 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ANISINDIONECHEMBL712Vitamin K-dependent gamma-carboxylase inhibitorINHIBITOR

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants544

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGGCX papersNewest fiscal year
R01GM131008NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID MEMBRANES AND CELLS72025
R01HL121718Structural and Functional Basis of the Vitamin K Cycle72025
T32GM007569Clinical Pharmacology Training Program42025
R01AI158500Defining the partner interaction network of the tetraspanin CD53 in regulating B cell trafficking32025
UL1TR001863Yale Clinical and Translational Science Award32025
K24HL133373Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy22025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens22025
P20GM113134COBRE-DIABETES22025
P30AG066444Alzheimer's Disease Research Center22025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment22025

1 to 10 of 544Source NIH's project files

See all 544 nih grants

Papers892

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Post-translational control of MAVS signaling: linking mitochondrial antiviral immunity to metabolic and cellular stress contexts.Front Physiol202642719470PubTator, text miningPubMed
Comparison of predicted C-peptide structures of human and venom insulin G1: A putative γ-glutamyl carboxylase recognition motif in venom insulin.Toxicon202642705356PubTator, text miningPubMed
γ-glutamyl carboxylase inhibition by Anisindione.Structure202642660115PubTator, text miningPubMed
Molecular-Genetic Basis of Pulmonary Arterial Hypertension (PAH).Curr Issues Mol Biol202642353577PubTator, text miningPubMed
Structural basis for the carboxylation and epoxidation of human gamma-glutamyl carboxylase.Nat Commun202641888148PubTator, text miningPubMed
Expanding the genetic burden of low-evidence genes in pulmonary arterial hypertension.Eur J Hum Genet202641882294PubTator, text miningPubMed
Bioengineered baculovirus-derived extracellular vesicles loaded with of γ-carboxylated Gla-rich protein: Dual modulation of inflammation and vascular calcification.Biomater Adv202641861711PubTator, text miningPubMed
Microbial biofortification of fermented foods: a review of probiotic-mediated nutrient enhancement.Front Nutr202641769659PubTator, text miningPubMed
An Overview of Anticoagulant Drugs Pharmacology, Therapeutic Approaches, Limitations and Perspectives.Pharmaceutics202641754906PubTator, text miningPubMed
Vitamin K Prophylaxis in Newborns: A Narrative Review of the Molecular Basis, Clinical Evidence, and Comparative Effectiveness of Intramuscular Versus Oral Administration and Parental Hesitation.Int J Mol Sci202641751806PubTator, text miningPubMed

1 to 10 of 892

See all 892 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2677

GET https://conductscience.org/api/genes/v1/2677/patents?page=2