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GHR: growth hormone receptor

1 protein, 119 patents, 6 drugs, 261 trials, 2,342 NIH grants and 5,521 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGHRHGNC
Namegrowth hormone receptorHGNC
NCBI Gene ID2690NCBI Gene
HGNC IDHGNC:4263HGNC
EnsemblENSG00000112964NCBI Gene
AliasesGHBP, GHIPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P10912Growth hormone receptor63811Ensembl, GeneID, HGNCUniProt

Patents 119

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026120541 A2026-07-2284P10912Espacenet
JP 2026082857 A2026-05-1984P10912Espacenet
JP 2026004568 A2026-01-1448345P10912Espacenet
EP 4650780 A22025-11-19782P10912Espacenet
EP 4641201 A22025-10-29554P10912Espacenet
EP 4633648 A12025-10-2246P10912Espacenet
JP 2025529142 A2025-09-041704P10912Espacenet
US 12371689 B22025-07-291704P10912Espacenet
JP 2025517969 A2025-06-12554P10912Espacenet
JP 2025517970 A2025-06-12782P10912Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LONAPEGSOMATROPINCHEMBL4298185Growth hormone receptor agonistAGONISTChEMBL
PEGVISOMANTCHEMBL1201515Growth hormone receptor antagonistANTAGONISTChEMBL
SOMAPACITANCHEMBL3707290Growth hormone receptor agonistAGONISTChEMBL
SOMATREMCHEMBL1201620Growth hormone receptor agonistAGONISTChEMBL
SOMATROGONCHEMBL4297830Growth hormone receptor agonistAGONISTChEMBL
SOMATROPINCHEMBL1201621Growth hormone receptor agonistAGONISTChEMBL

Trials 261

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07359625SOMATROPINClinicalTrials.gov
NCT07323329SOMATROPINPHASE2/PHASE3ClinicalTrials.gov
NCT07309562SOMATROPINPHASE3ClinicalTrials.gov
NCT07260500SOMATROPINPHASE2ClinicalTrials.gov
NCT07226089SOMATROPINPHASE3ClinicalTrials.gov
NCT07226089SOMATROGONPHASE3ClinicalTrials.gov
NCT07221851SOMATROPINPHASE3ClinicalTrials.gov
NCT07221851LONAPEGSOMATROPINPHASE3ClinicalTrials.gov
NCT07036003SOMATROPINPHASE1/PHASE2ClinicalTrials.gov
NCT06907121SOMATROPINPHASE2/PHASE3ClinicalTrials.gov

NIH grants 2342

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01AG059779Combining GHR antagonism with life extending compounds: a search for synergies242,025NIH's project files
R01DK113998Mechanisms for GH action on epithelial cells112,025NIH's project files
P30CA016672Cancer Center Support Grant102,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)102,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)92,025NIH's project files
P01AG047200Comparative genomics of longevity and Alzheimer's disease82,025NIH's project files
P30DK036836Diabetes Research Center82,025NIH's project files
P30AG024824Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center)72,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)72,025NIH's project files
U19AG023122Longevity Consortium72,025NIH's project files

Papers 5521

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42776131PubTator, text miningPubMed
42705172PubTator, text miningPubMed
42694310PubTator, text miningPubMed
42664975PubTator, text miningPubMed
42660265PubTator, text miningPubMed
42652933PubTator, text miningPubMed
42628320PubTator, text miningPubMed
42589503PubTator, text miningPubMed
42573163PubTator, text miningPubMed
42557589PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license