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Gene · 2702

GJA5: gap junction protein alpha 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GJA5: gap junction protein alpha 5. Genes, record 2702. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2702

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Gene

Symbol
GJA5
HGNC
Name
gap junction protein alpha 5
HGNC
NCBI Gene ID
2702
NCBI Gene
HGNC ID
HGNC:4279
HGNC
Ensembl
ENSG00000265107
NCBI Gene
Aliases
ATFB11, CX40
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P36382Gap junction alpha-5 protein3580Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447343P36382Espacenet
JP 2026004568 A2026-01-1447344P36382Espacenet
JP 2025509296 A2025-04-11119P36382Espacenet
EP 4490268 A12025-01-15119P36382Espacenet
US 11959097 B22024-04-16119P36382Espacenet
US 11446398 B22022-09-2034113P36382Espacenet
US 11446398 B22022-09-2034114P36382Espacenet
US 11400116 B22022-08-023242P36382Espacenet
US 11400116 B22022-08-026622P36382Espacenet
JP 2022524081 A2022-04-27137084P36382Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,513

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGJA5 papersNewest fiscal year
R01GM072631Mechanisms of Gap Junction Regulation122025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL122025
R01HL135109Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation72025
R01EY012085Intercellular Communication in the Eye Lens52025
R01HL130020Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs52025
R01HL141371Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated Cardiomyopathy52025
T32HL007249Interdisciplinary Training in Cardiovascular Research52025
P30CA036727Buffett Cancer Center Support Grant42025
R01HL076485Engineering Vascularized Cardiac Muscle42025
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation42025

1 to 10 of 1,513Source NIH's project files

See all 1,513 nih grants

Papers2,310

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities.Front Cell Neurosci202642819782PubTator, text miningPubMed
Immune escape in portal vein tumor thrombus: an intravascular tumor-immune niche framework for hepatocellular carcinoma.Front Immunol202642819771PubTator, text miningPubMed
Genetic loci responsible for atrioventricular block in children.Front Cell Dev Biol202642798645PubTator, text miningPubMed
Twist1 Promotes Endothelial Phenotypic Transition and Unstable Plaque Phenotype During Atherosclerosis.Arterioscler Thromb Vasc Biol202642689320PubTator, text miningPubMed
In vitro generation of human embryonic stem cell-derived heart organoids possessing physiological ion currents.Regen Ther202642395059PubTator, text miningPubMed
The Genetics of Atrial Fibrillation: From Molecular Mechanisms to Precision Medicine.Cureus202642371450PubTator, text miningPubMed
Current Topics of Progressive Cardiac Conduction Disease.J Arrhythm202642368294PubTator, text miningPubMed
miRNA-26b Is Associated with Increased Connexin-40 Expression in Endothelial Cells Under Flow Conditions.Int J Mol Sci202642196619PubTator, text miningPubMed
Transcriptional coordination in multicellular lineage differentiation during lung organogenesis: deciphering the role of epithelial cells as a microenvironmental regulatory hub.Front Cell Dev Biol202641799436PubTator, text miningPubMed
Effectiveness of warm acupuncture and moxibustion in the treatment of osteoarthritis: a retrospective study on clinical and molecular outcomes.Front Med (Lausanne)202641789011PubTator, text miningPubMed

1 to 10 of 2,310

See all 2,310 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2702

GET https://conductscience.org/api/genes/v1/2702/patents?page=2