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Gene · 27036

SIGLEC7: sialic acid binding Ig like lectin 7

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SIGLEC7: sialic acid binding Ig like lectin 7. Genes, record 27036. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27036

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Gene

Symbol
SIGLEC7
HGNC
Name
sialic acid binding Ig like lectin 7
HGNC
NCBI Gene ID
27036
NCBI Gene
HGNC ID
HGNC:10876
HGNC
Ensembl
ENSG00000168995
NCBI Gene
Aliases
AIRM-1, AIRM1, CD328, CDw328, D-siglec, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y286Sialic acid-binding Ig-like lectin 74676Ensembl, GeneID, HGNC

Source UniProt

Patents77

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463511Q9Y286Espacenet
EP 4650780 A22025-11-195488Q9Y286Espacenet
EP 4641201 A22025-10-295101Q9Y286Espacenet
JP 2025147176 A2025-10-0612273Q9Y286Espacenet
EP 4619424 A22025-09-24100Q9Y286Espacenet
JP 2025529142 A2025-09-043961Q9Y286Espacenet
JP 2025529142 A2025-09-047718Q9Y286Espacenet
US 12371689 B22025-07-293961Q9Y286Espacenet
US 12371689 B22025-07-297718Q9Y286Espacenet
JP 2025517969 A2025-06-125101Q9Y286Espacenet

1 to 10 of 77

See all 77 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,469

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSIGLEC7 papersNewest fiscal year
R01CA227942Targeting the cancer glycocalyx122025
P30CA016520Abramson Cancer Center Support Grant92025
P30AI045008Penn Center for AIDS Research82025
P30CA008748Cancer Center Support Grant82025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies72025
P30AI027763UCSF-Bay Area Center for AIDS Research72025
U19AI070535Airway Inflammation and Airway Remodeling in Severe Asthma72025
P30CA016672Cancer Center Support Grant62025
R01HL118979Enhancing Treg Therapeutic Efficacy in GVHD62025
P30CA010815Consolidated Basic Cancer Research Program52025

1 to 10 of 1,469Source NIH's project files

See all 1,469 nih grants

Papers1,589

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Siglec-7 orchestrates mitochondrial dynamics and metabolic reprogramming to restrain human NK cell cytotoxic function.J Biol Chem202642710663PubTator, text miningPubMed
Loss of ST8SIA6 is associated with enhanced MUC16-Integrin β4 signaling and aggressive phenotypes in colorectal cancer.Biochem Biophys Rep202642698897PubTator, text miningPubMed
Persistent Cytotoxic Immune Signaling in Anti-VEGF-Treated Neovascular Age-Related Macular Degeneration.medRxiv202642643214PubTator, text miningPubMed
FOS regulation of T-cell activation and the mechanism of inflammatory injury of coronary endothelium in Kawasaki disease.Transl Pediatr202642433922PubTator, text miningPubMed
Nectin-4 as predictive biomarker of immune-related adverse event subtypes in adjuvant anti-programmed-death-1 treatment of melanoma.Melanoma Res202642421561PubTator, text miningPubMed
Prediction of Novel Disease-Related Regions in SIGLEC-7 by In Silico and Biochemical Analyses.Int J Mol Sci202642353205PubTator, text miningPubMed
Patient-derived organotypic tumor spheroids as a functional platform for predicting immunotherapeutic responses and guiding precision treatment for hepatocellular carcinoma.J Immunother Cancer202642082269PubTator, text miningPubMed
Abnormal glycosylation of MUC20 mediates TAM polarization and promotes immune escape in colorectal cancer.Commun Biol202641965932PubTator, text miningPubMed
Targeting ST3GAL1 to downregulate ligands for the glycoimmune checkpoint Siglec-7 and reverse immune escape in hepatocellular carcinoma.Cancer Immunol Immunother202641961075PubTator, text miningPubMed
Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity.Science202641955354PubTator, text miningPubMed

1 to 10 of 1,589

See all 1,589 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/27036

GET https://conductscience.org/api/genes/v1/27036/patents?page=2