Gene · 27040
LAT: linker for activation of T cells
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. LAT: linker for activation of T cells. Genes, record 27040. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27040
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43561 | Linker for activation of T-cells family member 1 | 262 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents42
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 51807 | O43561 | Espacenet |
| WO 2025252547 A1 | 2025-12-11 | 60 | O43561 | Espacenet |
| EP 4660322 A1 | 2025-12-10 | 60 | O43561 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 7713 | O43561 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16545 | O43561 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 7713 | O43561 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 16545 | O43561 | Espacenet |
| US 12215347 B2 | 2025-02-04 | 8 | O43561 | Espacenet |
| WO 2025016918 A1 | 2025-01-23 | 60 | O43561 | Espacenet |
| EP 4495265 A1 | 2025-01-22 | 60 | O43561 | Espacenet |
1 to 10 of 42
See all 42 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,211
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LAT papers | Newest fiscal year |
|---|---|---|---|
| P01AI091580 | Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR | 46 | 2025 |
| ZIABC010304 | Biochemical Basis of T Cell Activation | 44 | 2025 |
| ZICBC010978 | Confocal Core for the Laboratory of Cellular and Molecular Biology | 15 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 14 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 14 | 2025 |
| T32AI007485 | Predoctoral Training Program in Immunology | 12 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| ZIAHD001803 | Genes and signals controlling mammalian hematopoiesis. | 8 | 2025 |
| U19AI057266 | Vaccine and Infection Induced Immunity in the Young and Aged | 6 | 2025 |
| P30EY008098 | Core Grant for Vision Research | 5 | 2025 |
1 to 10 of 2,211Source NIH's project files
See all 2,211 nih grantsPapers3,321
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| LAT condensation gates PLCγ1 activation via bimodal LAT phosphorylation. | Proc Natl Acad Sci U S A | 2026 | 42814554 | PubTator, text mining | PubMed |
| Anti-CD6 monoclonal antibody UMCD6 induces CD6 internalization, remodels costimulatory receptor availability, and modulates CD4+ T-cell activation. | Front Immunol | 2026 | 42688261 | PubTator, text mining | PubMed |
| Antibody Fc receptor CD16a mediates natural killer cell activation via mechanotransduction of piconewton forces. | Sci Adv | 2026 | 42664362 | PubTator, text mining | PubMed |
| Making the Case for Organ-on-Chip Platforms in Long-Acting Therapeutics Development. | Adv Healthc Mater | 2026 | 42629977 | PubTator, text mining | PubMed |
| Dietary supplementation of lysolecithin improves growth performance of piglets fed a low-nutrient density diet by modulating nutrient utilization and metabolism. | Anim Nutr | 2026 | 42602500 | PubTator, text mining | PubMed |
| Bioinformatics-driven discovery and experimental validation of differentially expressed genes in colorectal adenomas. | Mol Biol Rep | 2026 | 42517945 | PubTator, text mining | PubMed |
| Cerebrospinal Fluid Transcriptional Immune Pathways Linked to Survival in HIV-Associated Tuberculous Meningitis. | J Infect Dis | 2026 | 42313402 | PubTator, text mining | PubMed |
| Species differences influencing the safety assessment of CD3 T-cell engagers. | J Immunotoxicol | 2026 | 42287728 | PubTator, text mining | PubMed |
| A whole genomic CRISPR-Cas9 screen identifies the amino acid transporter SLC43A1 (LAT3) as a major determinant of oxaliplatin sensitivity in colorectal cancer cells. | Mol Cancer Ther | 2026 | 42227585 | PubTator, text mining | PubMed |
| Type 1 Diabetes and Multiple Sclerosis Share General Autoimmunity Genetic Variation. | Genes (Basel) | 2026 | 42194988 | PubTator, text mining | PubMed |
1 to 10 of 3,321
See all 3,321 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/27040
GET https://conductscience.org/api/genes/v1/27040/patents?page=2