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GJB2: gap junction protein beta 2

1 protein, 80 patents, 0 drugs, 0 trials, 1,711 NIH grants and 5,717 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGJB2HGNC
Namegap junction protein beta 2HGNC
NCBI Gene ID2706NCBI Gene
HGNC IDHGNC:4284HGNC
EnsemblENSG00000165474NCBI Gene
AliasesBAPS, CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPKNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29033Gap junction beta-2 protein22624Ensembl, GeneID, HGNCUniProt

Patents 80

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082974 A2026-05-19122P29033Espacenet
JP 2026514375 A2026-05-111P29033Espacenet
EP 4713463 A12026-03-2529P29033Espacenet
JP 2026004568 A2026-01-1447355P29033Espacenet
JP 2026004568 A2026-01-1447356P29033Espacenet
KR 1020250175321 A2025-12-161P29033Espacenet
EP 4641202 A22025-10-29606P29033Espacenet
JP 2025163105 A2025-10-287P29033Espacenet
JP 2025529142 A2025-09-041719P29033Espacenet
JP 2025110904 A2025-07-2919P29033Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 1711

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DC003594Identification of Autosomal Recessive Nonsyndromic Hearing Impairment Genes302,025NIH's project files
R01DC012049Optimizing Genetic Testing for Deafness for Clinical Diagnostics272,025NIH's project files
R01DC009645A Collaborative Search for New Genes for Non-Syndromic Deafness192,025NIH's project files
ZIADC000039Identification of Genes Causing Syndromic and Nonsyndromic Hearing Impairment132,025NIH's project files
ZIADC000048Functional Studies of "Deafness Genes" Essential for Hearing102,025NIH's project files
R01GM099490Gating and Regulation of Connexin Hemichannels92,025NIH's project files
T32DC000040Research Training Program in Otolaryngology92,025NIH's project files
R01GM072631Mechanisms of Gap Junction Regulation82,025NIH's project files
P30CA016672Cancer Center Support Grant72,025NIH's project files
ZICDC000086Genomic and Computational Biology Support for NIDCD Intramural Research72,025NIH's project files

Papers 5717

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42815004PubTator, text miningPubMed
42794199PubTator, text miningPubMed
42774553PubTator, text miningPubMed
42764263PubTator, text miningPubMed
42746537PubTator, text miningPubMed
42722797PubTator, text miningPubMed
42702049PubTator, text miningPubMed
42689374PubTator, text miningPubMed
42684354PubTator, text miningPubMed
42656996PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license