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EIF2AK1: eukaryotic translation initiation factor 2 alpha kinase 1
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Gene · 27102

Papers1,395

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 1,395

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TitleJournalYearPMIDFound bySource
Integrated stress response activation in combination PG3 and cisplatin-treated TP53-mutated head and neck squamous carcinoma cells induces potent apoptotic response.bioRxiv202642818268PubTator, text miningPubMed
Mitochondrial complex I and II inhibiting pesticides activate DELE1-HRI integrated stress signaling but engage distinct cell death programs in human neuronal cells.Toxicol Appl Pharmacol202642594974PubTator, text miningPubMed
An ancient mitochondrial program tunes translation to haem availability.Nature202642557333PubTator, text miningPubMed
EIF2AK1 As a Key Genetic Determinant of Luspatercept Resistance in Transfusion-Dependent Thalassemia.Am J Hematol202642403074PubTator, text miningPubMed
Metformin Partially Attenuates Simvastatin-Induced Myotoxic Responses in C2C12 Myotubes Through Metabolic Adaptation.FASEB J202642361123PubTator, text miningPubMed
Regulatory mechanism of heme-regulated inhibitor through autophosphorylation-driven activation and heme-induced deactivation.J Biochem202642350899PubTator, text miningPubMed
Mitochondrial integrated stress response activation creates a therapeutic vulnerability to MCL-1 inhibition in acute myeloid leukemia.Cell Death Dis202642350371PubTator, text miningPubMed
Understanding the OMA1-DELE1-HRI Axis and PINK1-parkin-mediated Mitophagy in Parkinson's Disease.CNS Neurol Disord Drug Targets202642261169PubTator, text miningPubMed
Iron: Regulation, redox homeostasis, and ferroptosis in cancer.Ferroptosis Oxid Stress202642099806PubTator, text miningPubMed
The integrated stress response in cancer: mechanisms of tumor adaptation and therapeutic targeting.Biochem Soc Trans202642043015PubTator, text miningPubMed
The heme-regulated inhibitor eIF2α kinase: a multifaceted sensor and drug target.Trends Cell Biol202641991349PubTator, text miningPubMed
Overcoming immunotherapy resistance in breast cancer: a novel strategy by targeting the integrated stress response.Front Cell Dev Biol202641938533PubTator, text miningPubMed
Stress granules at the crossroads of retroviral replication and antiviral immunity: mechanisms and therapeutic opportunities.Mol Biol Rep202641931190PubTator, text miningPubMed
Tumor metabolic plasticity in therapy resistance: from the Warburg effect to mitochondrial hijacking.Theranostics202641799204PubTator, text miningPubMed
A Cross-Species Hydroquinone Model Replicates Smoking-Related Corneal Endothelial Oxidative Injury and Enables Therapeutic Screening of FGF10.Invest Ophthalmol Vis Sci202641789845PubTator, text miningPubMed
The Yin-Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease.Biocell202641777532PubTator, text miningPubMed
Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants.bioRxiv202641756847PubTator, text miningPubMed
RNA-Seq of Gingival Fibroblasts Grown on Collagen Membranes and Hyaluronic Acid.J Funct Biomater202641745519PubTator, text miningPubMed
Pharmacological induction of mitochondrial stress counteracts therapy resistance in glioblastoma stem-like cells.bioRxiv202641727106PubTator, text miningPubMed
De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response.bioRxiv202641717097PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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