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Gene · 27102

EIF2AK1: eukaryotic translation initiation factor 2 alpha kinase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EIF2AK1: eukaryotic translation initiation factor 2 alpha kinase 1. Genes, record 27102. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27102

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Gene

Symbol
EIF2AK1
HGNC
Name
eukaryotic translation initiation factor 2 alpha kinase 1
HGNC
NCBI Gene ID
27102
NCBI Gene
HGNC ID
HGNC:24921
HGNC
Ensembl
ENSG00000086232
NCBI Gene
Aliases
HCR, HRI, KIAA1369, hHRI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9BQI3Eukaryotic translation initiation factor 2-alpha kinase 16300Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445464Q9BQI3Espacenet
EP 4650780 A22025-11-19199Q9BQI3Espacenet
EP 4641201 A22025-10-29166Q9BQI3Espacenet
JP 2025147176 A2025-10-064669Q9BQI3Espacenet
JP 2025529142 A2025-09-046246Q9BQI3Espacenet
US 12371689 B22025-07-296246Q9BQI3Espacenet
JP 2025517969 A2025-06-12166Q9BQI3Espacenet
JP 2025517970 A2025-06-12199Q9BQI3Espacenet
JP 2025028160 A2025-02-284669Q9BQI3Espacenet
KR 1020250010750 A2025-01-214669Q9BQI3Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,150

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEIF2AK1 papersNewest fiscal year
R01NS095892IMPACTING MITOCHONDRIAL FUNCTION THROUGH ALTERED PROTEASE ACTIVITY82025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant42025
R01HL119479Regulation of Hemoglobin Switching42025
F30AG081061Alleviating Mitochondrial Dysfunction in PERK-deficient Neurodegenerative Disease32025
P30CA008748Cancer Center Support Grant32025
P30CA021765Cancer Center Support Grant (CCSG)32025
R01DK060596Translational control by nutrients32025
T32CA009594Multi-Disciplinary Training Grant in Cancer Research32025
ZIAHD001010Mechanism and Regulation of Eukaryotic Protein Synthesis32025

1 to 10 of 1,150Source NIH's project files

See all 1,150 nih grants

Papers1,395

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated stress response activation in combination PG3 and cisplatin-treated TP53-mutated head and neck squamous carcinoma cells induces potent apoptotic response.bioRxiv202642818268PubTator, text miningPubMed
Mitochondrial complex I and II inhibiting pesticides activate DELE1-HRI integrated stress signaling but engage distinct cell death programs in human neuronal cells.Toxicol Appl Pharmacol202642594974PubTator, text miningPubMed
An ancient mitochondrial program tunes translation to haem availability.Nature202642557333PubTator, text miningPubMed
EIF2AK1 As a Key Genetic Determinant of Luspatercept Resistance in Transfusion-Dependent Thalassemia.Am J Hematol202642403074PubTator, text miningPubMed
Metformin Partially Attenuates Simvastatin-Induced Myotoxic Responses in C2C12 Myotubes Through Metabolic Adaptation.FASEB J202642361123PubTator, text miningPubMed
Regulatory mechanism of heme-regulated inhibitor through autophosphorylation-driven activation and heme-induced deactivation.J Biochem202642350899PubTator, text miningPubMed
Mitochondrial integrated stress response activation creates a therapeutic vulnerability to MCL-1 inhibition in acute myeloid leukemia.Cell Death Dis202642350371PubTator, text miningPubMed
Understanding the OMA1-DELE1-HRI Axis and PINK1-parkin-mediated Mitophagy in Parkinson's Disease.CNS Neurol Disord Drug Targets202642261169PubTator, text miningPubMed
Iron: Regulation, redox homeostasis, and ferroptosis in cancer.Ferroptosis Oxid Stress202642099806PubTator, text miningPubMed
The integrated stress response in cancer: mechanisms of tumor adaptation and therapeutic targeting.Biochem Soc Trans202642043015PubTator, text miningPubMed

1 to 10 of 1,395

See all 1,395 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/27102

GET https://conductscience.org/api/genes/v1/27102/patents?page=2