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Gene · 27122

DKK3: dickkopf Wnt signaling pathway inhibitor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DKK3: dickkopf Wnt signaling pathway inhibitor 3. Genes, record 27122. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27122

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Gene

Symbol
DKK3
HGNC
Name
dickkopf Wnt signaling pathway inhibitor 3
HGNC
NCBI Gene ID
27122
NCBI Gene
HGNC ID
HGNC:2893
HGNC
Ensembl
ENSG00000050165
NCBI Gene
Aliases
CRRL, REIC, RIG
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UBP4Dickkopf-related protein 33500Ensembl, GeneID, HGNC

Source UniProt

Patents106

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026508054 A2026-03-1020Q9UBP4Espacenet
JP 2026000906 A2026-01-0692Q9UBP4Espacenet
EP 4650780 A22025-11-194983Q9UBP4Espacenet
EP 4640849 A22025-10-29692Q9UBP4Espacenet
EP 4641201 A22025-10-294565Q9UBP4Espacenet
EP 4641203 A22025-10-29159Q9UBP4Espacenet
JP 2025147176 A2025-10-064255Q9UBP4Espacenet
JP 2025147176 A2025-10-064256Q9UBP4Espacenet
JP 2025529142 A2025-09-046183Q9UBP4Espacenet
EP 4608873 A12025-09-0320Q9UBP4Espacenet

1 to 10 of 106

See all 106 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,466

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDKK3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
P30CA006973Regional Oncology Research Center62025
P30CA008748Cancer Center Support Grant62025
P30CA010815Consolidated Basic Cancer Research Program52025
P30CA046934University of Colorado Cancer Center Support Grant52025
P30CA062203Cancer Center Support Grant52025
P20GM103446Delaware INBRE42025
R01AI052014HIV-1 Preintegration Trafficking and Nuclear Localization42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025

1 to 10 of 1,466Source NIH's project files

See all 1,466 nih grants

Papers2,692

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Diagnostic and interventional radiology interest groups: comparison of members, activities, and funding.Diagn Interv Radiol202642734035PubTator, text miningPubMed
A dual-action humanized DKK-1 antibody that activates the Wnt/β-catenin signaling pathway and inhibits the RANKL signaling pathway for osteoporosis therapy.Front Immunol202642723851PubTator, text miningPubMed
Predictive Value of Urine Tubular Biomarkers on Kidney Outcomes: Observations from EMPA-KIDNEY.Clin J Am Soc Nephrol202642690923PubTator, text miningPubMed
When inflammation is not the driver: Pauci-immune synovitis and the stromal basis of refractory arthritis.EULAR Rheumatol Open202642662104PubTator, text miningPubMed
Identification of Progressive Islet Biomarkers for Type 2 Diabetes by Integrated Transcriptomics and Mendelian Randomization: Alterations Spanning the Normal Glucose Tolerance-Impaired Glucose Tolerance-Type 2 Diabetes Continuum.
Biomedicines202642652231PubTator, text miningPubMed
Dkk3-Cyp11b2/aldosterone signaling couples ion-homeostatic failure to mitochondrial apoptosis in cochlear aging.Cell Signal202642636949PubTator, text miningPubMed
Synthetically engineered probiotic suppresses colorectal cancer via inhibition of Wnt/β-catenin signaling.Cell Rep Med202642612617PubTator, text miningPubMed
Urinary Dickkopf-3 reflects renal and vascular damage in diabetic kidney disease: A cross-sectional study.Clin Nephrol202642572871PubTator, text miningPubMed
Urinary Dickkopf-3 as a biomarker for kidney-function decline: a systematic review and meta-analysis.Nephrol Dial Transplant202642566260PubTator, text miningPubMed
CKD screening: urinary albumin or uDKK3 or both?Nephrol Dial Transplant202642554977PubTator, text miningPubMed

1 to 10 of 2,692

See all 2,692 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/27122

GET https://conductscience.org/api/genes/v1/27122/patents?page=2