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Gene · 27165

GLS2: glutaminase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GLS2: glutaminase 2. Genes, record 27165. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27165

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Gene

Symbol
GLS2
HGNC
Name
glutaminase 2
HGNC
NCBI Gene ID
27165
NCBI Gene
HGNC ID
HGNC:29570
HGNC
Ensembl
ENSG00000135423
NCBI Gene
Aliases
GA, GLS, LGA, hLGA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UI32Glutaminase liver isoform, mitochondrial6024Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447844Q9UI32Espacenet
EP 4640849 A22025-10-29632Q9UI32Espacenet
EP 4641201 A22025-10-294252Q9UI32Espacenet
EP 4641202 A22025-10-294857Q9UI32Espacenet
JP 2025519096 A2025-06-24632Q9UI32Espacenet
JP 2025517969 A2025-06-124252Q9UI32Espacenet
KR 1020250017231 A2025-02-044857Q9UI32Espacenet
US 11446398 B22022-09-2035175Q9UI32Espacenet
JP 2022524081 A2022-04-27138146Q9UI32Espacenet
US 11078247 B22021-08-034506Q9UI32Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,287

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGLS2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30CA010815Consolidated Basic Cancer Research Program92025
P30CA016672Cancer Center Support Grant92025
R01CA102184Functional Analysis of p53 Polymorphic Variants82025
R01CA051497Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis72025
P30CA016520Abramson Cancer Center Support Grant62025
ZIAAI001079Mechanisms of Staphylococcus aureus virulence62025
R01AI099394Mechanistic Studies Of The Staphylococcus aureus LukAB Cytotoxin52025
R01GM100482Center for Critical Assessment of Structure Prediction (CASP)52025
UL1TR001863Yale Clinical and Translational Science Award52025

1 to 10 of 1,287Source NIH's project files

See all 1,287 nih grants

Papers2,122

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Structure, Biosynthesis, and Function of β-1,6-Glucan in the Fungal Cell Wall.Biomolecules202642793065PubTator, text miningPubMed
High-Throughput Characterization of Human Fibroblast Responses to a Panel of Staphylococcus aureus Antigen Proteins Using Olink Proteomics.Open Forum Infect Dis202642751267PubTator, text miningPubMed
miR-15a-5p Regulates Ferroptosis in Glioblastoma by Targeting GLS2.CNS Neurosci Ther202642669141PubTator, text miningPubMed
Resveratrol Alleviates Chronic Intermittent Hypoxia-Induced Lung Injury by Inhibiting Ferroptosis via SIRT1-Dependent Modulation of the EGR1/GLS2 Axis.Antioxid Redox Signal202642581022PubTator, text miningPubMed
LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer through glutaminolysis reprogramming.Cell Death Dis202642476970PubTator, text miningPubMed
Oxidative Stress Induced Senescent Macrophage-Driven Squamous Cell Carcinoma Invasion via Glutamine Metabolic Reprogramming.Aging Cell202642333921PubTator, text miningPubMed
B cells just got a workout.Cell202642208497PubTator, text miningPubMed
S-PrediXcan predicted gene expression in human placenta is associated with childhood-onset asthma risk.Sci Rep202642129325PubTator, text miningPubMed
Leveraging mitochondrial dynamics-related risk signatures to predict the prognosis and tumor microenvironment of lung adenocarcinoma.Discov Oncol202642104168PubTator, text miningPubMed
B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism.Cell202641999743PubTator, text miningPubMed

1 to 10 of 2,122

See all 2,122 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/27165

GET https://conductscience.org/api/genes/v1/27165/patents?page=2