Gene · 27183
VPS4A: vacuolar protein sorting 4 homolog A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. VPS4A: vacuolar protein sorting 4 homolog A. Genes, record 27183. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27183
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UN37 | Vacuolar protein sorting-associated protein 4A | 437 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents14
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 69498 | Q9UN37 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1524 | Q9UN37 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1138 | Q9UN37 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1138 | Q9UN37 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1524 | Q9UN37 | Espacenet |
| JP 2023530234 A | 2023-07-14 | 47 | Q9UN37 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 96202 | Q9UN37 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 199173 | Q9UN37 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 12515 | Q9UN37 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 249933 | Q9UN37 | Espacenet |
1 to 10 of 14
See all 14 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,284
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | VPS4A papers | Newest fiscal year |
|---|---|---|---|
| R01GM112080 | ESCRT and MIT Complexes in Cytokinesis | 14 | 2025 |
| R37AI051174 | Biochemistry of HIV-1 Budding | 13 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 6 | 2025 |
| R37AI112442 | Biochemical, Biophysical, and Structural Mechanisms of HIV-1 Budding and Release | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30CA042014 | Cancer Center Support Grant | 5 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 5 | 2025 |
| R01GM058202 | Ubiquitin-dependent sorting in endosomes and the TGN | 5 | 2025 |
| T32AI055434 | Training Program in Microbial Pathogenesis | 5 | 2025 |
| R01AI125244 | Neurotropic herpesvirus envelopment and microtubule-mediated transport | 4 | 2025 |
1 to 10 of 1,284Source NIH's project files
See all 1,284 nih grantsPapers1,887
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Large eukaryotic DNA viruses encode ESCRT machinery for membrane remodelling. | Nat Microbiol | 2026 | 42649410 | PubTator, text mining | PubMed |
| The proteasome promotes cytokinetic abscission by relieving an Aurora B-dependent inhibition of ESCRT-III dynamics. | Curr Biol | 2026 | 42636804 | PubTator, text mining | PubMed |
| Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress. | iScience | 2026 | 42630748 | PubTator, text mining | PubMed |
| Assembly and priming of the VPS4B AAA+ ATPase of the human ESCRT system. | Res Sq | 2026 | 42620047 | PubTator, text mining | PubMed |
| Asymmetry and Allostery: Insights into the Mechanism of Directional Peptide Translocation in AAA+ Unfoldases. | bioRxiv | 2026 | 42619752 | PubTator, text mining | PubMed |
| Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation. | Circ Res | 2026 | 42594169 | PubTator, text mining | PubMed |
| VPS4 and CHMP7 release centromeres from the nuclear envelope for post-mitotic positioning in daughter nuclei. | bioRxiv | 2026 | 42523392 | PubTator, text mining | PubMed |
| A novel VPS4A variant drives lipotoxicity underlying CIMDAG syndrome. | J Clin Lipidol | 2026 | 42498620 | PubTator, text mining | PubMed |
| Phosphatidylinositol diphosphate binding by ESCRT-III filaments. | Proc Natl Acad Sci U S A | 2026 | 42378278 | PubTator, text mining | PubMed |
| Extracellular vesicle cargo dynamics in the bone marrow microenvironment: from hematopoietic homeostasis to malignant transformation. | Extracell Vesicle | 2026 | 42344609 | PubTator, text mining | PubMed |
1 to 10 of 1,887
See all 1,887 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/27183
GET https://conductscience.org/api/genes/v1/27183/patents