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Gene · 27183

VPS4A: vacuolar protein sorting 4 homolog A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. VPS4A: vacuolar protein sorting 4 homolog A. Genes, record 27183. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27183

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Gene

Symbol
VPS4A
HGNC
Name
vacuolar protein sorting 4 homolog A
HGNC
NCBI Gene ID
27183
NCBI Gene
HGNC ID
HGNC:13488
HGNC
Ensembl
ENSG00000132612
NCBI Gene
Aliases
CIMDAG, FLJ22197, SKD1, SKD1A, SKD2, VPS4, VPS4-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UN37Vacuolar protein sorting-associated protein 4A4373Ensembl, GeneID, HGNC

Source UniProt

Patents14

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469498Q9UN37Espacenet
EP 4650780 A22025-11-191524Q9UN37Espacenet
EP 4641201 A22025-10-291138Q9UN37Espacenet
JP 2025517969 A2025-06-121138Q9UN37Espacenet
JP 2025517970 A2025-06-121524Q9UN37Espacenet
JP 2023530234 A2023-07-1447Q9UN37Espacenet
US 11446398 B22022-09-2096202Q9UN37Espacenet
JP 2022524081 A2022-04-27199173Q9UN37Espacenet
US 11078247 B22021-08-0312515Q9UN37Espacenet
JP 2019054813 A2019-04-11249933Q9UN37Espacenet

1 to 10 of 14

See all 14 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,284

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleVPS4A papersNewest fiscal year
R01GM112080ESCRT and MIT Complexes in Cytokinesis142025
R37AI051174Biochemistry of HIV-1 Budding132025
P30CA013330Cancer Center Support Grant62025
R37AI112442Biochemical, Biophysical, and Structural Mechanisms of HIV-1 Budding and Release62025
P30CA016672Cancer Center Support Grant52025
P30CA042014Cancer Center Support Grant52025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology52025
R01GM058202Ubiquitin-dependent sorting in endosomes and the TGN52025
T32AI055434Training Program in Microbial Pathogenesis52025
R01AI125244Neurotropic herpesvirus envelopment and microtubule-mediated transport42025

1 to 10 of 1,284Source NIH's project files

See all 1,284 nih grants

Papers1,887

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Large eukaryotic DNA viruses encode ESCRT machinery for membrane remodelling.Nat Microbiol202642649410PubTator, text miningPubMed
The proteasome promotes cytokinetic abscission by relieving an Aurora B-dependent inhibition of ESCRT-III dynamics.Curr Biol202642636804PubTator, text miningPubMed
Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress.iScience202642630748PubTator, text miningPubMed
Assembly and priming of the VPS4B AAA+ ATPase of the human ESCRT system.Res Sq202642620047PubTator, text miningPubMed
Asymmetry and Allostery: Insights into the Mechanism of Directional Peptide Translocation in AAA+ Unfoldases.bioRxiv202642619752PubTator, text miningPubMed
Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circ Res202642594169PubTator, text miningPubMed
VPS4 and CHMP7 release centromeres from the nuclear envelope for post-mitotic positioning in daughter nuclei.bioRxiv202642523392PubTator, text miningPubMed
A novel VPS4A variant drives lipotoxicity underlying CIMDAG syndrome.J Clin Lipidol202642498620PubTator, text miningPubMed
Phosphatidylinositol diphosphate binding by ESCRT-III filaments.Proc Natl Acad Sci U S A202642378278PubTator, text miningPubMed
Extracellular vesicle cargo dynamics in the bone marrow microenvironment: from hematopoietic homeostasis to malignant transformation.Extracell Vesicle202642344609PubTator, text miningPubMed

1 to 10 of 1,887

See all 1,887 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/27183

GET https://conductscience.org/api/genes/v1/27183/patents